Abstract: A method for encapsulating active ingredients in liposomes having an active ingredient solution encapsulated with a bilayer composed of two monomolecular layers of a first and a second amphiphilic compound, wherein the method comprises: (a) providing the active ingredient solution; (b) providing an emulsion by emulsifying the active ingredient solution in a first liquid in the presence of the first amphiphilic compound; (c) providing a mixture with a liquid phase with the second amphiphilic compound; (d) contacting the first emulsion with the mixture to form a phase boundary; and (e) centrifuging the first emulsion and the mixture wherein, on passage of the phase boundary, the second amphiphilic compound enriched there is added onto the monomolecular inner layer of the pre-liposomes to form a monomolecular outer layer, in order to create the bilayer.
Type:
Grant
Filed:
April 29, 2019
Date of Patent:
March 25, 2025
Assignee:
ABNOBA GMBH
Inventors:
Gero Leneweit, Bárbara Santos De Miranda
Abstract: A hybrid scaffold is disclosed which is made of materials that define peripheral layers designed to interface with the tissues in the implant site and one or more intermediate layers. The materials are combined to give the scaffold mechanical properties suitable for withstanding the stresses of the implant site. The materials are fibroin for the peripheral layers and polyurethane combined with fibroin for each intermediate layer.
Type:
Grant
Filed:
August 9, 2021
Date of Patent:
March 25, 2025
Assignee:
DIALYBRID S.R.L.
Inventors:
Francesco Giovanni Greco, Stefania Adele Riboldi, Sebastiao Nicolau Dentinho Van Uden, Valentina Ilaria Maria Catto, Davide Meroni
Abstract: The present invention provides a composition, comprising ferrous amino acid chelate particles sintered from ferrous amino acid chelate, wherein the average particle size of the ferrous amino acid chelate particles ranges from 500 nm to 2600 nm, and the average molecular weight of the particles ranges from 1,500 Dalton to 600,000 Dalton. Besides, the present invention can be used for manufacturing a medicament for treating or ameliorating a pancreas-related disease, wherein the medicament comprises an effective amount of the composition and a pharmaceutically acceptable carrier.
Abstract: A type II crystalline topramezone sodium salt hydrate, a preparation method of the type II crystalline topramezone sodium salt hydrate and the use thereof in herbicidal compositions is provided. An X-ray powder diffraction pattern of the hydrate recorded by Cu-Ka radiation at 25° C. shows at least 3 of the following reflections at 2? values: 2?=9.63±0.2°??(1) 2?=11.00±0.2°??(2) 2?=11.97±0.2°??(3) 2?=13.13±0.2°??(4) 2?=14.36±0.2°??(5) 2?=15.37±0.2°??(6) 2?=17.24±0.2°??(7) 2?=18.01±0.2°??(8) 2?=19.12±0.2°??(9) 2?=19.65±0.2°??(10) 2?=22.03±0.2°??(11) 2?=23.20±0.2°??(12) 2?=25.29±0.2°??(13) 2?=27.29±0.2°??(14) 2?=27.93±0.2°??(15) 2?=28.90±0.2°??(16).
Abstract: The present disclosure relates to a novel spherical agglomeration method for proteins, and protein particles made by the spherical agglomeration method. By using continuous oscillatory baffled crystallizer, the method of the present disclosure is capable of maintain the biologically activities and providing protein particles with an average particle size between 1-500 ?m.
Type:
Grant
Filed:
October 2, 2019
Date of Patent:
October 8, 2024
Assignee:
Purdue Research Foundation
Inventors:
Zoltan K. Nagy, Joseph A. Oliva, Kanjakha Pal
Abstract: A composition of psilocin that is stable including at least one agent or chemical modification that provides enhanced stability. A method making stable psilocin, by providing a formulation of psilocin including at least one agent or chemical modification that provides enhanced stability. A method of treatment of a disease or condition, by administering a composition of psilocin that is stable to an individual and treating the disease or condition.
Type:
Grant
Filed:
May 31, 2023
Date of Patent:
September 24, 2024
Assignee:
Mind Medicine, Inc.
Inventors:
Robert Barrow, Peter Mack, Stephen Schneider, Jon Schroeder, Gerald S. Jones