Patents Examined by Paul Holland
  • Patent number: 9877995
    Abstract: Fractions of whey permeate, preferably made of sweet whey permeate and more preferably of hydrolyzed or partially hydrolyzed sweet whey permeate are provided, particularly for use in the production of pharmaceutical compositions, or of food, for the treatment, prophylaxis, or alleviation of glucose intolerance and insulin resistance, and thus of symptoms of the metabolic syndrome, type 2 diabetes, and complications in humans.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: January 30, 2018
    Inventor: Jobst Krauskopf
  • Patent number: 9809781
    Abstract: Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described. The products of said methods are also described.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: November 7, 2017
    Assignee: The University of Toledo
    Inventors: Balakrishna Maddi, Sridhar Viamajala, Sasidhar Varanasi
  • Patent number: 9809834
    Abstract: The invention relates to processes of producing sugars and/or fermentation products from pretreated cellulosic material comprising the steps of: preconditioning pretreated cellulosic material; hydrolyzing using a cellulolytic enzyme preparation; and fermenting sugars with a microorganism; wherein a solid-liquid separation step, resulting in a solid fraction and a liquid fraction, is carried out: after preconditioning, but before hydrolysis; or after hydrolysis, but before fermentation; wherein phenol oxidizing enzyme and hemicellulase are present or added during preconditioning; after preconditioning, but before hydrolysis; or during hydrolysis.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: November 7, 2017
    Assignee: Novozymes A/S
    Inventors: Xin Li, Mads Torry Smith, Brandon Emme, Lorraine Putnam
  • Patent number: 9790521
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: October 17, 2017
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
  • Patent number: 9790520
    Abstract: A system and method for controlling bacteria, especially lactic and acetic acid bacteria in the production of ethanol using an organic oxidizing compound in combination with an inorganic oxidizer is provided. Particularly, a mixture of one or more peroxy acids and one or more peroxide compounds is introduced into a fermentation mash so as to inhibit or reduce levels of bacteria that compete with yeast for the fermentation sugars. The peroxy acid and peroxide compounds largely are consumed during the fermentation process and are generally not present in the fermentation by-products, especially recovered distiller's grains.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: October 17, 2017
    Assignee: DeLaval Holding AB
    Inventors: Reed Semenza, Michael Welker
  • Patent number: 9783834
    Abstract: The present invention relates to a process for producing a dicarboxylic acid, comprising fermenting a recombinant fungal cell in a suitable fermentation medium, in the presence of high carbon dioxide concentrations.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: October 10, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Mickel Leonardus August Jansen, Rene Verwaal
  • Patent number: 9777341
    Abstract: Described are methods for pretreating lignocellulosic biomass that comprise passing a hot aqueous biomass slurry through a heat exchange passage from an inlet to an outlet and locally regulating pressure in the passage by feed of a pressurized liquid medium to one or more intermediate locations of the passage. Also described are methods for producing ethanol from the pretreated biomass.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: October 3, 2017
    Assignees: Purdue Research Foundation, Bowen Engineering Corporation
    Inventors: Michael R. Ladisch, Brian Stater, Bradley Spindler
  • Patent number: 9771603
    Abstract: A methods for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The methods comprises increasing production of one or more products derived from acetolactate. Further provided is a method for increasing the production of 2,3-butandiol by microbial fermentation of gaseous substrates, the method comprising providing a compound which inhibits one or more enzymes which convert acetolactate to branched chain amino acids to the fermentation. The present invention further provides methods for increasing the production of 2,3-butandiol relative to other fermentation products such as ethanol and acetic acid.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: September 26, 2017
    Inventors: Kathleen Frances Smart, Alexander Paul Mueller, Michael James Harry Mawdsley, Christophe Daniel Mihalcea
  • Patent number: 9758798
    Abstract: Embodiments provided here relate to second generation processes for the production of alcohols or solvents, wherein the lignocellulosic or cellulosic biomass undergoes a pre-treatment before being converted into ethanol after an enzymatic hydrolysis and fermentation. The glucidic polymers of the pre-treated plant material are hydrolysed by cellulases. The alcoholigenic microorganisms used for the ethanolic fermentation principally use hexoses, for example, glucose and mannose. The alcohols of the liquor, with or without separation of the suspended material are extracted by distillation. The stillage, containing pentoses which have not been used, are fermented into an ex-pentose ethanolic liquor and at least a portion of the liquor is recycled upstream of the enzymatic hydrolysis.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: September 12, 2017
    Inventors: Marcel Ropars, Caroline Aymard, Rejane Dastillung, Sandra Menir
  • Patent number: 9745565
    Abstract: Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: August 29, 2017
    Assignee: NEPETX, LLC
    Inventor: David Schriemer
  • Patent number: 9745601
    Abstract: Methods and systems for producing a biofuel using genetically modified sulfur-oxidizing and iron-reducing bacteria (SOIRB) are disclosed. In some embodiments, the methods include the following: providing a SOIRB that have been genetically modified to include a particular metabolic pathway to enable them to generate a biofuel; feeding a first source of ferric iron to the SOIRB; feeding sulfur, water, and carbon dioxide to the SOIRB; producing at least the first particular biofuel, a first source of ferrous iron, sulfate, excess ferric iron, and an SOIRB biomass; electrochemically reducing the excess ferric iron to a second source of ferrous iron; providing an iron-oxidizing bacteria that have been genetically modified to include a particular metabolic pathway to enable them to generate a second biofuel; producing at least the second biofuel, a second source of ferric iron, and an IOB biomass; and feeding the second source of ferric iron to the SOIRB.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: August 29, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Scott Banta, Alan West, Timothy Kernan
  • Patent number: 9738910
    Abstract: At least one isolated microorganism and a fermentation method to convert hydrogen gas, carbon dioxide gas, and/or carbon monoxide gas to a lower alkyl alcohol and/or carboxylic acid and to produce at least 2% by volume of the lower alkyl alcohol or carboxylic acid in an aqueous-based medium.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: August 22, 2017
    Inventors: Richard Allen Kohn, Seon-Woo Kim
  • Patent number: 9732365
    Abstract: The invention relates to methods of making compounds useful for production of paclitaxel and analogs or derivatives thereof.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: August 15, 2017
    Assignee: Board of Trustees of Michigan State University
    Inventor: Kevin Walker
  • Patent number: 9733212
    Abstract: Pre-labeled protein standards useful in electrophoresis that have sharp, consistent separation characteristics that are substantially the same as those of their unlabeled counterparts are provided. The invention provides pre-labeled protein standard sets that include a plurality of labeled proteins that are labeled on a first amino acid, in which side reactions of the label with amino acids not targeted for labeling are reduced.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 15, 2017
    Inventors: Roumen Bogoev, Douglas Kang
  • Patent number: 9725743
    Abstract: A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4 -hydroxylase enzyme (C4H), the ratio Kcat(PAL)/Kcat(C4H) is at least 2:1.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: August 8, 2017
    Assignee: Evolva SA
    Inventors: Michael Katz, Jochen Forster, Helga David, Hans Peter Schmidt, Malin Sendelius, Sara Peterson Bjorn, Thomas Thomasen Durhuus
  • Patent number: 9719064
    Abstract: The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type—and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene- and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: August 1, 2017
    Inventors: Klaus Selber, Bernhard Weingaertner, Hermann Wehlmann, Winfried Rosen, Alfred Pühler, Patrick Schwientek, Jörn Kalinowski, Udo Wehmeier
  • Patent number: 9719114
    Abstract: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 1, 2017
    Assignee: TerraVia Holdings, Inc.
    Inventors: Scott Franklin, Aravind Somanchi, George Rudenko, Riyaz Bhat, Xinhua Zhao, Risha Bond, Walter Rakitsky, Alejandro Marangoni
  • Patent number: 9701972
    Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: July 11, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Klaassen, Gijsberdina Pieternella Van Suylekom, Rene Marcel De Jong
  • Patent number: 9689004
    Abstract: The invention relates to the fields of industrial microbiology and alcohol production. More specifically, the invention relates to improved production of butanol isomers by recombinant microorganisms containing an engineered butanol pathway and disrupted activity of the genes in pathways for the production of by-products during the fermentation when the microorganisms are grown in a fermentation medium containing acetate. In embodiments, recombinant microorganisms have an increased growth rate in a fermentation medium containing acetate as a C2 supplement.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 27, 2017
    Assignee: Butamax Advanced Biofuels LLC
    Inventor: Lori Ann Maggio-Hall
  • Patent number: 9682932
    Abstract: The present invention relates to a simple and economic method of extracting a crystalline Carotenoid compound, such as Beta-carotene, Lycopene, with a purity of at least 99%. The present invention further describes a process to prepare such a highly pure crystalline Carotenoid compound from microbial biomass, using an Anti-purity compound removal process followed by a mono-solvent extraction method. Further the process describes value addition of the co-products recovered during the extraction process thus resulting in a highly economical industrial method for the production of such high purity crystalline Carotenoids compound.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: June 20, 2017
    Inventors: Suresh Joseph, Arnaud Anandane