Abstract: There are described compounds of formula I, ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.7, which may be the same or different, each represent hydrogen, hydroxy, alkyl Cl to 6, alkoxy C1 to 6, amino, acyl C2 to 6, acylamino C2 to 6, alkenyl C2 to 6, halogen, or alkoxy C1 to 6 substituted by phenyl,X is a hydrocarbon chain of 1 to 10 carbon atoms optionally substituted by a hydroxy group,A is --Q--COOH,Q is absent or represents a straight or branched alkylene, alkenylene or alkynylene group of up to and including 6 carbon atoms,R.sub.8 and R.sub.9, which may be the same or different, each represent hydrogen or alkyl C1 to 6 or together form a single bond,D, Y and Z, which may be th same or different, each represent sulphur, oxygen or --NR.sub.10 --, andR.sub.10 is hydrogen or alkyl C1-C6,provided that(i) when D, Z and Y are all oxygen, R.sub.8 and R.sub.9 do not together form a single bond,(ii) when D is oxygen, R.sub.8 and R.sub.9 together form a single bond, X is (CH.sub.2).sub.

Abstract: A process for the preparation of indole and derivatives thereof wherein an aniline is reacted with a 1,2-glycol in the vapor phase, the liquid phase or a mixed vapor-liquid phase. A salt of a metal of group IIa of the periodic table, a salt of iron, a salt of cobalt and/or a salt of nickel are used as the catalyst for this reaction. The present invention makes it possible to prepare indole and derivatives thereof in a single step by using inexpensive compounds as the starting materials.

Abstract: 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.

Abstract: 7-(.alpha.,.alpha.-disubstituted-acetamido)-3-substituted-3-cephem-4-carbox ylic acids having antibacterial properties and the following formula are disclosed: ##STR1## wherein R.sup.1 is hydrogen, halogen, hydroxy, nitro, lower alkoxy or acylamino, R.sup.2 is hydrogen or acyl andR.sup.3 is lower alkanoyloxy, carbamoyloxy which may have lower alkyl, aryl or protective group for amino or a heterocyclicthio which may have lower alkyl.

Abstract: 5-Fluorocytosine hydrofluoride of high purity is prepared by fluorinating cytosine with fluorine gas in the presence of hydrogen fluoride, followed by treatment of the resultant fluorinated product in the reaction mixture at a temperature higher than the fluorination temperature.

Abstract: Disclosed are isomeric polyisobutenyl butyrolactones and lactams thereof useful as dispersants in lubricant oils and having the formulas: ##STR1## wherein R is a hydrocarbyl group having from 12 to 300 carbon atoms; X is O or >N--R', where R' is an alkyl or alkylamino group having from 1 to 20 carbon atoms and from 0 to 10 nitrogen atoms. The butyrolactones are made by mild reduction of the corresponding cyclic anhydrides and the lactams are prepared by reacting the intermediate butyrolactones with at least a molar equivalent of a primary amine, optionally, in the presence of a base or an acid.

Abstract: A process is disclosed for the manufacture of (7R,8R)-7-amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl) -thio]-methyl]-3-cephem-4-carboxylic acid by reacting (7R, 8R)-7-amino-cephalosporanic acid with 2,5-dihydro-6-hydroxy-3-mercapto-2-methyl-5-oxo-as-triazine in the presence of boron trifluoride or a complex compound thereof in a polar organic solvent and is characterized by precipitating the reaction product which is in aqueous phase in the form of the free acid by adding a base up to a pH-value of about 1.4-2.0, whereupon the desired pure acid can be separated.

Abstract: Novel 8-quinolinyl carbamates are disclosed possessing anti-bacterial and anti-fungal activity. The compounds show significant activity against gram-negative organisms making them useful in the treatment of urinary tract infections.

Abstract: Cationic dyes of the general formula ##STR1## where A and A' may be identical or different and are each a monovalent radical of a dye from the series comprising the azo or quinophthalone dyes, or A and A' independently of one another are each one of the radicals of the formulae ##STR2## R is C.sub.1 -C.sub.6 -alkyl, benzyl or aryl, R.sup.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl or aryl, D' and D" are respectively a monovalent and a divalent radical of a dye from the series comprising the triphenylmethane or xanthene dyes, n is an integer .gtoreq.1 and m is an integer .gtoreq.1, the sum (n+m) being .ltoreq.10 on average, are soluble in dilute acids, and, when they are used for wet-end dyeing of paper, give bleeding-fast, bleachable dyeings and a colorless effluent.

Abstract: Water or acidified water can be used to extract N-methylpyrrolidone from a mixture containing phenol and N-methylpyrrolidone. In one embodiment of this invention water or acidified water can be used to extract N-methylpyrrolidone from the kettle bottoms of the N-methylpyrrolidone recovery column of a poly(phenylene sulfide) polymerization process.

Abstract: The water soluble derivatives of cephalexin, having general formula: ##STR1## wherein X represents an alkali metal or the organic nitrogen containing cation of a basic aminoacid, combine the typical antibiotic action of cephalexin with the water solubility and form essentially neutral, aqueous solutions. The process for the preparation of the above derivatives comprises a first step in which the methylol derivative of cephalexin is prepared and a second step in which the treatment with a suitable base is carried out.

Abstract: This invention relates to thiadiazolyl compounds useful as intermediates in the preparation of novel cephem compounds of high antimicrobial activity.

Abstract: This invention relates to compounds and methods of using said compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, alkenyl or alkoxycarbonylalkyl; Y is O or S; m is an integer of 1 to 3 and n is an integer of 0 to 1 which compounds are insect repellents.

Abstract: (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamid o]-3-(1-pyridiniummethyl) ceph-3-em-4-carboxylate in the form of a crystalline bishydrochloride.The bishydrochloride has a well defined crystalline structure and exhibits good stability in storage. The bishydrochloride exhibits excellent antibiotic activity, particularly against organisms which are normally difficult to combat with .beta.-lactam antibiotics.

Abstract: There is described a new class of ketohydroxyimino derivatives of cephalosporins of the formula ##STR1## wherein: R is an alkyl radical having from 2 to 4 carbon atoms, a phenyl, or a 5-membered heterocyclic radical which may be substituted, containing nitrogen, oxygen and/or sulphur;R.sup.1 is an acetoxy, carbamoyloxy or S-heterocyclic group, which may be substituted, and the heterocyclic ring is a 5- or 6-membered ring containing one or more nitrogen atoms, alone or combined with sulphur;R.sup.2 is hydrogen, alkyl or acetyl.The present compounds have an interesting broad-spectrum antibacterial activity.

Abstract: Compounds of the formula: ##STR1## wherein X is halo; m and n are 0 or 1; R.sup.1 and R.sup.3 are hydrogen, alkyl or are joined to form a carbocyclic ring; R.sup.2 and R.sup.4 are hydrogen or alkyl;R.sup.5 and R.sup.6 are hydrogen, alkyl or alkoxyalkyl; R.sup.7 is hydrogen, halo, nitro, alkoxy or alkyl; and Y is oxygen or NR.sup.8 wherein R.sup.8 is hydrogen or alkyl, have herbicidal and growth-regulating activity, particularly against grassy weeds.

Abstract: N-[Heterocyclicaminocarbonyl]-1H-indene and tetrahydronaphthalene sulfonamides, such as 2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1H-indene-4-sul fonamide, are useful for the regulation of plant growth and as preemergent and postemergent herbicides.

Abstract: The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.

Abstract: The invention relates to derivatives of the family of cephalosporins, to a process for preparation thereof and to the therapeutic application thereof. The compounds of the invention correspond to formula: ##STR1## in which: ##STR2## is an acid, an alkaline or alkaline-earth salt, an amine salt or an ester;R.sub.3 is furyl or thienyl.

Abstract: A compound of the formula: ##STR1## in which R.sup.1 is thiadiazolyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is hydrogen, halogen or lower alkenyl, andR.sup.4 is carboxy or a protected carboxy group, and pharmaceutically acceptable salts thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.