Abstract: Systems and methods are provided for improving overall vision in patients suffering from a loss of vision in a portion of the retina (e.g., loss of central vision) by providing symmetric or asymmetric optic with aspheric surface which redirects and/or focuses light incident on the eye at oblique angles onto a peripheral retinal location. The intraocular lens can include a redirection element (e.g., a prism, a diffractive element, or an optical component with a decentered GRIN profile) configured to direct incident light along a deflected optical axis and to focus an image at a location on the peripheral retina. Optical properties of the intraocular lens can be configured to improve or reduce peripheral errors at the location on the peripheral retina. One or more surfaces of the intraocular lens can be a toric surface, a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface.

Abstract: Generally, an intraocular implant and methods for treating an ocular condition. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: A liquid crystal optical device is provided, including a layered structure including at least two support substrates. An external hole patterned control electrode is provided on one of the substrates and has an aperture. An internal hole patterned control electrode is provided on one of the substrates within the aperture, the internal and outer control electrodes being separated by a gap, which forms part of the aperture. A weakly conductive material is provided on one of the substrates over the aperture. A planar transparent electrode is provided on another one of the substrates. An alignment surface is provided on the substrates over the electrodes. A layer of liquid crystal material is contained by the substrates and in contact with the alignment surface of the substrates. A floating transparent electrode is provided on a side of one of the substrates opposite the outer and the internal hole patterned electrode.

Abstract: Provided is a drug-eluting coronary stent. In the drug-eluting coronary stent according to the present invention, electrospinning is used, thereby making it possible to precisely control a total content of an everolimus-based drug bound thereto and form a uniform layer in spite of not using a polymer causing late thrombosis, or the like.

Abstract: A mechanism for adjusting the chordae connecting the leaflets of a mitral valve to the papillary muscles in order to restore normal functioning of the mitral valve. The devices or mechanisms can correct problems associated with both prolapsed leaflets and restricted leaflets to allow the leaflets to properly coapt, thereby preventing or minimizing regurgitation. In accordance with the invention, the mechanisms or devices used for adjusting the chordae can be delivered and implanted in a minimally invasive and/or percutaneous manner, such as via transapical methods, transfermoral methods, or trans-septal methods.

Abstract: This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.

Abstract: An implantable system includes cells that produce and release a therapeutic agent, or agents, to a host in need. The system can include cells capable of eluting therapeutic agents in response to changing physiological conditions within a host. The system may comprise naked cells, encapsulated cells, or a mixture of non-encapsulating and encapsulated cells. The system may also comprise cells, and/or cell groups, of different origins. The implantable device may be placed intra-vascular, within bone marrow, within soft tissue, in the peritoneal cavity, or intra-hepatic, etc. The system can be comprised of a stent, or like devices. Such stents and like devices may optionally include port(s), catheter(s), and containment envelope systems for holding the above cells.

Abstract: A movable ocular prosthetic apparatus and related systems and methods for moving an ocular prosthetic include a support member. An ocular prosthetic is mounted to the support member, wherein the ocular prosthetic is movable about the at least two axes of rotation. A control system controls a movement of the ocular prosthetic based on a sensed movement of a pupil of an eyeball of a human being.

Abstract: The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one dealloyed nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.

Abstract: An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. The device can have multiple flat sides that remain flat during expansion. A method of repairing tissue is also disclosed. Devices and methods for adjusting (e.g., removing, repositioning, resizing) deployed orthopedic expandable support devices are also disclosed. The expandable support devices can be engaged by an engagement device. The engagement device can longitudinally expand the expandable support device. The expandable support device can be longitudinally expanded until the expandable support device is substantially in a pre-deployed configuration. The expandable support device can be then be physically translated and/or rotated.

Abstract: Systems for mitral valve repair are disclosed where one or more mitral valve interventional devices may be advanced intravascularly into the heart of a patient and deployed upon or along the mitral valve to stabilize the valve leaflets. The interventional device may also facilitate the placement or anchoring of a prosthetic mitral valve implant. The interventional device may generally comprise a distal set of arms pivotably and/or rotating coupled to a proximal set of arms which are also pivotably and/or rotating coupled. The distal set of arms may be advanced past the catheter opening to a subannular position (e.g., below the mitral valve) and reconfigured from a low-profile delivery configuration to a deployed securement configuration. The proximal arm members may then be deployed such that the distal and proximal arm members may grip the leaflets between the two sets of arms to stabilize the leaflets.

Abstract: This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

Abstract: An intraocular assembly includes a peripheral side wall (12) that has a rim (16) sized to receive therein an intraocular device, and a posterior peripheral edge (20) that is sharp and extends out from a posteriorly-facing end face (22) of the side wall. An interior perimeter of the rim is a combination of continuous concave and convex shapes.

Abstract: An ophthalmic lens comprising a main lens part, a recessed part, an optical center, and an optical axis through the optical center. The main lens part has at least one boundary with the recessed part and has an optical power of between about ?20 to about +35 diopter. The recessed part is positioned at a distance of less than 2 mm from the optical center and includes a near part having a relative diopter of about +1.0 to about +5.0 with respect to the optical power of the main lens part. The boundary or boundaries of the recessed lens part with the main lens part form a blending part or blending parts, are shaped to refract light away from the optical axis, and have a curvature resulting in a loss of light, within a circle with a diameter of 4 mm around the optical center, of less than about 15%.

Abstract: Lenses, devices, apparatus, systems, methods of manufacturing and fabricating an ophthalmic lens device for correction of human vision. The ophthalmic lens device includes at least one diffractive waveplate coating with an optical axis orientation pattern designed to correct the vision of individual patients. The ophthalmic lens device including diffractive waveplate coating may also provide a portion of the required vision correction by means of refraction of light by curved surfaces of a dielectric material.

Abstract: Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.

Abstract: In one embodiment, a flexible strain sensor includes a flexible substrate having a top surface and a layer of piezoresistive amorphous carbon formed on the top surface of the substrate.

Abstract: The invention is about a permanent total artificial heart device that is developed for the patients who are at the end-stage heart failure and included in the heart transplantation program, and which is placed into the ventricles of the patient's heart completely or placed surgically into the space obtained when a piece of ventricle is removed. The device employs “direct drive technology,” technically using the advantages of brushless electric motors. Special-designed engines require quite little energy for the pulsatile blood flow produced by stopping and starting synchronously with the ECG signals. It is about a permanent total artificial heart device system that will offer high quality of life for many years to the patients as it protects the heart valves and heart conduction system, has wireless charging and longer battery life.

Abstract: A method of preventing capsular opacification and fibrosis utilizing an accommodative intraocular lens implant, which includes the steps of removing a cortex and nucleus of a natural lens containing a cataract from a lens capsule of an eye of a patient; applying a photosensitizer inside the lens capsule so that the photosensitizer permeates a portion of the lens capsule, the photosensitizer facilitating cross-linking of the tissue in the portion of the lens capsule; irradiating the portion of the lens capsule so as to activate cross-linkers in the tissue in the portion of the lens capsule, thereby damaging the remaining lens epithelial cells in the lens capsule with the irradiated light so as to prevent capsular opacification and fibrosis; and injecting a transparent polymer into the lens capsule of the eye in order to form an accommodative intraocular lens for replacing the cortex and nucleus of the natural lens.

Abstract: A prosthetic heart valve includes three bioprosthetic leaflets, each having an arcuate outer edge opposite a coapting edge and two tabs located on opposite sides of the coapting edge. The prosthetic heart valve also includes a self-expandable support frame defining three commissures spaced 120 degrees apart. Each commissure preferably includes two axially-extending attachment flanges with an axial slot therebetween. Each attachment flange includes a plurality of assembly holes through which sutures are passed to secure the leaflet tabs to the attachment flanges. The prosthetic heart valve also includes three outwardly flared U-shaped stabilizing members integrally formed with the leaflet support frame. The three stabilizing members having outer apices spaced 120 degrees apart and offset by 60 degrees from the three commissures. The stabilizing members are shaped to contact the surrounding aorta for stabilizing and anchoring the prosthetic heart valve in the implant position.