Patents Examined by Paul W Dickinson
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Patent number: 12156922Abstract: Complexes comprising a coordinated Cu(II) ion are described herein, which are capable of binding to an extracellular portion of Ctr1 such that the complex with the Cu(II) ion is transported through the Ctr1. The complexes may comprise a Cu(II) ion coordinated to a ligand and to a peptide, wherein the peptide is released upon contact of the complex with an extracellular portion of Ctr1, thereby forming a second complex comprising the ligand, the copper ion and the extracellular portion of Ctr1. Further described herein are uses and methods utilizing the complex, in imaging, in radiation therapy, and for determining a redox state of cells.Type: GrantFiled: May 7, 2020Date of Patent: December 3, 2024Assignee: Bar-Ilan UniversityInventors: Sharon Ruthstein, Yulia Shenberger
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Patent number: 12157791Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.Type: GrantFiled: February 10, 2021Date of Patent: December 3, 2024Assignee: The Regents of the University of CaliforniaInventors: Anthony M. Rush, Nathan Gianneschi, Carrie James
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Patent number: 12150996Abstract: The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, said polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.Type: GrantFiled: November 16, 2018Date of Patent: November 26, 2024Assignees: Centre National De La Recherche Scientifique, Universite Paris-SaclayInventors: Nicolas Tsapis, Julien Nicolas, Tanguy Boissenot, Alexandre Bordat
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Patent number: 12152182Abstract: Disclosed herein are semiconducting polymers of formula I and polymeric composite materials containing said polymer, where said polymer displays near-infrared afterglow luminescence. The polymers of formula I have the following structure: where n, m, o, p, A and R1 to R7 are as defined herein, and r is used to denote a random order to the repeating units.Type: GrantFiled: August 1, 2018Date of Patent: November 26, 2024Assignee: Nanyang Technological UniversityInventors: Kanyi Pu, Qingqing Miao
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Patent number: 12144874Abstract: The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.Type: GrantFiled: May 14, 2020Date of Patent: November 19, 2024Assignee: On Target Laboratories, Inc.Inventors: Sumith A. Kularatne, Pravin Gagare
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Patent number: 12144875Abstract: Provided are methods, imaging agents and kits for determination of the distribution and expression levels of an immune checkpoint ligand (such as PD-L1 or a PD-L1 like ligand) in an individual having a disease or condition. Anti-PD-L1 antibody agents are also provided.Type: GrantFiled: May 31, 2019Date of Patent: November 19, 2024Assignee: Tayu Huaxia Biotech Medical Group Co., Ltd.Inventors: Lieping Chen, Liqun Luo, Zhenguo Wen, Qianyong Liu
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Patent number: 12145875Abstract: Polyphosphate glass microspheres (PGMs) are prepared using a polyphosphate coacervate. PGMs can be loaded with various therapeutic agents and can be used for various medical and dental procedures and treatments.Type: GrantFiled: September 27, 2016Date of Patent: November 19, 2024Inventors: Mark Filiaggi, Arash Momeni
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Patent number: 12064492Abstract: The present invention refers to cells from a subpopulation of progenitors of endothelial cells loaded with gold nanoparticles sensitive to excitation with infrared radiation with consequent release of thermal energy, to a composition having a plurality of these cells and to their use in the diagnosis and treatment of solid tumours thanks to the selective localization of the composition in the tumour mass, which can be thus identified easily for diagnostic purposes by marking the cells with appropriate marking agents, or treated by stimulation with pulsed laser beam up to the complete cauterization of the tumour mass for a targeted and highly effective therapeutic action.Type: GrantFiled: May 3, 2017Date of Patent: August 20, 2024Assignee: Universita degli Studi di FirenzeInventors: Angela Zoppi, Mario Del Rosso, Anna Laurenzana, Gabriella Fibbi, Francesca Margheri, Anastasia Chilla', Giancarlo Margheri
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Patent number: 12042544Abstract: Provided are a stem cell-nano anticancer drug complex in which an anticancer drug based on carbon nanotubes (CNT) and gold (Au) nano particles is loaded on the surface of stem cells, which can overcome side effects of conventional stem cells and targeting limitations of nano anticancer drugs and whose anticancer effect is very excellent, the use thereof, and a method for preparing the same.Type: GrantFiled: April 19, 2018Date of Patent: July 23, 2024Assignee: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Dong Woo Khang, Yeon Kyung Lee, Sang-Woo Kim, Jun-Young Park
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Patent number: 12016931Abstract: The present invention provides nanoparticles comprising: (a) an amphiphilic polymer with a number average molecular weight (Mn) of 20,000 g/mol or less; and (b) a peptide that is covalently linked to the polymer, wherein the peptide comprises 8 to 50 amino acids, including an N-terminal linker sequence comprising at least one Arg amino acid residue and a sequence comprising an MHC binding sequence comprising a T cell receptor epitope. The present invention further comprises compositions comprising respective nanoparticles and a liquid or lyophilized carrier as well as nanoparticles and compositions of the invention for use in inducing tolerance to a therapeutic compound (protein, viral vector, lipid vesicle), an allergen or to an autoantigen or for treating an allergy, an autoimmune disease, an exogenous antigen (transplantation antigens, drugs) or a food intolerance.Type: GrantFiled: July 26, 2023Date of Patent: June 25, 2024Assignee: Topas Therapeutics GmbHInventors: Johannes Pohlner, Reinaldo Digigow, Barbara Metzler, Sabine Fleischer
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Patent number: 12005129Abstract: In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises, consists of, or consists essentially of an MRI-active or MRI-sensitive polymer or oligomer formed from (i) a non-alkoxylated and non-alkenoxylated citric acid, citrate, or ester/amide of citric acid, and optionally an alkoxylated or alkenoxylated citric acid, citrate, or ester/amide of citric acid, (ii) a polyol/polyamine such as a diol/diamine, (iii) a monomer comprising an MRI contrast agent, and (iv) an amino acid monomer. The polymer or oligomer may be photoluminescent and MRI-sensitive. In another aspect, imaging methods utilizing the compositions described herein are described. In another aspect, scaffolds, grafts, and films comprising, consisting of, or consisting essentially of the compositions described herein are described.Type: GrantFiled: October 6, 2017Date of Patent: June 11, 2024Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Jian Yang, Dingying Shan, Nanyin Zhang
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Patent number: 11992506Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.Type: GrantFiled: November 1, 2022Date of Patent: May 28, 2024Assignee: VERTEX PHARMACEUTICALS INCORPORATEDInventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
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Patent number: 11963605Abstract: The present disclosure relates to, inter alia, a green technology for crosslinking protein molecules for various uses, where the protein molecules can be contained in protein fibers such as, but not limited to, human hair, animal fibers, and mixtures thereof. In one aspect, the present disclosure relates to a crosslinking agent comprising an oxidized sugar having at least two aldehyde groups. In another aspect, the present disclosure relates to a method of crosslinking protein fibers. This method involves providing the aforementioned crosslinking agent and infiltrating a plurality of non-crosslinked protein fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked protein fibers to become crosslinked, thereby yielding a population of crosslinked protein fibers.Type: GrantFiled: May 28, 2021Date of Patent: April 23, 2024Assignee: CORNELL UNIVERSITYInventors: Anil N. Netravali, Yidong Zhong
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Patent number: 11957760Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.Type: GrantFiled: March 14, 2023Date of Patent: April 16, 2024Assignee: Elucida Oncology, Inc.Inventors: Kai Ma, Aranapakam M. Venkatesan, Feng Chen, Fei Wu, Melik Ziya Türker, Thomas Courtney Gardinier, II, Geno J. Germano, Jr., Gregory Paul Adams, Francis Y. F. Lee
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Patent number: 11950995Abstract: A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.Type: GrantFiled: March 31, 2023Date of Patent: April 9, 2024Assignee: ISLA Technologies, Inc.Inventors: Sara Joan Photiadis, Douglas Marc Photiadis, Thomas A. Kramer
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Patent number: 11945789Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model.Type: GrantFiled: March 18, 2019Date of Patent: April 2, 2024Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.Inventors: Juan R. Del Valle, Chih-Chi Andrew Hu
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Patent number: 11925692Abstract: The present invention pertains to the field of pre-functionalized nanoparticles (NPs). It relates more particularly to NPs pre-functionalized using a self-assembled monolayer (SAM) and also to NPs functionalized using biomolecules such that the NPs are stable in solution. These NPs may be used in numerous applications, especially as a diagnostic tool, for depleting a molecule of interest in a solution, and therapeutic tool.Type: GrantFiled: June 12, 2020Date of Patent: March 12, 2024Assignees: Ecole Normale Supérieure Paris-Saclay, Centre National de la Recherche ScientifiqueInventors: Claude Nogues, Malcolm Buckle, Stéphanie Vial
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Patent number: 11918657Abstract: Low-generation dendrimers containing a high density of surface hydroxyl groups, and methods of synthesis thereof are provided. In particular, oligo ethylene glycol (OEG)-like dendrimers with a high surface functional groups at relatively low generations (e.g. ˜120 hydroxyls in the third generation, with a size of just 1-2 nm) is described. Dendrimer formulations including one or more prophylactic, therapeutic, and/or diagnostic agents, and methods of use thereof are also described. The formulations are suitable for topical, enteral, and/or parenteral delivery for treating one or more diseases, conditions, and injuries in the eye, the brain and nervous system (CNS), particularly those associated with pathological activation of microglia and astrocytes.Type: GrantFiled: November 13, 2018Date of Patent: March 5, 2024Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Kannan Rangaramanujam, Rishi Sharma, Anjali Sharma, Sujatha Kannan, Zhi Zhang, Siva Pramodh Kambhampati
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Patent number: 11896599Abstract: Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.Type: GrantFiled: January 18, 2019Date of Patent: February 13, 2024Assignee: Supernus Pharmaceuticals, Inc.Inventors: Padmanabh P. Bhatt, Argaw Kidane, Kevin Edwards
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Patent number: 11896800Abstract: Disclosed herein are self-degradable microneedle devices for the controlled-release of an immunotherapeutic agent. Also disclosed are methods for treating a disease (for example, cancer) using a self-degradable microneedle patch for the sustained delivery of an immunotherapeutic agent (for example, a PD1 antibody).Type: GrantFiled: March 1, 2017Date of Patent: February 13, 2024Assignee: NORTH CAROLINA STATE UNIVERSITYInventors: Zhen Gu, Chao Wang, Yanqi Ye