Patents Examined by Paul W Dickinson
  • Patent number: 11596697
    Abstract: Conjugates comprising a drug, cell or biological molecule bound to a photoluminescent polymer nanoparticle, in particular a cross-linked polyfluorene nanoparticle, are described herein, as well as their methods of manufacture and their uses in biological imaging and sensing applications.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: March 7, 2023
    Assignee: Chromition Limited
    Inventors: Mark McCairn, Michael Turner, Benjamin Lidster
  • Patent number: 11590264
    Abstract: Methods of varying the stiffness of polymeric medical tubes.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: February 28, 2023
    Assignee: Hollister Incorporated
    Inventors: David J. Farrell, Padraig M. O'Flynn, John P. O'Mahony, Richard Meaney, John T. Clarke
  • Patent number: 11590235
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: February 28, 2023
    Assignee: Kodiak Sciences Inc.
    Inventors: Stephen A. Charles, Daniel Victor Perlroth, Li Song, Martin Linsell, Wayne To, Didier Benoit, James Aggen
  • Patent number: 11577092
    Abstract: A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose distribution. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose comprising a pulsed sequence of x-rays delivering from 0.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: February 14, 2023
    Inventors: Harold Walder, Frederic A. Bourke, Jr., Zakaryae Fathi, Wayne Beyer, Mark Oldham, Justus Adamson, Paul Yoon
  • Patent number: 11559585
    Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: January 24, 2023
    Assignee: The Regents of the University of California
    Inventors: Yuanpei Li, Xiangdong Xue, Yee Huang, Zhao Ma
  • Patent number: 11554093
    Abstract: A hair fixative composition comprising a film forming polymer that is prepared from monomers comprising (a) 10-30% by weight of one or more copolymerizable comonomers selected from the group consisting of N-alkyl (meth)acrylamide wherein the alkyl group thereof contains from 2 to 12 carbon atoms, wherein for at least one of said copolymerizable comonomers the alkyl group contains from 5 to 12 carbon atoms; (b) 14-21% by weight of copolymerizable comonomers comprising acrylic acid and optionally one or more acidic copolymerizable comonomers selected from the group consisting of methacrylic acid, crotonic acid, itaconic acid, maleic acid, fumaric acid, and the (C1-C4)alkyl half esters of maleic and fumaric acids; and (c) 40-76% by weight two or more copolymerizable comonomers selected from the group consisting of (C1-C12)alkyl(meth)acrylates, wherein at least one of said two or more copolymerizable comonomers is a (C1-C2)alkyl(meth)acrylate; said film forming polymer being optionally completely or partially neu
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: January 17, 2023
    Inventors: Jean-Pierre Leblanc, Michael Timothy Philbin
  • Patent number: 11530300
    Abstract: Disclosed is a method of crosslinking protein fibers, including wool fibers, by (i) providing a crosslinking agent including an oxidized sugar mixture having a plurality of different oxidized sugars of different molecular lengths and having at least two aldehyde groups (e.g., oxidized soy flour sugars); and (ii) infiltrating a plurality of non-crosslinked protein fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked protein fibers to become crosslinked. This method yields a population of crosslinked protein fibers, where the protein molecules of the non-crosslinked protein fibers include amine groups that react with the aldehyde groups of the oxidized sugars to achieve the crosslinking of the protein molecules to yield the crosslinked protein fibers.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: December 20, 2022
    Inventors: Anil N. Netravali, Namrata V. Patil
  • Patent number: 11517416
    Abstract: A bioartificial device, such as a bioartificial pancreas, for implantation in a patient's vascular system. The bioartificial pancreas includes a scaffold adapted to engage an interior wall of a blood vessel, a cellular complex support by the scaffold and extending longitudinally within the interior cavity of the scaffold so as to be exposed to the blood flow when the scaffold is engaged with the blood vessel, the cellular complex support comprising one or more pockets bordered by thin film; and cellular complex comprising pancreatic islets disposed in the one or more pockets, the thin film being adapted to permit oxygen and glucose to diffuse from flowing blood into the one or more pockets at a rate sufficient to support the viability of the islets. The invention also includes methods of making and using a bioartificial pancreas.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: December 6, 2022
    Assignee: Isla Technologies, Inc.
    Inventors: Sara Joan Photiadis, Douglas Marc Photiadis, Thomas A. Kramer
  • Patent number: 11505525
    Abstract: Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: November 22, 2022
    Assignees: Quanta BioDesign, Ltd., University of Washington
    Inventors: Paul D. Davis, D. Scott Wilbur
  • Patent number: 11504434
    Abstract: In one aspect, methods of targeted nanoparticles and cell delivery are described herein. In some embodiments methods described herein comprise coupling nanoparticles and cells to a carrier cell to form a nanoparticle-cell conjugate or cell-cell conjugate, disposing the nanoparticle-cell or cell-cell conjugate in a biological environment, and delivering the nanoparticles and cells to target cells or tissues located within the biological environment. The nanoparticles comprise a biodegradable photoluminescent polymer, and the nanoparticle-cell conjugate is formed using one or more click chemistry reaction products.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: November 22, 2022
    Assignee: The Penn State Research Foundation
    Inventors: Jian Yang, Cheng Dong, Zhiwei Xie
  • Patent number: 11497809
    Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: November 15, 2022
    Inventors: Xiaoyu Wu, Claudia Regina Gordijo, Azhar Z. Abbasi, Preethy Prasad, Mohammad Ali Amini
  • Patent number: 11491224
    Abstract: Provided herein are porphyrinato-lanthanide complexes useful as theranostic agents and methods of preparation and use thereof. The porphyrinato-lanthanide complexes are useful in the treatment and imaging of cancer.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: November 8, 2022
    Assignee: Hong Kong Baptist University
    Inventors: Ka Leung Wong, Wai Kwok Wong, Ho Fai Chau
  • Patent number: 11471542
    Abstract: Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin through equilibrium or enforced adsorption technique. Methods for dual delivery of SPIONs and curcumin to a target for diagnosis or therapy, for example, for SPION-based magnetic resonance imaging or for targeted delivery of curcumin to a cell or tissue. The technique can be extend to co-precipitation of mixed metal oxide involving Ni, Mn, Co and Cu oxide. The calcination temperature can be varied from 500-900° C. The nanocombination is functionalized with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility in vivo.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: October 18, 2022
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventors: B. Rabindran Jermy, Vijaya Ravinayagam
  • Patent number: 11391711
    Abstract: The present disclosure discloses a gold/quantum dot nanoprobe for detecting active ricin in a complex matrix and application thereof. The gold/quantum dot nanoprobe is a nanoprobe formed by utilizing gold nanoparticles and quantum dots, which are modified by single strand oligodeoxynucleotides (ssODN), to form double strand oligodeoxynucleotides in a base pairing hybridizing mode and assembling the gold nanoparticles and the quantum dots into a core-satellite structure. According to the present disclosure, the gold/quantum dot nanoprobe is used for detecting the active ricin, has a limit of detection of 7.46 ng/mL, is high in accuracy and good in reliability, and does not require large-scale equipment and complex operations. In order to further eliminate the false positive result, the present disclosure further provides a method for enriching ricin in a complex sample by utilizing magnetic beads.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: July 19, 2022
    Inventors: Bing Shao, Jiefang Sun, Jing Zhang
  • Patent number: 11351263
    Abstract: Provided herein are nanoplexes comprising a payload selected from a protein and/or a polynucleic acid; and a plurality of copolymers comprising a first copolymer that is poly(N,N?-bis(acryloyl)cystamine-poly(aminoalkyl)) (PBAP), a second copolymer that is poly(C2-3 akylene glycol)-PBAP-poly(C2-3 akylene glycol), and a third copolymer that is TG-poly(C2-3 akylene glycol)-PBAP-poly(C2-3 akylene glycol)-TG wherein TG at each occurrence is independently a targeting ligand, a cell penetrating peptide, an imaging agent or a capping group, provided that a plurality of TG groups is a targeting ligand; wherein the payload is non-covalently complexed to one or more of the copolymers, one or more of the first, second, and/or third copolymers comprises an endosomal escape group having a pKa of about 4.5 to about 6.5, and optionally one or more of the first, second, and/or third copolymers comprises a host and a guest non-covalent crosslinker.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: June 7, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shaoqin Gong, Yuyuan Wang, Krishanu Saha, Amr Ashraf Abdeen
  • Patent number: 11348702
    Abstract: An isotope production system, emanation generator, and process are disclosed for production of high-purity radioisotopes. In one implementation example, high-purity Pb-212 and/or Bi-212 isotopes are produced suitable for therapeutic applications. In one embodiment the process includes transporting gaseous radon-220 from a radium-224 bearing generator which provides gas-phase separation of the Rn-220 from the Ra-224 in the generator. Subsequent decay of the captured Rn-220 accumulates high-purity Pb-212 and/or Bi-212 isotopes suitable for direct therapeutic applications. Other high-purity product isotopes may also be prepared.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: May 31, 2022
    Assignee: Battelle Memorial Institute
    Inventor: Matthew J. O'Hara
  • Patent number: 11311512
    Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: April 26, 2022
    Assignee: Monash University
    Inventors: Chris Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Patent number: 11311400
    Abstract: The invention provides methods to prepare protein conjugates from proteins having at least two cysteines. In one embodiment, a protein with a disulfide linkage is reduced to provide two free cysteines for reaction with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form a Schiff base to an aminated payload molecule, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant. The linkage between the sulfur atoms in each case holds the protein or peptide in a constrained conformation, while also providing a convenient place for attaching a payload with good specificity and efficiency.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: April 26, 2022
    Assignee: Novartis AG
    Inventors: Qi-Ying Hu, Hidetomo Imase
  • Patent number: 11286352
    Abstract: A process for the preparation of beads including a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohol and optionally a metal compound, including the steps of: adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, adding the first liquid mixture to an aqueous solution of a biocompatible surfactant including polyvinylalcohol under sonication to obtain a second liquid mixture, a) maintaining the sonication of the second liquid mixture while cooling, b) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads including the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, c) separating the beads from the suspension and preparing a water suspension of the beads and d) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: March 29, 2022
    Inventors: Mangala Srinivas, Olga Koshkina, Carl Gustav Figdor, Ingrid Jolanda Monique De Vries
  • Patent number: 11266742
    Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: March 8, 2022
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus