Abstract: Texaphyrin/chemotherapeutic drug conjugates, optionally including a platinum(II) or platinum(IV) metal chelating site and/or complex, are useful for treating atheroma, tumors and other neoplastic tissue, neovascular-related diseases, as well as other conditions that are typically responsive to chemotherapy, radiation sensitization and photodynamic therapy.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
March 27, 2001
Inventors:
Jonathan L. Sessler, Darren Magda, Tarak Mody, Pavel Anzenbacher, Jr., Joan Carvalho
Abstract: There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.
Type:
Grant
Filed:
February 2, 1993
Date of Patent:
May 10, 1994
Assignee:
Merck & Co., Inc.
Inventors:
Michael H. Fisher, William R. Schoen, Matthew J. Wyvratt, Robert J. DeVita