Abstract: According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein: the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

Abstract: The present invention relates to a composition for preventing or treating hearing loss, containing an HMG-CoA reductase inhibitor and, more specifically, to a composition for preventing or treating diabetes-mediated hearing loss, containing, as an active ingredient(s), one or more types selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. A pharmaceutical composition containing an HMG-CoA reductase inhibitor, according to the present invention, inhibits auditory cell death caused by diabetes, and thus is very useful as an agent for preventing or treating diabetes-mediated sensorineural hearing loss.

Abstract: The present invention relates to a novel directly compressible matrix for the production of tablets which disintegrate rapidly in the presence of moisture, in particular in the mouth.

Abstract: In various embodiments, the present invention is directed to oral pharmaceutical compositions. For example, in some embodiments, the present invention is directed to taste-masked compositions. In some embodiments, the taste masked compositions comprise a highly water soluble drug such as amphetamine, e.g., in the form of a salt such as amphetamine sulfate. In various embodiments, the present invention is directed to taste-masked, orally disintegrating compositions.

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to a cosmetic composition containing an oil mixture in a total amount of from about 40 to about 99% by weight, in relation to the total amount of the cosmetic composition, without taking into consideration any propellant possibly provided, wherein the oil mixture of at least two selected esters, at least one linear polydimethylsiloxane with a viscosity of from about 1 to less than about 20 cSt, also PPG-14 butyl ether, wherein cyclic polydimethylsiloxanes are contained in a total amount, in relation to the total amount of the cosmetic composition, of from 0 to about 0.4% by weight, and wherein PPG-14 butyl ether and linear polydimethylsiloxanes are contained in selected ratios by weight to one another.

Abstract: A topical supplement composition. The topical supplement composition includes one or more vitamins, minerals, or other nutrients, in combination with one or more suitable transdermal carriers. The topical supplement composition delivers vitamins, minerals or other nutrients via transdermal application from an individual's skin to the individual's bloodstream.

Abstract: The present disclosure provides compositions comprising phosphate salts having low levels of aluminum, as well as other elemental impurities. In general, phosphate salts compositions disclosed herein are liquid compositions (e.g., admixtures, solutions) comprising in situ formed phosphate salts, a pharmaceutically acceptable carrier, and less than about 250 ?g/L of aluminum. Phosphate salts solutions disclosed herein are stable over time (e.g., the amount of total phosphorus and/or the ratio of phosphate salts and/or the level of aluminum does not substantially vary, and the compositions remain free of visible particulate matter). The compositions do not require storage at less than ambient (room) temperature, i.e., no refrigeration is needed. Also provided herein are methods and systems for preparing in situ phosphate salts compositions, and methods of using phosphate salt compositions to provide phosphorous to individuals in need thereof.

Abstract: The presently disclosed subject matter provides a coating composition which allows for the co-delivery of two or more bioactive agents with independent control of loading level and release profile for each bioactive agent, an implantable medical device coated with the coating composition, and methods for preparing the coating composition.

Abstract: The use of long-chain alkenones to impart desired characteristics in personal care compositions for topical applications is described. The preparation of mixtures long-chain alkenones and synthetic derivatives thereof is presented. Examples of compositions include abrasive soaps, with alkenones serving as natural exfoliating agents. Alkenones and their derivatives can serve as emollients, occlusive agents, encapsulating agents, stabilizing agents, binding agents, thickening agents, surfactants, and antimicrobials.

Abstract: Control or repellency of bed bugs is accomplished by bringing the bed bugs into contact with at least one of the compounds of the structure (I) Wherein R is selected from —OH, —OC(O)R4, —OR6, —(OR6)2, wherein each R6 is independently selected from an alkyl group containing from 1 to 4 carbon atoms and R4 is a branched or straight chain saturated or unsaturated hydrocarbyl group with zero to two double bonds and from 1 to 15 carbon atoms; X is O or CH2, with the proviso that when X is O, R can only be ?O; each Z is independently selected from (CH) and (CH2) y is a numeral selected from 1 and 2; R1 is selected from H or a branched or straight chain saturated or unsaturated hydrocarbyl group with zero to two double bonds and from 1 to 15 carbon atoms. R2 is selected from H and a branched or straight chain saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 15 carbon atoms.

Abstract: Medical use of natural and synthetic zeolites for treatment, prevention, and palliation in humans or animals of deleterious concentrations of ammonia, mercaptans, heavy metals and other toxins by oral administration.

Abstract: Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed.

Abstract: Disclosed is a hair care composition comprising cationic polymers and anionic particulates. The composition of the present invention provides improved deposition of anionic particulates.

Abstract: Emulsome compositions comprising phosphatidylcholine, cholesterol, tristearin, and one or more lipophilic bioactive agents such as vinpocetine are provided. The emulsomes may further comprise surface modifications of either [N-(carbonyl-methoxypropylethyleneglycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt] (MPEG-DSPE) for peglyation or stearylamine for cationization. Methods of improving brain delivery of lipophilic bioactive agents by intranasally administering such emulsome compositions are also provided.

Abstract: The present invention relates to pharmaceutical antiretroviral compositions comprising a combination of antiretroviral agents (darunavir, dolutegravir and ritonavir), the manufacturing process thereof and use of the said compositions for the prevention, treatment or prophylaxis of HIV infection.

Abstract: The present invention relates to a solid makeup and/or care cosmetic composition in the form of a compact powder, comprising, in a physiologically acceptable medium, at least: a pulverulent phase, an emulsifying system, a hydrophilic gelling agent, an organic lake, and a hydrophilic active agent with hygroscopic properties, which is present in a content of between 1% and 40% by weight relative to the total weight of the composition, the said composition having a solids content of greater than or equal to 90%. The invention also relates to a process for manufacturing this cosmetic composition from an intermediate composition comprising an aqueous phase, and to a process for coating the skin with the said cosmetic composition.

Abstract: Disclosed is a novel antimicrobial means which is effective against various types of fungi including pathogenic true fungi and phytopathogenic filamentous fungi. An antimicrobial agent against fungi according to the present invention comprises, as an effective ingredient, cyanoacrylate polymer particles having an average particle diameter of less than 1000 nm, which particles contain at least one selected from the group consisting of amino acids, amino acid derivatives, oligomers and polymers thereof, saccharides and polysorbates, and contain no antimicrobial active ingredient effective against the fungi. The antimicrobial agent is particularly useful as a control agent against plant diseases caused by filamentous fungi.

Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

Abstract: The subject matter of the invention is an autopolymerisable two-component prosthetic base material and a method for its production comprising A) at least one liquid monomer component, and B) at least one powdered component, whereby the prosthetic material comprises in components (A) and/or (B) (i) at least one initiator or one initiator system for autopolymerisation, (ii) core-shell particles modified by an elastic phase, and (iii) at least one urethane (meth)acrylate.