Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
Type:
Grant
Filed:
August 18, 1997
Date of Patent:
May 30, 2000
Assignee:
Euro-Celtique S. A.
Inventors:
Stewart Thomas Leslie, Trevor John Knott, Hasssan Mohammad, Derek Allan Prater