Abstract: 3-cyano-4-phenyl-pyrroles of the formula ##STR1## in which R stands for halogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio,have been found. These compounds are useful as fungicides.
Abstract: The present invention describes a protocol for achieving a very high degree of anticarcinogenic (or chemopreventive or cancer preventative) activity through the combination of a low suboptimal dose of a D-glucarolactone-based dietary anticarcinogen (i.e., calcium glucarate or CGT) with a low suboptimal dose of retinoid-based anticarcinogen (4-hydroxyphenyl retinamide or HPR). Since synergism is obtained by this combination, these two anticarcinogens can be employed at dosages far below toxic levels and at dosages that are practical as a food supplement.
Type:
Grant
Filed:
November 13, 1989
Date of Patent:
April 23, 1991
Assignee:
Ohio State University Research Foundation
Inventors:
John P. Minton, Thomas E. Webb, Hussein M. Abou-Issa
Abstract: The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.
Type:
Grant
Filed:
December 20, 1989
Date of Patent:
April 16, 1991
Assignee:
Aktiebolaget Hassle
Inventors:
Arne E. Brandstrom, Per L. Lindberg, Gunnel E. Sunden