Abstract: A method of producing a substance utilizing an agravic effect, and an apparatus for carrying out the same. A container (3, 55, 65) containing materials for producing a substance is revolved about a horizontal axis, at least while a process of producing the substance is in progress, so as to meet an inequality: ##EQU1## where .omega. (radian/sec) is the angular velocity of the container, g (mm/s.sup.2) is gravitational acceleration, r (mm) is the distance between a unit mass and an axis of rotation of the container rotating about its own axis to generate a residual centrifugal force acting on the unit mass, and x is the upper limit of the ratio between centrifugal force acting on the unit mass at each cycle and the terrestrial gravity (gravitational acceleration g).