Patents Examined by Philip I. Daltow - Justia Patents Search

Patents Examined by Philip I. Daltow

(1-azabicyclo[2.2.2]oct-3-yl) (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amine and n-(1-azabicyclo[2.2.2]o c

Patent number: 5576434

Abstract: Compounds of Formula 6: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen or together form .dbd.O.

Type: Grant

Filed: January 24, 1996

Date of Patent: November 19, 1996

Inventors: James Robinson, III, John C. Rohloff, Bruce A. Kowalczyk
Process for selectively producing an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7h-p yrido (1,2,3, -de) (1,4) benzoxazine-6-carboxylic acid hemihydrate or monohydrate

Patent number: 5545737

Abstract: A process for selectively producing an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3 -dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hemihydrate or monohydrate as depicted below, which comprises controlling the water content of an aqueous solvent in which an (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazin -yl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid is dissolved during a crystallization.

Type: Grant

Filed: January 18, 1994

Date of Patent: August 13, 1996

Assignee: Daiichi Pharmaceutical Co., Ltd.

Inventors: Yukio Sato, Atsushi Sato, Tatsuro Sumikawa, Tazuo Uemura