Abstract: A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.

Abstract: A syringe includes a plunger and a spring embedded in a viscoelastic material. Expansion of the spring and the viscoelastic material applies a force on the plunger to move the plunger distally in the syringe.

Abstract: An automatic drug delivery device is described, comprising: a housing (1); a skin sensor element (15) coupled to the housing and movable relative to the housing, wherein the skin sensor element is biased into a front position relative to the housing and is movable to a rear position relative to the housing when the skin sensor element is pressed against an injection site; a needle assembly comprising a hypodermic needle (11), the hypodermic needle extending outside of the housing when the device is in a needle insertion configuration; a drug delivery mechanism comprising a stored energy source (4), within the housing; wherein the drug delivery mechanism is released when the skin sensor element is moved from the front position towards the rear position and wherein the stored energy source is arranged to expand along an axis that is offset from an axis of travel of the needle assembly in use; a needle retraction mechanism configured to withdraw the hypodermic needle into the housing when the needle retraction m

Abstract: A composite expandable medical balloon comprising a base balloon, the base balloon comprising a coextrusion, the coextrusion comprising an inner layer formed from an elastomeric polymer and an outer layer formed from a thermoplastic polymer a fiber braid disposed along the base balloon, the fiber braid comprising at least one polymeric fiber disposed over the base balloon, wherein the base balloon is designed to exhibit minimal delamination between the inner layer the outer layer of the base balloon, and methods of making the same.

Abstract: A stretchy band that is placed over the plunger head of a syringe. The band is adhered to the underside of the plunger head. A thumb is snugly wrapped with the band to hold the thumb against the plunger head. The band is firmly secured around the thumb for operation of the syringe. A method of using this device is also disclosed.

Abstract: The invention provides a catheter and control box apparatus and related methods that are useful in delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the invention provides a catheter that stabilizes fluid flow within a vein to deliver a volume, pressure charge of saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The catheter and control box apparatus and related methods described herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.

Abstract: The invention relates to an injection device comprising an elongate housing and a cap removably mounted over a forward end of the housing. The cap comprising at least one slot extending forwardly from its rear edge; the at least one slot being configured to engage with an outwardly projecting protrusion on an outer surface of the housing when the cap is mounted on the housing. A rearward portion of the cap includes rearwardly extending engagement features provided on each side of the at least one slot, the engagement features being configured to locate within a cavity in the housing when the cap is mounted on the housing. The cavity is provided with corresponding surfaces which align with the cap engagement features so as to hold the outwardly projecting protrusion within the cut-out.

Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.

Abstract: Embodiments of the invention include methods of tissue/wound treatment and associated devices and systems, including devices for breaching bio-films contained in and around wounds, devices for maximizing moisture vapor transmission rate, and tissue dressings with added barrier features for permeable surfaces.

Abstract: The present invention relates to a respirator without breathing resistance, which has an air inlet duct that passes through an inside and an outside of the respirator and that has asymmetrical electrodes and particle capturing plates formed on an inner surface of the air inlet duct; ozone removing element that removes ozone generated by micro-plasma; and high voltage dc-dc converter that provides high voltage to the asymmetrical electrodes. It employs asymmetrical electrodes and particle capturing plates to filter air without generating breathing resistance. When the respirator according to the present invention is used, safety of a wearer may be maintained in accordance with an environment and breathing may be smoothly performed even while introduction of pathogenic bacteria, viruses, fungi, spores, fine dust, or the like included in air may be effectively blocked. Accordingly, the respirator may be widely utilized to maintain the safety of the wearer in various environments.

Abstract: Methods and devices are provided for inhibiting nerves when activating brown adipose tissue (BAT). In general, a first nerve type (e.g., sympathetic nerves) innervating BAT can be activated while at least one other nerve type (e.g., parasympathetic nerves and/or sensory nerves) innervating BAT is being suppressed. A first neuromodulator (e.g., an electrical signal, a chemical, a light, cooling, etc.) can be applied to activate the first nerve type, and a second neuromodulator can be applied to inhibit the at least one other nerve type. In this way, parasympathetic nerves and/or sensory nerves innervating BAT can be inhibited when activating sympathetic nerves innervating BAT.

Abstract: The present disclosure relates to a sensor for a capacitive determination of a filling level of a cartridge filled with a liquid substance. The sensor comprises a planar flexible foil arrangeable to an outer circumference of a tubular shaped barrel of the cartridge. The foil has at least a sensing zone, a communication zone and at least a first electrode. The foil further comprises least a second electrode located in the sensing zone, a processor electrically connected with the at least first and second electrodes, and an antenna located in the communication zone. The antenna is electrically connected with the processor.

Abstract: A phacoemulsification needle (100, 100A, 100B, 1000, 100D, 200, 200A) is provided for emulsifying body tissue. The needle (100, 100A, 100B, 1000, 100D, 200, 200A) is adapted to be attached to a phacoemulsification handpiece that imparts a vibration to the needle (100, 100A, 100B, 100C, 100D, 200, 200A). The needle (100, 100A, 100B, 1000, 100D, 200, 200A) has a body (104, 220, 220A) with a distal end (99), a proximal end (106), and an aspiration passage (124) extending between the proximal and distal ends (99, 106). The aspiration passage (124) defines a longitudinally-extending central body axis (110, 110A, 110B, 1100, 110D). The aspiration passage (124) is enlarged at the distal end (99) to define a tip (102, 102A, 102B, 1020, 102D, 210, 210A).

Abstract: A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.

Abstract: An adaptor for connecting a drug delivery device to a needleless access device having a straight external thread, including engagement means for mounting said adaptor on the drug delivery device, and an internal thread intended to cooperate with said external thread on a determined length, said internal thread showing on a distal part of said length a first major diameter mating that of said straight external thread, wherein said internal thread shows on a proximal part of said length a second major diameter, where the second major diameter is strictly smaller than the first major diameter, said internal thread further including a tapered portion linking said proximal part to said distal part.

Abstract: Methods and apparatuses are disclosed with regard to syringe-transfer of a solution or other fluid within a carpule. One embodiment includes an apparatus that is a non-standard carpule barrel having a top portion, a bottom portion, and a barrel portion therebetween. The top portion includes an opening for receiving a syringe plunger and at least a first portion of a connection mechanism for connecting to an upper portion of the syringe. The bottom portion includes another opening capable of holding a bottom end of the carpule, wherein the carpule may be a standard carpule or a non-standard carpule. The barrel portion is located between the top portion and bottom portion, wherein the barrel portion includes a cradle, and wherein the cradle has a length capable of holding a standard carpule or a non-standard carpule and a width greater than the standard carpule.

Abstract: A peristaltic pump (200) is proposed which comprises a first housing component (210) and a second loading component (230), said second loading component being at least partially contained within said first housing component and being axially movable with respect to said first housing component inside thereto. The second loading component further comprises at least a couple of rollers (235) which engage and squeeze a delivery tube (146) for delivering a fluid passing there through when, in operation, the second loading component is fully snapped into said first housing component. Moreover the second loading component comprises a guiding path (240) for guiding the delivery tube around said at least a couple of rollers towards an exit port (244) which is provided at a distal end surface of the second loading component. The present invention also relates to a patient set and to an injection system comprising said peristaltic pump, as well as to a method of operating said injection system.

Abstract: An autoinjector device is disclosed which comprises a body portion and a syringe carrier, for supporting a syringe with a needle at its forward end. The syringe carrier is moveably mounted within the housing such that forward movement relative to the housing may extend the needle from a forward end of the body. The syringe carrier has a latch element arranged to cooperate with a corresponding retention feature of the body portion to releasably hold the syringe carrier in a rearward position within the body potion. A delivery mechanism is arranged to forwardly displace the syringe carrier relative to the housing and to deliver a dose of medicament from the syringe. A shroud assembly is provided at a forward end of the device. The shroud further comprises a locking arrangement which blocks releasing movement of the latch element from the retention feature when the shroud is in a first, forward position and is unlocked when the shroud is in a second, rearward position.

Abstract: An inflatable structure for use in biological lumens and methods of making and using the same are disclosed. The structure can have an inflatable balloon encircled by a shell. The shell can have proximal and distal tapered necks, longitudinally-oriented flutes, and apertures at the proximal and distal ends of the shell. The apertures can be recessed in the flutes in the necks. The shell can also have fiber reinforced walls.

Abstract: The invention generally relates to an auxiliary guidewire for an intravascular procedure. The invention provides an auxiliary guidewire that slips over a primary guidewire and can provide a very fine extension beyond the end of the primary guidewire. The primary guidewire can be taken to its limit within the fine vasculature, and the auxiliary guidewire can then extend further into the fine vasculature. The primary guidewire can be taken to a bifurcation. The primary guidewire and the auxiliary guidewire can be sent down separate branches of the bifurcation. A physician can select which of the primary guidewire and the auxiliary guidewire are within the branch that needs to be treated by, for example, consulting an angiography display.