Abstract: An interventional device for cutting tissue at a targeted cardiac valve, such as a mitral valve. The interventional device includes a catheter having a proximal end and a distal end. A cutting mechanism is positionable at the distal end, such as by routing the cutting mechanism through the catheter to position it at the distal end. The cutting mechanism includes one or more cutting elements configured for cutting valve tissue when engaged against the tissue. A handle is coupled to the proximal end of the catheter and includes one or more controls for actuating the cutting mechanism.

Abstract: A method for closing an opening in biological tissue of intra-abdominal structures, which includes the steps of (i) providing a tissue closure system that includes a suture guide sub-system for engaging tissue disposed proximate the tissue opening and a suture passer sub-system that slideably engages the suture guide sub-system, (ii) inserting the suture guide sub-system into and through a tissue opening, (iii) inserting the suture passer sub-system with a section of suture engaged thereto into and through a first tissue region, (iv) rotating the suture guide sub-system, (v) inserting the suture passer sub-system with another section of suture engaged thereto into and through a second tissue region, (vi) withdrawing suture guide sub-system, (vii) releasing both sections of the suture captured by the suture guide sub-system, and (viii) drawing both sections of the suture together, wherein the first and second tissue regions are drawn together and the tissue opening is closed.

Abstract: The invention provides a filter assembly including a string or wire such that a lasso type cincture is effected, said filter being openable and closeable while in deployed within a bodily vessel. A string lengthen or shorting adjustment mechanism, such as a ratchet or reel allows more length of string into the device or alternatively to shorten the length of available string in the system. The described invention, when used to ameliorate venous clots and most arterio-venous dialysis grafts, a filter-tipped aspirator is used downstream from the clot to capture and remove dislocated emboli. A method of using same is disclosed.

Abstract: The invention provides a filter assembly including a string or wire such that a lasso type cincture is effected, said filter being openable and closeable while in deployed within a bodily vessel. A string lengthen or shorting adjustment mechanism, such as a ratchet or reel allows more length of string into the device or alternatively to shorten the length of available string in the system. The described invention, when used to ameliorate venous clots and most arterio-venous dialysis grafts, a filter-tipped aspirator is used downstream from the clot to capture and remove dislocated emboli. A method of using same is disclosed.

Abstract: An occlusion device intended for blocking perivalvular leak channels that are found following heart valve implantation between the heart valve and the surrounding tissue. The occlusion device has a stent and a covering that is attached to the stent surface. A blocking fabric extends across the lumen of the stent to block blood flow. The stent pattern and wall structure provide for small radius of curvature bends to fill narrow channels that cause the perivalvular leaks.

Abstract: Methods for delivering a replacement heart valve include advancing a delivery system through a femoral vein and into the atrium of a heart, wherein the delivery system includes an outer sheath assembly, a mid shaft assembly and an inner assembly. The outer sheath assembly and the mid shaft assembly are adapted to retain the replacement heart valve in a radially compacted state over the inner assembly. The outer sheath assembly is retracted to allow a plurality of distal anchors to self-expand while a portion of the replacement heart valve remains retained in a compacted state by the mid shaft assembly. The distal anchors are positioned to engage one or more native leaflets and the retained portion of the replacement heart valve is then released and allowed to fully expand for implanting the replacement heart valve within the native valve.

Abstract: A method of occluding an aneurysm includes positioning a braided implant within an aneurysm sack such that an outer non-inverted layer contacts a wall of the aneurysm and an inverted layer apposes the outer non-inverted layer to form a double layer of braid across a neck of the aneurysm. A radiopaque end of the braided implant can be positioned centrally within the aneurysm so that the radiopaque end extends adjacent or across a plane defined by a fold between the outer non-inverted layer and the inner inverted layer. Embolic coils can be inserted into the aneurysm sac and inhibited from exiting the aneurysm at the neck by the double layer braid across the aneurysm neck.

Abstract: A knotting assembly for surgical suture line has an outer tube and an inner tube being slidably mounted in the outer tube. The inner tube protrudes from the outer tube and forms a loop section between a distal end thereof and a distal end of the outer tube. A suture line is looped surround the loop section to form a pre-knot and a loop. The suture has an inner section being moveably inserted in the inner tube. The loop is inserted by at least one second suture line. While the inner section is pulled, the second loop is closed to hold the at least one second suture line and folds the second suture line and pulls the folded second suture into the inner tube to finish the knot.

Abstract: Devices, systems, implants and methods for achieving ligament fixation are disclosed. An implant includes a head member and an anchor member coupled to the head member. The implant includes tension member that couples the head member to the anchor member. The head member and the anchor member include a cannulation that receives the tension member therein. The implant may include a coupling member positioned between and coupling the head member and the anchor member, the coupling member including a cannulation that receives the tension member therethrough. Insertion instruments for inserting an implant for ligament fixation are also disclosed. Methods of using an implant for achieving ligament fixation are also disclosed.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to single-use endoscopic medical devices with integrated and purpose-built functionality.

Abstract: This invention relates to devices that join a pair of edges. Previously, suture assemblies used holes perpendicular to a vertical plane. Embodiments of the present invention use a first pad tunnel (130) between a first pad lower plane opening (126) and a first pad upper plane opening (122). A first pad tunnel major axis (132) passes through a first pad upper plane opening center (124) and a first pad lower plane opening center (128). For reference a first pad orthogonal axis (134) passes through the first pad upper plane opening center (124) orthogonal to the first pad upper plane (118) and the first pad lower plane (120). A first pad angle (?1) is measured clockwise from the first pad orthogonal axis (134) to the first pad tunnel major axis (132). The first pad angle is at least five degrees but no more than 175 degrees.

Abstract: Apparatus for excising and removing a clip or suture joining leaflets of a native heart valve. The apparatus includes an elongate shaft configured for remote access to a native heart valve, the elongate shaft having a proximal end, a distal end, and a lumen defined therein, and a clamp at the distal end of the elongate shaft, the clamp configured to receive a clip or suture joining native leaflet tissue, the clamp including a passageway extending along a length thereof in communication with the lumen. The apparatus further includes a cutter moveable within the passageway to encompass a clip or suture joining native leaflet tissue received within the clamp and cut native leaflet tissue proximate the clip or suture.

Abstract: A prosthesis for implantation at a native semilunar valve includes a prosthetic distal valve, which includes a pliant material configured to collapse inwardly towards a longitudinal axis of the prosthesis during diastole, and to open outwardly during systole, and a distal fixation member configured to be positioned in a downstream artery of the subject. The apparatus also includes a proximal fixation member coupled to the distal fixation member, and configured to be positioned at least partially on a ventricular side of the native semilunar valve. The proximal fixation member is shaped so as to define a lattice that is shaped so as to define an intermediary portion that is coupled to the pliant material of the valve and diverges outwardly from the longitudinal axis, and a distal portion that is distal to the intermediary portion and diverges outwardly from the intermediary portion of the lattice. Other embodiments are also described.

Abstract: The present subject matter discloses a tissue removal tool for use with an endoscope. The tool comprises a loop formed by a piece of wire and movable between an open position and a closed position, and a transmitting assembly comprising: a handle; and a link having a first end attached to the handle and a second end attached to the loop, the loop portion being movable between the open and closed position by action of the handle. The loop is defined in the open position by a proximal portion and a distal portion. The widest portion of the loop is more proximal to a proximal end of the loop than the mid-point of the length of the loop is.

Abstract: The present disclosure relates to a braid for treating an aneurysm. The braid can include a proximal expandable portion for positioning inside the aneurysm and sealing across a neck of the aneurysm. The braid can also include a distal expandable portion distal of the proximal expandable portion, the distal expandable portion for filling the aneurysm.

Abstract: Implantable medical devices for connecting tissue layers or occluding body conduits and tissue structures include apposition portions, a central region, and a covering material. The methods of using the devices include endoscopic deployment, and the devices may include self-expanding frameworks that facilitate a secure connection between the tissue structures. In some embodiments, one or more tethers are used to longitudinally contract the device in situ.

Abstract: The present invention reveals a needle set of laparoscopic surgery and knotting device thereof, the needle set comprising a body and an axis sleeve. Near the body side is formed a barrier, and the other side have a concave groove. The axis sleeve is hollow tube and fixedly run through the body. Therefore the needle set can axial insert into to the axis sleeve, and achieve the effect that minimizing the complicate of overall structure, reducing the length of a knotting device, and more convenient to operate.

Abstract: A fluid management system for use in a tissue resection procedure includes a controller. An inflow pump is operated by the controller and configured to provide fluid inflow through a flow path to a site in patient's body. An outflow pump is operated by the controller and configured to provide fluid outflow through a flow path from the site in patient's body. A motor driven resecting device may be provided for resecting tissue at the site. The controller is configured to actuate an inflow pump and an outflow pump in response to various signals and various algorithms are provided to provide malfunction warnings and assure safe operation.

Abstract: Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.

Abstract: Various aspects of the present disclosure are directed toward systems, methods, and apparatuses that include an occlusion device having a barrier member. The barrier member may include an enlargeable portion and a tail portion extending from the enlargeable portion. The enlargeable portion and the tail portion are releasably coupled to the delivery catheter such that the tail portion is radially unsupported and collapsible upon deployment.