Abstract: The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Abstract: Systems, methods, and computer-readable storage media are described for generating a virtual keyboard user interface with at least one multi-state display portion. The user interface may include a plurality of keys of a virtual keyboard generated on a display, with at least one key among the plurality of keys having a first function. The user interface may also include a mnemonic device configured to be displayed on the virtual keyboard, where the mnemonic device may be irrelevant to the first function. The mnemonic device may have a first display state when the at least one key is not selected, and have a second display state when the at least one key is selected. In some aspects, the mnemonic device has a reduced visibility in the first display state and a heightened visibility in the second display state, so as to emphasize the second display state.

Abstract: A computer-implemented method, computer program product, and system is provided for creating calculated metrics. In an implementation, a method may include providing a user interface including a calculator with a plurality of buttons. The method may also include receiving, via the user interface, a selection of at least one stored metric and a selection of at least one operation, resulting in a new metric. The method may further include storing the new metric with a new metric name.

Abstract: A sequence of tuples, each having one or more attributes, is received at one of one or more processing elements operating on one or more processors. Each processing element may have one or more stream operators. A first stream operator may be identified as one that only processes an instance of a first attribute in a currently received tuple when a difference between an instance of the first attribute in a previously received tuple and the instance of the first attribute in the currently received tuple is outside of a difference threshold. A second stream operator may generate a difference attribute from a first instance of the first attribute in a first one of the received tuples and a second instance of the first attribute in a second one of the received tuples. The difference attribute may be transmitted from the second stream operator to the first stream operator.

Abstract: A system and method for sharing data and resources among a plurality of applications on a mobile device is disclosed. Embodiments provide a mobile applications architecture that is able to link applications and share the linked applications simultaneously on an Android (or other operating system) mobile device such as a smart phone or table computer. The mobile applications architecture creates a framework that provides an easy interface for third-party applications to quickly integrate and leverage already constructed components and sharing of data among multiple third-party applications thereby reducing the complexity of newly developed capabilities for mobile applications architecture on not just a single device, but multiple devices.

Abstract: The system includes an apparatus which automatically measures an inventory of a consumable good and tracks the inventory as it is used. The system may include a signaling device which creates a signal when a defined minimum amount of the consumable good has been reached. The apparatus may also send the user an electronic message that the defined minimum has been reached. The system may then automatically submit an order to a supplier for a replacement supply of the consumable good. This system may be used to track supply and reorder animal food, food staples, production supplies, manufacturing parts, or virtually any consumable good. Accordingly, a user may avoid the inconvenience and loss of time and money due to failure to timely replace a consumable good.

Abstract: A dynamic hash partition management scheme includes associating first partitions of a database with a first partition number, and second partitions of the database with a second partition number, associating first partitions of a database with a first partition number defining a total number of first partitions, and second partitions of the database with a second partition number defining a total number of second partitions. The method further includes, after receiving a request to insert a record in the database, determining an active partition number, and determining the first partition number as an active partition number. The method further includes determining a record key for the record, generating a partition identifier defining a partition of the first partitions using the record key and the active partition number, and inserting the record in the partition defined by the partition identifier.

Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

Abstract: A computer-implemented method, computer program product, and system is provided for creating calculated metrics. In an implementation, a method may include providing a user interface including a calculator with a plurality of buttons. The method may also include receiving, via the user interface, a selection of at least one stored metric and a selection of at least one operation, resulting in a new metric. The method may further include storing the new metric with a new metric name.

Abstract: A soybean variety, designated 5PGAW71 is provided. Also provided are the seeds of soybean variety 5PGAW71, cells from soybean variety 5PGAW71, plants of soybean 5PGAW71, and plant parts of soybean variety 5PGAW71. Methods provided include producing a soybean plant by crossing soybean variety 5PGAW71 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PGAW71, methods for producing other soybean varieties or plant parts derived from soybean variety 5PGAW71, and methods of characterizing soybean variety 5PGAW71. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PGAW71 are further provided.

Abstract: Extracellular drug conjugates (EDCs) targeting CD38 are useful in the treatment of diseases such as cancer and immune disorders, including asthma.

Abstract: Provided is a process including: obtaining a graph comprising nodes and edges, each of the edges having a value indicating an amount of similarity between objects corresponding to the two linked nodes; selecting a parameter for influencing the graph; assessing each of the nodes based on the selected influencing parameter, wherein assessing comprises, with respect to each adjacent node in the graph sharing an edge with the node: determining the value indicating the amount of similarity between the object corresponding to the node and the object corresponding to the adjacent node; and determining a score related to the edge shared with the node, the score determined based on the similarity-amount value and a value of the selected influencing parameter for the node, such that edges are removed, weakened, added, or strengthened; and preparing, based on the graph, instructions to display at least part of the graph.

Abstract: A timing estimation device according to the present invention includes a received signal memory that outputs a plurality of sample groups each of which is a first number of samples extracted at symbol rate intervals from an oversampled received signal containing a known sequence, with shifting their leading positions by one sample from each other, a reliability calculation unit that calculates a channel impulse response for each of the sample groups, based on the sample group, generates a replica of the received signal using the channel impulse response and the known sequence, and calculates a reliability value based on the sample group, the replica, and the channel impulse response, and a timing estimation unit that estimates a preceding wave arrival timing and a delayed wave arrival timing, based on the reliability value.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may determine, based at least in part on a set of channel state information reference signals (CSI-RSs), a plurality of hypotheses associated with a plurality of transmission/reception points (TRPs), wherein the UE is configured to receive non-coherent transmissions across the plurality of TRPs according to at least one of a transparent transmit diversity scheme, a non-transparent transmit diversity scheme, or a closed-loop block diagonal precoder scheme, and wherein a coherent precoder is configured within each of the plurality of TRPs. In some aspects, the UE may determine, based at least in part on the plurality of hypotheses, channel state information (CSI) feedback associated with the plurality of TRPs. Numerous other aspects are provided.

Abstract: A method to determine the heading or orientation of a target vehicle by a host vehicle, said host vehicle equipped with a lidar or radar system, said system including a sensor unit adapted to receive signals emitted from said host vehicle and reflected by said target vehicle, comprising: a) determining at least one reference angle being an initial estimate of target heading or orientation (?); b) emitting a signal from said system and determining a plurality of point radar or lidar detections belonging to said a target vehicle, said point detections having co-ordinates in the horizontal plane; c) formulating an initial rectangular boundary box from said point detections, where the bounding box is formulated such that such that two edges of the boundary box are drawn parallel to the reference angle and two sides are perpendicular to the reference angle and such that all the detections are either on the bounding box sides or lay within the bounding box and each edge has at least one detection point on it; d) fo

Abstract: The invention relates to a method and apparatus for controlling one or more controllable devices (5, 6, 7, 38, 39, 40) in a system. In order to provide the apparatus with a more user friendly interface to control the one or more controllable device in the system, the method comprises capturing an image (50), comprising the one or more controllable devices, displaying the captured image (50), associating local areas (105,106,107,108,109,110) in the captured image (50) to the one or more respective controllable devices (5,6,7,38,39,40) on basis of information associated with the controllable devices in the captured image, receiving a user input indicating a selected one of the local areas in the displayed image, determining a command for the one or more controllable devices from the user input associated with the selected local area; and communicating the command to the one or more controllable devices.

Abstract: An electrical terminal is presented herein. The electrical terminal includes a base plate, a plurality of contact arms extending from the base plate around a longitudinal axis, and a wire attachment feature extending from the base plate and defining crimp wings configured to mechanically and electrically attach the electrical terminal to a wire cable. The plurality of contact arms form a socket configured to receive a mating electrical terminal. An electrical connector assembly including the electrical terminal and a method of forming the electrical connector assembly is also presented.

Abstract: Disclosed herein is a cooking system for cooking food, the system including a housing defining a hollow chamber configured to receive a food container. The housing has an upper portion defining an opening to the hollow chamber. A lid is movable relative to the housing. The lid contacts the housing in a closed position about the upper portion of the housing to close the opening to the hollow chamber. At least one heating element is associated with at least one of said housing and said lid. The cooking system is operable in a plurality of cooking modes including a pressure cooking mode and a dry cooking mode. In the pressure cooking mode, the cooking system is operable as a pressure cooker and in the dry cooking mode, the cooking system is operable as a dry cooker.

Abstract: A method for predicting the residual useful life of an air filter arrangement is described. The method includes the following steps: providing a plurality of predetermined reference degradation curves; measuring a degradation parameter of the filter arrangement; and estimating the residual useful life of the filter arrangement by comparing the predetermined reference degradation curves and an actual degradation curve defined by measured values of the degradation parameter.

Abstract: An electrical connector assembly includes an electrical terminal having an attachment end and a connection end, a first terminal housing having a first cavity in which the attachment end is disposed. The first cavity defining a terminal extension opening through which the connection end extends. The assembly also includes a second terminal housing having a second cavity in which the connection end is disposed. The second cavity defining a terminal reception opening through which the connection end is received. The first terminal housing defines a first attachment surface surrounding the terminal extension opening and the second terminal housing defines a second attachment surface surrounding the terminal reception opening. The first attachment surface is sealed to the second attachment surface. The first attachment surface forms a first angle relative to the longitudinal axis and the second attachment surface forms a second angle relative to the lateral axis.