Patents Examined by Phyllis G. Spivack
  • Enteric medicinal composition for oral use
    Patent number: 7678817
    Abstract: An enteric medicinal composition comprising a drug ingredient, pectin, alginic acid, or a derivative thereof, and water is provided that is easy to swallow.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 16, 2010
    Assignee: MEDRX Co., Ltd.
    Inventors: Noboru Tatsumi, Hidetoshi Hamamoto, Masaki Ishibashi, Kanako Shiota, Sueko Matsumura, Keiko Yamasaki
  • Compositions for the treatment of overactive bladder
    Patent number: 7678821
    Abstract: Disclosed herein are pharmaceutical compositions comprising combinations of tolterodine, an antimuscarinic agent, and pilocarpine, a compound that causes stimulation of salivary glands. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient said pharmaceutical composition.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: March 16, 2010
    Assignee: TheraVida, Inc.
    Inventor: Mehdi Paborji
  • Stabilized formulation of ivermectin feed premix with an extended shelf life
    Patent number: 7671034
    Abstract: The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: March 2, 2010
    Assignee: Merial Limited
    Inventor: Keith Allan Freehauf
  • Therapy for the treatment of disease
    Patent number: 7666894
    Abstract: Disclosed herein are pharmaceutical compositions comprising oxybutynin, or a free base thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof or a pharmaceutically acceptable salt thereof. Also disclosed are methods of treating a patient suffering from overactive bladder comprising administering to the patient the above pharmaceutical composition.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: February 23, 2010
    Assignee: TheraVida, Inc.
    Inventor: Mehdi Paborji
  • Method of increasing gastric emptying
    Patent number: 7659306
    Abstract: The invention discloses the administration of nafadotride partially reverse the effect of dopamine on gastric emptying in patients suffering from gastroesophageal reflux.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: February 9, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Pankaj Jay Pasricha, Maria-Adelaide Micci
  • Method for increasing the bioavailability of glycopyrrolate
    Patent number: 7638552
    Abstract: The invention relates to a method of increasing the bioavailability of glycopyrrolate by administration of a therapeutically effective amount of glycopyrrolate without food. The invention also provides a kit comprising a pharmaceutical composition comprising a therapeutically effective amount of glycopyrrolate and a pharmaceutically acceptable carrier, prescribing information including advice regarding the administration of glycopyrrolate without food to improve bioavailability, and a container.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: December 29, 2009
    Assignee: Sciele Pharma, Inc.
    Inventors: Alan Roberts, Balaji Venkataraman
  • Methods of treating dyschezia
    Patent number: 7635714
    Abstract: A compound of Formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a C1-C6 alkyl group and R2 represents a C1-C6 alkyl group, while unlike a laxative, is effective in the treatment of constipation.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: December 22, 2009
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kenshi Kamei, Hirokazu Sudo, Kenichi Ozaki, Osamu Cynshi, Hideki Sato
  • Arylalkylcarbamate derivatives and production thereof
    Patent number: 7632850
    Abstract: The present invention provides a compound of the formula (I): in which R1, R2, R3, A and n are described and set forth more fully herein. Also provided are their preparation and their application in therapy.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: December 15, 2009
    Assignee: Sanofi-aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Christian Hoornaert, Antoine Ravet
  • Andrographolide and analogues as inhibitors of TNF? and IL-1? expression
    Patent number: 7625945
    Abstract: This invention relates to a method of inhibiting the expression of TNF? or IL-1? with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: December 1, 2009
    Assignee: Hutchison MediPharma Enterprises Ltd.
    Inventors: Xiaoqiang Yan, Tao Wang, Zhiming Ma, Ke Pan, Weihan Zhang, Jianrong Hong, Jeff Duan, Yu Cai
  • Method of treating dermatitis comprising administering a chymase inhibitor
    Patent number: 7618977
    Abstract: Medicaments for the treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, having quinazolidone derivatives of formula I or II that are herein defined, are disclosed.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: November 17, 2009
    Assignee: Asubio Pharma Co., Ltd.
    Inventors: Harukazu Fukami, Yoshiaki Tomimori, Yoshiaki Fukuda, Naohiro Watanabe
  • Method of treatment for irritable bowel syndrome
    Patent number: 7601756
    Abstract: A method for treating irritable bowel syndrome (IBS) is included. The method includes the step of administering a fibric acid derivative to a patient diagnosed with IBS in order to alleviate the symptoms associated with IBS.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: October 13, 2009
    Assignee: Snowden Pharmaceuticals, LLC
    Inventor: Peter Sterling Mueller
  • Method of inhibiting intestinal polyps
    Patent number: 7572775
    Abstract: The present invention provides a method for reducing the occurrence and progress of intestinal polyps that may develop into colon cancer, and a carboxylic acid amide compound as an active component to reduce intestinal polyps, represented by the following Formula: wherein R is a lower alkyl group and X is a halogen an example being 4-diethoxyphosphinoylmethyl-N-(4-bromo-2-cyanophenyl) benzamide.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: August 11, 2009
    Assignees: Japan as Represented by Director General of Agency of National Cancer Center, Otsuka Pharmaceutical Factory, Inc.
    Inventors: Keiji Wakabayashi, Michihiro Mutoh
  • Use of pagoclone for the treatment of social anxiety disorder
    Patent number: 7553847
    Abstract: The present invention provides methods for treating social anxiety disorder, comprising administering 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone or 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-5-hydroxy-2-oxohexyl) -1-isoindolinone or pharmaceutically acceptable salt, or optical isomer therof, and optionally comprising administering another compound for the treatment of social anxiety disorder that is a GABA agonist.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: June 30, 2009
    Assignee: Indevus Pharmaceuticals, Inc.
    Inventors: Cathryn M. Clary, Jeroen Van Beek, Perry S. Eisman, Sean Donevan, Atul Pande, Richard Kavoussi, Lyou-Fu Ma
  • Use of an IBAT inhibitor for the treatment of constipation
    Patent number: 7514421
    Abstract: A method of treatment of functional constipation or C-IBS in a warm-blooded animal is disclosed, which comprises the administration of an IBAT inhibitor.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: April 7, 2009
    Assignee: Albireo AB
    Inventors: Hasse Roland Abrahamsson, Per-Goran Gillberg
  • Methods for treating digestive functional pathologies
    Patent number: 7452877
    Abstract: Methods are disclosed for treating hyperalgesia associated with irritable bowel syndrome comprising administering a direct and selective inhibitor of MLCK.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: November 18, 2008
    Assignee: Rytek
    Inventor: Lionel Bueno
  • Phenoxyalkycarboxylic acid derivatives in the treatment of interstitial cystitis
    Patent number: 7429617
    Abstract: A method of treating interstitial cystitis is disclosed comprising administering to a patient in need thereof an effective amount of a compound selected from compound 1, its metabolite 2 and pharmaceutically acceptable salts thereof:
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: September 30, 2008
    Assignee: Medicinova, Inc.
    Inventors: Kenneth Walter Locke, Charles G. Smith, Takashi Kiyoizumi
  • Parenteral and oral formulations of benzimidazoles
    Patent number: 7419996
    Abstract: Pharmaceutical compositions of a benzimidazole or a benzimidazole derivative are disclosed. For example, in certain embodiments the pharmaceutical compositions include a benzimidazole, PEG 400, and a dipolar aprotic solvent. In other embodiments, pharmaceutical compositions include a benzimidazole, an oil, a dipolar aproptic solvent, and a surfactant. In certain embodiments, the benzimidazole is mebendezole. The pharmaceutical compositions are formulated for delivery to a subject by any means, and include formulations for oral and parenteral delivery.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: September 2, 2008
    Assignee: The University of Houston
    Inventors: Diana Shu-Lian Chow, Dong Liang
  • Method and composition for selectively inhibiting melanoma
    Patent number: 7414042
    Abstract: Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally applied topically is inserted therefor.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: August 19, 2008
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: John M. Pezzuto, Tapas K. DasGupta, Darrick S. H. L. Kim
  • Treating agent for irritable bowel syndrome
    Patent number: 7358270
    Abstract: A therapeutic method and pharmaceutical compositions for treatment of irritable bowel syndrome including non-constipated irritable bowel syndrome such as diarrhea-predominant irritable bowel syndrome and alternating constipation/diarrhea irritable bowel syndrome in male and female patients, which may comprise administering a patient with from 0.001 to 0.05 mg of ramosetron hydrochloride as a daily dose or an equivalent molar amount of ramosetron or its pharmaceutically acceptable other salt.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: April 15, 2008
    Assignee: Astellas Pharma Inc.
    Inventors: Akito Nishida, Akira Niwa, Yutaka Atsuta
  • Use of carbazole compounds for the treatment of congestive heart failure
    Patent number: RE40707
    Abstract: A method of treatment using carvedilol is disclosed, wherein the carvedilol decreases the risk of mortality caused by congestive heart failure in patients. The patients are titrated with low amounts of carvedilol, with the initial titration dosage being only 10 to 30% of the daily maintenance dose.
    Type: Grant
    Filed: February 7, 1996
    Date of Patent: May 5, 2009
    Assignee: SB Pharmco Puerto Rico Inc.
    Inventors: Mary Ann Lukas-Laskey, Robert Ruffolo, Jr., Neil Howard Shusterman, Gisbert Spooner, Klaus Strein