Patents Examined by Ponnathapu Achutamurthy
  • Steroid hormone receptor interacting protein kinase
    Patent number: 6673586
    Abstract: The present invention features a novel p21-activated kinase that interacts with steroid hormone receptors, the steroid hormone receptor interacting p21-activated kinase (PAKSI). In general, the invention provides methods of inhibiting hormone related cancers. More particularly, the present invention relates to inhibiting prostate cancer and breast cancer. The present invention further provides methods of activating the therapeutic effects of steroid hormone receptors, particularly the estrogen receptor. Alternatively, the present invention provides methods of diagnosing steroid hormone receptor-related diseases.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: January 6, 2004
    Assignee: Beth Israel Deaconess Medical Center
    Inventor: Steven Balk
  • Multiply-substituted protease variants with altered net charge for use in detergents
    Patent number: 6673590
    Abstract: Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Protease variants are provided that contain substitutions of the amino acids at one or more residue positions so that the substitution alters the charge at that position to make the charge more negative or less positive compared to a precursor protease and thus the protease variant is more effective in a low detergent concentration system than a precursor protease.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: January 6, 2004
    Assignee: Genencor International, Inc.
    Inventors: Ayrookaran .J. Poulose, Volker Schellenberger, James T. Kellis, Jr., Christian Paech, Joanne Nadherny, Donald P. Naki, Katherine D. Collier, Robert M. Caldwell
  • Compositions comprising bioactive peptides prepared without formation of native disulfide bonds
    Patent number: 6670148
    Abstract: A method of preparing a bioactive polypeptide in a stable, inactivated form, the method comprising the step of treating the polypeptide with ozonated water in order to oxidize and/or stabilize the cysteine residues, and in turn, prevent the formation of disulfide bridges necessary for bioactivity. The method can involve the use of ozonated water to both oxidize the disulfide bridges in a bioactive polypeptide, and to then stabilize the resultant cysteine residues. Optionally, and preferably, the method can involve the use of ozonated water to stabilize the cysteine residues, and thereby prevent the formation of disulfide bridges, in a polypeptide produced by recombinant means in a manner that allows the polypeptide to be recovered with the disulfide bridges unformed.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: December 30, 2003
    Assignee: BioTherapeutics, Inc.
    Inventors: David D. Mundschenk, Leonard A. Smith
  • Polynucleotide encoding a diaminopimelate epimerase from Corynebacterium glutamicum
    Patent number: 6670156
    Abstract: The present application is directed to a diaminopimelate epimerase from Corynebacterium glutamicum and to polynucleotides encoding this enzyme. The gene has been given the designation “dapF.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: December 30, 2003
    Assignee: Degussa AG
    Inventors: Bettina Möckel, Walter Pfefferle, Brigitte Bathe, Jorn Kalinowski, Oliver Kirchner, Michael Hartmann, Alfred Pühler
  • &agr;1,2-fucosyltransferase
    Patent number: 6670160
    Abstract: A bacterial &agr;1,2-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing &agr;1,2-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, Lewis B and H type 1, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: December 30, 2003
    Assignee: Governors of the University of Alberta
    Inventors: Diane Taylor, Ge Wang, Monica Palcic
  • Enzymatic reduction of cobalt in cobalamin
    Patent number: 6670152
    Abstract: It is disclosed that the enzymes ATP:corrinoid adenosyltransferase (CobA) from Salmonella typhimurium and reduced flavodoxin (FldA) from E. coli are both necessary and sufficient, in the presence of ATP, to reduce the oxidation state of the cobalt atom in cobalamin and produce adenosylcobalamin. This makes possible the construction of plasmids to confer upon microbial fermentation hosts the ability to synthesize adenosylcobalamin, the supply of which can sometimes be a limitation on microbial growth in fermentation. Since the enzyme flavodoxin reductase (Fpr), also from E. coli, can act to reduce FldA for biological activity, that enzyme should preferably be expressed in a fermentation host as well.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: December 30, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jorge C. Escalante-Semerena, Maris V. Fonseca
  • Processes for preparing D-pantothenic acid using coryneform bacteria
    Patent number: 6667166
    Abstract: The present invention provides processes for preparing D-pantothenic acid using Coryneform bacteria having an enhanced pfkA gene.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: December 23, 2003
    Assignee: Degussa AG
    Inventors: Georg Thierbach, Nicole Dusch
  • Sequences of Xylanase and Xylanase expression vectors
    Patent number: 6667170
    Abstract: The production of thermostable xylanses having bacterial origin is described. These compositions are useful for modifying plant biomass and for enzyme-aided bleaching of wood pulp.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: December 23, 2003
    Assignee: Röhm Enzyme Finland Oy
    Inventors: Arja Mäntylä, Marja Paloheimo, Raija Lantto, Richard Fagerström, Tarja Lahtinen, Pirkko Suominen, Jari Vehmaanperä
  • 38692 and 21117, novel dual specificity phosphatase molecules and uses therefor
    Patent number: 6664089
    Abstract: The invention provides isolated nucleic acids molecules, designated 38692 or 21117 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38692 or 21117 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38692 or 21117 gene has been introduced or disrupted. The invention still further provides isolated 38692 or 21117 proteins, fusion proteins, antigenic peptides and anti-38692 or 21117 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: December 16, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Rachel A. Meyers
  • Isolated nucleic acid molecules encoding human glucuronyltransferase proteins, and related products and processes
    Patent number: 6664084
    Abstract: The present invention provides amino acid sequences of human glucuronyltransferase proteins and nucleic acid sequences encoding these glucuronyltransferase proteins. The present invention provides isolated glucuronyltransferase proteins and encoding nucleic acid molecules, vectors and host cells containing these nucleic acid molecules, and processes for producing the glucuronyltransferase proteins.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: December 16, 2003
    Assignee: Applera Corporation
    Inventors: Weiniu Gan, Chunhua Yan, Gennady V. Merkulov, Valentina Di Francesco, Ellen M. Beasley
  • Genes involved in isoprenoid compound production
    Patent number: 6660507
    Abstract: Genes have been isolated from Methylomonas 16a sp. encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from a Methylomonas strain that is capable of utilizing single carbon (C1) substrates as energy sources. The genes and gene products of the present invention may be used in a variety of ways for the production of isoprenoid compounds in a variety of organisms.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: December 9, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Qiong Cheng, Mattheos Koffas, Kelley C. Norton, James M. Odom, Stephen K. Picataggio, Andreas Schenzle, Jean-Francois Tomb, Pierre E. Rouviere
  • Methods of screening for modulation of cell cycle
    Patent number: 6660511
    Abstract: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: December 9, 2003
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ying Luo, Xiang Xu
  • Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom
    Patent number: 6660510
    Abstract: The invention provides a DNA molecule encoding transglutaminase of Streptoverticillium ladakanum, the encoded transglutaminase and the use of the transglutaminase in industrial process.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: December 9, 2003
    Assignee: Food Industry Research and Development
    Inventors: Yi-Shin Lin, Chang-Hsiesh Liu, Wen-Shen Chu
  • Methods of increasing the production of cobalamins using cob gene expression
    Patent number: 6656709
    Abstract: Novel polypeptides involved in the biosynthesis of cobalamines and/or cobamides, in particular coenzyme B12, genetic material responsible for expressing these polypeptides, and a method for preparing them, are described. A method for amplifying the production of cobalamines, and particularly coenzyme B12, using recombinant DNA techniques, are also described.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: December 2, 2003
    Assignee: Rhone-Poulenc Biochimie, et al.
    Inventors: Francis Blanche, Beatrice Cameron, Joel Crouzet, Laurent Debussche, Sophie Levy Schil, Denis Thibaut
  • Recombinant minimal catalytic vanadium haloperoxidases and their uses
    Patent number: 6656715
    Abstract: The present invention provides new recombinantly produced vanadium haloperoxidases. The enzymes are useful in a number of industrial applications.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: December 2, 2003
    Assignee: The Regents of the University of California
    Inventor: Valerie Vreeland
  • Polynucleotide portions of the biotin operon from B. subtilis for use in enhanced fermentation
    Patent number: 6656721
    Abstract: The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which causes auxotrophic growth of the microorganism wherein the auxotrophy within the microorganism does not compromise the ability of the microorganism to produce the fermentation product. The medium is then supplied in excess with all substrates required for production of the fermentation product and in growth limiting amounts with a substrate complementing the auxotrophy. Host cells, vectors, and polynucleotide sequences used in the process are also provided. The polynucleotide sequences of the present invention include sequences derived from the biotin operon of B. subtilis, and in particular the bioFDB gene cassette.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: December 2, 2003
    Assignee: Roche Vitamins, Inc.
    Inventors: Hans-Peter Hohmann, Nigel John Mouncey, Heinrich Winfred Schlieker, Jeffrey W. Stebbins
  • Polypeptide fragments of human PAK5 protein kinase
    Patent number: 6656716
    Abstract: The present invention related to the novel human kinase polypeptides STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, ZC1, ZC2, ZC3, ZC4, KHS2, SULU1, SULU2, SULU3, GEK2, PAK4, and PAK5, nucleotide sequences encoding the novel kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: December 2, 2003
    Assignee: Sugen, Inc.
    Inventors: Gregory Plowman, Ricardo Martinez, David Whyte
  • Protegrins
    Patent number: 6653442
    Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: November 25, 2003
    Assignee: IntraBiotics Pharmaceuticals, Inc.
    Inventors: Conway C. Chang, Chee L. Gu, Jie Chen, Deborah A. Steinberg, Robert I. Lehrer, Sylvia S. L. Harwig, Vladimir N. Kokryakov
  • Methods of making polyhydroxyalkanoate using biosynthesis genes from alcaligenes latus
    Patent number: 6649382
    Abstract: There are described methods for making polyhydroxyalkanoate and its copolymers, by culturing a host cell transformed with a vector comprising a polyhydroxyalkanoate biosynthesis-related DNA fragment isolated from Alcaligenes latus. The DNA fragment comprises genes that encode for polyhydroxyalkanoate synthase, &bgr;-ketothiolase, and acetoacetyl-CoA reductase.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: November 18, 2003
    Assignee: LG Chemical Ltd.
    Inventors: Jong-il Choi, Sang Yup Lee, Kyuboem Han
  • Cells with altered betaine catabolism and their use in producing metabolites or enzymes
    Patent number: RE38331
    Abstract: Cells with an alteration at least in the gene involved in betaine catabolism, their preparation and their use, in particular for producing metabolites and/or enzymes, are disclosed.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: November 25, 2003
    Assignee: Rhone-Poulenc Biochimie
    Inventors: Beatrice Cameron, Joel Crouzet