Abstract: A medical appliance for use in medical procedures to controllably advance a medical device through a sheath. The medical appliance features pneumatic action and connecting structures adapted to couple the appliance to a variety of types of catheters, tools, and instruments.

Abstract: The invention relates to skin tape stripping methods to identify a subject at risk of having atopic dermatitis, or a subject having atopic dermatitis who is at risk of developing a food allergy, or a subject at risk of developing a food allergy in the absence of the subject having atopic dermatitis.

Abstract: Apparatus, methods, and systems for detecting alcohol concentrations of an individual, and in particular in vivo alcohol concentrations of an individual. Alcohol sensing compositions include at least one alcohol-responsive active area comprising a concerted enzyme system having at least a first enzyme and second enzyme capable of acting in concert to facilitate the detection of alcohol. At least one of the enzymes in the concerted enzyme system is a ketoreductase.

Abstract: An apparatus and method for examining an organism surface includes a pliable member including a contact layer, a plurality of channels, and a reaction layer, wherein the plurality of channels are disposed between the contact layer and the reaction layer; each of the channels having a size in the range of micrometers and formed of biocompatibility materials, and the contact layer including a plurality of spherical projections having a size in the range of micrometers and formed of biocompatible materials, and the reaction layer including examining molecules and a reaction unit.

Abstract: Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

Abstract: Handheld steering devices for use with intravascular devices and associated systems and methods are disclosed. In some instances, the handheld steering device includes a housing sized and shaped for grasping by a hand of a user; a steering controller coupled to the housing; a processor in communication with the steering controller, the processor configured to translate inputs from the steering controller into actuation signals based on a code architecture that includes a script for at least one of a return home function, a return to stored position function, a store current position function, or an automated mapping function; and an actuator positioned within the housing and configured to interface with the intravascular device based on the actuation signals to the steer the intravascular device. Associated systems and methods are also disclosed.

Abstract: A method for evaluating a gastrointestinal tract may include receiving an electrical signal that includes data pertaining to motility in the gastrointestinal tract of a patient and analyzing one or more characteristics of the electrical signal relative to one or more respective thresholds indicative of an occurrence or an imminence of a condition of the gastrointestinal tract.

Abstract: The invention refers to a method of determining an indicator that is representative for a patient's volume responsiveness, comprising the following steps: (i) measuring a sequence of pulse signals of a patient; (ii) determining an envelope(signal)-curve based on the sequence of measured pulse signals; (iii) determining a fit(envelope(signal))-function based on the previously determined envelope(signal)-curve, the fit(envelope(signal))-function representing an idealised curve progression of the envelope(signal)-curve without comprising pulse variations caused by ventilation or respiration induced heart-lung interaction; (iv) determining respiratory pulse variation signals corresponding to the pulse variations caused by ventilation or respiration induced heart-lung interaction; (v) determining an envelope(respiration)-curve based on the previously determined respiratory pulse variation signals; (vi) determining a fit(envelope(respiration))-function based on the previously determined envelope(respiration)-curve,

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract: Provided herein are devices, systems, and methods for assessing, treating, and for developing new treatments for pulmonary arterial hypertension (PAH) using pulmonary artery pressure (PAP) values and/or cardiac output (CO) estimates.

Abstract: An apparatus for estimating a biological substance in a user using a unit spectrum for the biological substance acquired using a biological tissue simulation solution is provided. The apparatus may include a spectrometer configured to emit a light to a skin of a user, detect the light returned from the skin, and measure a skin spectrum of the user from the detected light and a processor configured to estimate a biological substance in the user based on the measured skin spectrum and a unit spectrum acquired using a biological tissue simulation solution.

Abstract: A wearable breath analysis device is disclosed that may be worn, for example, around the neck or wrist of a user. The wearable device may be a stand-along device (in which case it may include a display that provides a user interface), or may operate in conjunction with a smartphone or other command device. The wearable device may include auditory and/or vibratory notice and communications features or capabilities, for example, such as a reminder or notice to conduct a breath analyte measurement, instructions to the user in the course of conducting the measurement, and notice of the breath analyte measurement results. The auditory or vibratory notice may be provided at the wearable, and/or at the command device where a command device is used. Related methods also are provided.

Abstract: A breath analysis device into which a user exhales a breath sample is capable of venting an initial portion of the breath sample from the device, and routing a second portion of the breath sample into a disposable cartridge containing an interactant. The device may include a sensor, such as a pressure sensor, for detecting the initiation of exhalation, and may include a controller that switches a valve during the exhalation process to route a desired portion of the breath sample into the cartridge. After the exhalation process, an LED/photodiode arrangement, or another type of optical sensor, may be used to measure a color change produced by a chemical reaction in the cartridge, to thereby measure a concentration of a ketone or other analyte in the breath sample.

Abstract: Provided is a pain estimating device with which it is possible to estimate objectively and accurately pain being experienced by a subject. A pain estimating device 110 estimates the magnitude of pain being experienced by a subject, on the basis of brainwaves of the subject, and is provided with: a measurement unit 111 which acquires a plurality of items of brainwave data or analysis data thereof by measuring brainwaves from the subject a plurality of times; and an estimation unit 112 which estimates the relative magnitude of the pain being experienced when the brainwave measurements were conducted a plurality of times, from the plurality of items of brainwave data or the analysis data thereof (for example the amplitude), on the basis of the linearity of a relationship between the brainwave data or the analysis data thereof (for example the amplitude) and the pain.

Abstract: According to some embodiments of the present disclosure, a device and method for determining an allowable amount of blood glucose (bG) of a patient is disclosed. The method further includes receiving a current bG measurement, determining a target bG value, and determining a correction delta bG value based on one or more advice history records. The method includes determining a correction meal rise value and determining a maximum allowed bG value based on the target bG value, the correction delta bG value, and the correction meal rise value. The method includes setting the allowable amount of bG value equal to the maximum allowed bG value when the current bG measurement is greater than the target bG value and determining the allowable amount of bG value using the target bG value and the correction delta bG value when the current bG measurement is less than the target bG value.

Abstract: A method and system for neuro-feedback training are disclosed. According to certain embodiments, the method may include receiving, by a processor via a communication network, a brainwave signal measured by at least one sensor attached to a user. The method may also include determining, by the processor, a frequency distribution of the brainwave signal. The method may also include determining, by the processor, a reward in a video game when at least one first value indicative of an amount of the brainwave signal within a first frequency band meets a first criterion. The method may further include providing, to the user, a first feedback signal indicative of the reward.

Abstract: A volatile organic compound detection device includes a collector comprising: a collector material configured to collect volatile organic compounds given off from a patient's skin; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a flow channel configured to receive the volatile organic compounds desorbed by the heater; and a fastener configured to secure the collector to the patient's skin.

Abstract: A sheath for producing a fully sealed access to the interior of a vessel of an animal or human body comprises a base sheath having a tubular body defining a pass-through channel. The base sheath is adapted to be inserted into the vessel through a vessel aperture. The sheath further comprises an expansion device which is adapted to cooperate with the base sheath such that the outer diameter of the sheath increases in the region of the vessel aperture with the sheath in a stationary position in the vessel and upon actuation of the expansion device.

Abstract: A method and transceiver for calibrating an analyte sensor using one or more reference measurements. In some embodiments, the method may include receiving a first reference analyte measurement (RM1) and determining whether the RM1 is unexpected. In some embodiments, the method may include, if the RM1 was determined to be unexpected, receiving a second reference analyte measurement (RM2). In some embodiments, the method may include determining whether one or more of the RM1 and the RM2 are acceptable as calibration points. In some embodiments, the method may include, if one or more of the RM1 and the RM2 are determined to be acceptable as calibration points, accepting one or more of the RM1 and the RM2 as calibration points. In some embodiments, the method may include calibrating the analyte sensor using at least one or more of the RM1 and the RM2 as calibration points.

Abstract: A wearable body fat combustion measurement device includes a housing including a first chamber with an opening, a fixing means attached to the housing and configured to bring the housing into close contact with a user's skin in a state in which the opening of the first chamber faces the user's skin, a measurement sensor disposed inside the first chamber and configured to generate an electrical signal according to an amount of acetone contained in a gas evaporated from sweat discharged from the user's skin and introduced into the first chamber through the opening, a reference sensor disposed outside the first chamber and configured to generate an electrical signal according to a concentration of a gas component contained in an ambient air and detectable by the measurement sensor, and a signal processor configured to process the electrical signals received from the measurement sensor and the reference sensor.