Abstract: According to one embodiment of the present invention, a method of determining respiratory parameters comprises determining a ratio of pressure changes to flow changes induced in the breathing of a patient by an airflow perturbation device at each of a plurality of perturbation frequencies to form a dataset. Resistance, compliance, and inertance parameters of a model of a respiratory system are determined by comparing a predicted frequency dependence of the model to the dataset. Embodiments of the present invention further include a system and computer program product for determining respiratory parameters in substantially the same manners described above.

Abstract: A system for displaying a plurality of hemostatic indexes is disclosed. The system includes a communication receiver configured to receive the hemostatic indexes and a graphical user interface (GUI) connected to the communication receiver and configured to simultaneously display the hemostatic indexes. The hemostatic indexes are derived from a plurality of independent measurements, such as the mechanical measurements determined using the sonorheometry systems and processes.

Abstract: A method for weight and/or fitness management using a metabolic analyzer that measures metabolic data including oxygen and carbon dioxide. The metabolic analyzer includes integrated collection-detection sensors with for high efficiency and collection, high specificity and simultaneous detection of at least two metabolic signatures, including at least oxygen and carbon dioxide, in breath via a porous membrane with high density of sensing binding sites, where the porous membrane includes sensing materials such that the sensing binding sites are specific to the metabolic signatures, and change colors upon interactions with the metabolic signatures. Weight of the subject is measured using a weight measurement device and a recommendation for food intake and/or physical activity is based on at least the readings of the metabolic analyzer and weight of the subject.

Abstract: A method is provided for determining blood pressure for a subject using a sphygmomanometer. The method includes: measuring an oscillometric cuff pressure waveform of the subject using the sphygmomanometer; representing the measured waveform with a physical model accounting for mechanics of the cuff, an artery and coupling between the cuff and the artery; determining the model unknowns from the measured waveform; and determining blood pressure for the subject using the determined model.

Abstract: An airway adaptor includes: an airway case; and an expired gas guiding portion which is connected to the airway case to introduce a respiratory gas to the airway case. The airway case includes: a first respiratory gas flow path in which the respiratory gas flows in a first direction; and a second respiratory gas flow path in which the respiratory gas flows in a second direction opposite to the first direction.

Abstract: A catheter is disclosed for providing a pressure measurement at a vascular lesion. The catheter includes a tubular component having dual lumens along at least a segment thereof in which a first lumen acts as a pressure inlet and a second lumen allows the catheter to be tracked over a guidewire. A plurality of openings are located along a distal segment of the tubular component that permit blood flow into the first lumen when disposed in vivo. A pressure sensor is located within a handle component of the catheter or within the tubular component to be in fluid communication with a proximal end of the first lumen. When the catheter is positioned at the vascular lesion, the first lumen fills with blood via the plurality of openings such that the pressure sensor is able to sense a pressure of the blood at a distal end of the catheter.

Abstract: A variety of embodiments of an at least partially flexible actuator are provided. The actuator includes a phase change material contained within an at least partially flexible enclosure of the actuator. Application of heat, using a heater of the actuator, to the phase change material causes the phase change material to boil, increasing the volume of the actuator and/or increasing a pressure within the actuator. As a result, the actuator can be used to apply a force to objects in an environment of interest. The actuator could be incorporated into a wearable blood pressure cuff and used to apply pressure to a body part of a wearer in order to detect a blood pressure of the wearer. In other examples, the actuator could be incorporated into a wearable device and used to secure a sensor or other elements of the device against skin of a wearer.

Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The flexible substrate is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body. The device includes a flexible display configured to provide indications to a user, e.g., indications of sensor readings, medical alerts, or operational states of the device. The display could be operated on a very low power budget, e.g., the display could be operated intermittently. In some examples, the display could include an e-paper display or similar low power display elements. In some examples, elements of the display, e.g., electrodes of a multi-segment display, could be formed on the flexible substrate such that additional elements of the display, e.g., a layer of display medium and a layer of transparent conductor, could be adhered or otherwise attached to the formed elements.

Abstract: A measurement device includes a detection device to detect a pulse wave signal at a first measurement location in a vascular pathway from the heart of a measurement subject to an area where an arterial aneurysm is predicted to occur and a pulse wave signal at a second measurement location in a vascular pathway from the heart of the measurement subject to an area that is different from the area where an arterial aneurysm is predicted to occur, a comparison device to calculate a comparison result by comparing frequency characteristics between the pulse wave signals, and a determination device to determine at least one of the presence/absence and size of an arterial aneurysm based on a predetermined characteristic amount for a frequency contained in the comparison result.

Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

Abstract: An apparatus for the collection of samples of exhaled air during normal respiration, comprising a flow generator, an orally insertable exhalation air receiver, and a device for isolating the nasal airways, wherein the apparatus further comprises: a sensor for detecting a change in a parameter representing the change from inhalation to exhalation and to transmit said change as a signal; a control unit adapted to receive said signal and to control said device for isolating the nasal airways; wherein the flow generator is connected to or integrated with the exhalation air receiver.

Abstract: A sensor module is disclosed herein. The sensor module includes a main housing defining an analysis zone within the housing. The sensor module also includes a skin piercing member mounted within the main housing. The skin piercing member is movable relative to the main housing between a retracted position and an extended position. The main housing of the sensor module defines a fluid sample flow passage that extends from a sampling end of the main housing to the analysis zone. The fluid sample flow passage includes a funnel structure through which the skin piecing member extends when in the extended position. The fluid sample flow passage also includes capillary flow enhancing slots that extend outwardly from opposite sides of the funnel structure.

Abstract: A patient monitoring system includes an inflatable cuff, a gas reservoir containing a compressed gas, and a sensor. When the inflatable cuff is coupled to a wearer, the gas reservoir supplies gas to the inflatable cuff to inflate the inflatable cuff via gas pathways. As the inflatable cuff inflates, a patient monitor can receive blood pressure data from the sensor and use the blood pressure data to determine the blood pressure of the wearer. The patient monitor can also receive blood pressure data during deflation of the inflatable cuff to determine the blood pressure of the wearer.

Abstract: Technologies are generally described to monitor a sweat rate of an area of a skin. A hydration status of a human or non-human entity is monitored based on the sweat rate. The sweat rate is monitored when the sweat rate monitor is detected as sealed against the surface of the skin. The sweat rate monitor is attached to the surface of the skin with an adhesive, or a tape among other schemes to hold the sweat rate monitor in place during a measurement. The sweat rate monitor includes a container to capture an initial amount of sweat that comes out of the surface of the skin. When, the container is detected as filled with the initial amount of sweat, a pump of the sweat rate monitor is actuated to compress the container. The container is compressed to force a volume of the initial amount of sweat in the container out of an ejection port of the sweat rate monitor.

Abstract: A biopsy needle surrounded by a peel away sheath chemically impregnated with a blood detection composition enabling a user (e.g., a surgeon) to accurately and timely determine the existence of a blood pooling or hematoma when passing an implantable (e.g., deep brain stimulation probes) or non-implantable (e.g., biopsy needle) device into a region of the subject's body (e.g., a brain) to gather tissue for further analysis. A biopsy needle may be provided wherein the needle is tightly surrounded by a peel-away sheath that is chemically impregnated with a blood detection composition. The surgeon may insert the biopsy needle into the subject and peel away the chemically impregnated sheath in order to assess whether or not a blood pooling or hematoma exists, and act immediately to address the blood pooling or hematoma.

Abstract: A urinary funnel has proximal and distal openings and is preferably made from a resilient web scored to define two side panels foldable at a lower fold line that attach mutually together at a top flap. The funnel is collapsible so as to be carried in a wallet or purse. At least one biological indicator is fixed with the inner surface of the funnel structure proximate the distal opening for detecting the use of illicit drugs, pregnancy, or other biological conditions. The web may further includes a transverse slot proximate the lower fold line that is adapted to receive a biological indicator test strip therethrough. The biological indicator is applied to the biological indicator test strip that is in turn positioned through the transverse slot to rest against the inner surface of the funnel structure within the stream of urine flowing from the proximal opening to the distal opening.

Abstract: An apparatus for the collection of samples of exhaled air during normal respiration, comprising a flow generator, an orally insertable exhalation air receiver, and a device for isolating the nasal airways, wherein the apparatus further comprises: a sensor for detecting a change in a parameter representing the change from inhalation to exhalation and to transmit said change as a signal; a control unit adapted to receive said signal and to control said device for isolating the nasal airways; wherein the flow generator is connected to or integrated with the exhalation air receiver.

Abstract: A low dead space liquid trap includes: a tube, having an inlet, an outlet, and an aperture disposed between the inlet and the outlet at a bottom of the tube, wherein the tube defines a channel extending in a first direction between the inlet and the outlet, the channel having a cross section perpendicular to the first direction; a reservoir disposed beneath the aperture of the tube; and a gas permeable membrane extending across the channel at an angle greater than zero with respect to the cross section of the channel.

Abstract: A low back pressure mouthpiece for accurate detection of exhaled nitric oxide (NO) includes a conduit for receiving the exhaled breath from the subject. An oxidizing filter for sample conditioning, wherein the conduit and oxidizing filter operate to produce a back pressure of less than 4 cm H2O; and a device for measuring the level of one or more components of the received exhaled breath.

Abstract: An intravascular sensor assembly including a flexible elongate member having a longitudinal axis (LA) is provided. The sensor assembly includes a first engagement feature proximal to a distal end of the flexible elongate member; a core member disposed inside a lumen of the flexible elongate member, the core member configured to translate within the flexible elongate member along the LA proximal to the first engagement feature; and a component holding a sensor circuit, the component fixedly secured to a distal end of the core member such that the mounting structure translates along the LA of the flexible elongate member with the core member. A system and a method for performing measurements using a sensor as above are also provided.