Patents Examined by Qian J Li
  • Targeted integration into chromosomes using retroviral vectors
    Patent number: 6656727
    Abstract: The present invention relates to a retroviral vector encoding heterologous genes particularly for gene therapy of genetic defects or viral infections.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: December 2, 2003
    Assignee: Institut Fur Virologie
    Inventors: Walter H. Günzburg, Brian Salmons, Sabine Goller, Dieter Klein
  • Gene whose expression promotes differentiation of myeloid progenitor cells into neutrophils and/or monocytes/macrophages
    Patent number: 6605710
    Abstract: The present invention provides a human gene sequence that encodes the CDDP-1 polypeptide, which is involved in cell differentiation, in particular differentiation of undifferentiated progenitor cells into neutrophils, monocytes/macrophages, mast cells, and/or erythroid cells. Assays for detecting CDDP-1 expression, vectors that express CDDP-1, methods for using CDDP-1 to induce or promote cell differentiation, and transgenic animals deficient in one or both CDDP-1 alleles are described.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: August 12, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Richard C. Schwartz, Qiang Tian
  • Alphavirus vectors for paramyxovirus vaccines
    Patent number: 6475780
    Abstract: A DNA vector comprises a first DNA sequence which is complementary to at least part of an alphavirus RNA genome and having the complement of complete alphavirus DNA genome replication regions, and a second DNA sequence encoding a paramyxovirus protein, particularly a respiratory syncytial virus fusion (RSV F) protein or a RSV F protein fragment that generates antibodies that specifically react with RSV F protein, the first and second DNA sequences being under the transcriptional control of a promoter, preferably a cytomegalovirus promoter, which may include Intron A. Such vectors also contain a further nucleotide sequence located between the promoter sequence and the alphavirus sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 5, 2002
    Assignee: Aventis Pasteur Limited
    Inventors: Mark Parrington, Xiaomao Li, Michel H. Klein
  • Method for penile augmentation with autogenous dermal cell culture
    Patent number: 6465000
    Abstract: The present invention relates to a penile augmentation method comprising culturing autodermal cells in a laboratory and inserting this into penis by using scaffold. This method has advantage of operation convenience, and causes no foreign body sensation after operation and no side effect.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: October 15, 2002
    Inventor: Jeoung Yong Kim
  • Use of &bgr;-catenin in the expansion of stem and progenitor cells
    Patent number: 6465249
    Abstract: Mammalian progenitor or stem cells are expanded in vitro by increasing the levels of &bgr;-catenin in the cell. The expanded cells substantially maintain their original phenotype including the ability to give rise to multiple types of differentiated cells. The intracellular levels of &bgr;-catenin may be manipulated by providing exogenous &bgr;-catenin protein to the cell, or by introduction into the cell of a genetic construct encoding &bgr;-catenin. The &bgr;-catenin may be a wild-type or stabilized mutant form of the protein. Preferably the long term cell culture medium substantially lacks stromal cells and cytokines.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: October 15, 2002
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tannishtha Reya, Roeland Nusse, Irving L. Weissman