Abstract: Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin D are disclosed. The 25-hydroxyvitamin D may be administered with an agent that increases the risk of hypocalcemia, such as cinacalcet or a salt thereof, and/or an anticancer agent. The adjunctive therapy is effective to treat and prevent iatrogenic hypocalcemia and/or secondary hyperparathyroidism, as well as delay cancer progression and the time to a post-treatment skeletal related event.

Abstract: The present invention discloses a method for controlling surface-inhabiting pests in an aquatic system, in particular cyanobacteria and harmful algal blooms (HABs), comprising spreading on the surface of the aquatic system a buoyant composition comprising a water disinfectant, preferably an oxidizing compound, and a floating agent. The invention further relates to compositions and methods for their preparation and use.

Abstract: Various aspects of the present disclosure provide compositions, coatings and implantable devices including a drug and an excipient. In certain embodiments the excipient and the drug are present at a weight ratio of between 10 to 1 and 1 to 10 drug to excipient. In certain other embodiments, the excipient and the drug form particles in which the drug is encapsulated by the excipient. Other aspects of the disclosure provide methods of manufacturing and using such compositions, coatings and implantable devices.

Abstract: The invention relates to water-free compositions, having: at least one oil, and a combination of thickeners, including: a) at least one silicone elastomer, b) at least one straight-chained or branched, saturated or unsaturated alcohol having more than 18 carbon atoms, and c) at least one clay mineral mixture modified with quaternary ammonium compounds. The water-free compositions are suitable in particular as soft solid preparations for use on the human skin. In particular, the compositions are suitable as a soft solid antiperspirant composition.

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.

Abstract: A prophylactic cream, ointment or deodorant for the prevention of the formation of yeast infections.

Abstract: In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in need thereof, wherein In certain embodiments, the AMPK activator is metformin or salt thereof. In certain embodiments, the subject has been diagnosed with nephrogenic diabetes insipidus.

Abstract: The present invention relates to solid pharmaceutical dosage forms for oral administration comprising sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate (active ingredient (I)), characterized in that the active ingredient (I) is released, and also methods for the preparation thereof, use thereof as medicaments, and also use thereof for prophylaxis, secondary prophylaxis or treatment of disorders, particularly cardiovascular disorders, heart failure, anemia, chronic renal disorders and renal insufficiency.

Abstract: A packaged rodenticidal bait comprises a soft bait composition enrobed in a perforated thermoplastic film, wherein the soft bait composition comprises a blend of at least one edible fat, at least one particulate food component and at least one rodenticidally-active substance. Preferably, the thermoplastic film comprises one or more polyolefins. The perforated film used in the manufacture of the packaged bait according to the invention does not absorb fat, unlike conventionally-used paper sachets. The packaged bait composition of the invention is palatable to rodents such that rodents may take a lethal dose of a rodenticide from the bait in a single sitting.

Abstract: The invention provides a pharmaceutical composition for preventing or treating mucositis, for example oral mucositis (e.g., oral ulceration) and gastrointestinal mucositis, comprising a monoacetyldiacylglycerol compound, especially PLAG, and a method of preventing or treating mucositis using the same.

Abstract: A topical drug delivery patch (1) comprising a drug delivery layer (3) including microspheres (2) encapsulating a drug, said microspheres being carried in a hydro gel. The drug delivery layer has a support layer (5) which is attached to a first face of the drug deliver layer and a releasable protective layer (4) attached to a second face of the drug delivery layer. The releasable protective layer can be peeled away do the patch can be applied to the skin to release drugs in the microspheres. The patch is particularly useful for treating skin conditions such as psoriasis and eczema.

Abstract: The invention provides novel liquid compositions comprising acryloyldimethyltaurate salt/VP copolymer, as well as wet wipe products including such compositions.

Abstract: The invention relates to an antimicrobial particle and to a composition for use in personal or home care products comprising the same. The invention also relates to a process for preparing the antimicrobial particle. The antimicrobial particle comprises thymol and terpineol incorporated in a cage-forming inorganic silicate or aluminosilicate particle which is coated with a coating material selected from a water soluble alkali or alkaline earth metal salt.

Abstract: The present invention relates to oil-in-water emulsion-forming compositions having reduced whitening effect when applied on wet substrates. The oil-in-water emulsion compositions are suitable for use in personal care products, textile treatments, polishing products, gloss enhancements and water resistance treatments.

Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.

Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

Abstract: The present application relates to antiperspirant compositions comprising nitrogen-based and/or oxygen based perfume raw materials, and methods for making and using the antiperspirant compositions.

Abstract: A solution that is stable at 5° C. to 30° C. for at least 24 hours, comprising: (a) water, (b) montelukast sodium; (c) a carrier material for a fast disintegrating dosage form; and (d) a component selected from a strong base, a bicarbonate salt and mixtures thereof. The solution comprising montelukast sodium is stable under conditions that are typically encountered during certain phases of the manufacturing process of fast disintegrating dosage form that contain the montelukast sodium. The solution can be used to form fast disintegrating dosage form tablets. A method of preparing a fast disintegrating dosage form tablet including preparing such solution, and forming a tablet, and a fast disintegrating dosage form that is prepared from the montelukast sodium solution are also described.

Abstract: The present invention provides improved solutions and related methods for effecting enhanced penetration of wood preservatives through the synergistic action of an amine oxide employed in combination with an alkoxylated oil and a buffering agent. Preferred materials and quantities are recited. The system of the present invention may be employed with artificially stiffened wood.

Abstract: This disclosure provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units, wherein said capsule dosage form is bioequivalent to the marketed Toprol-XL® tablet. The extended-release capsule dosage form comprising coated discrete units can be sprinkled onto food to ease administration to patients who have difficulty swallowing tablets or capsules.