Abstract: A Housing for an infusion pump cartridge adapted to enclose a glass vessel having an open proximal end closed by a slidable piston and a distal end provided with a neck is provided. The housing is made of plastic. The proximal end is provided with a pair of bayonet fitting formations integrally formed on the housing and adapted to enable the cartridge to be fastened to an infusion pump and with connection means adapted to be arranged at the distal end of the vessel for connection to an infusion set. The housing consists of a cylindrical base part, which is provided with an inner flange for abutment of the vessel and on which the fitting formations are formed, and a neck part that can be fastened to the base part by means of snap fitting formations for retaining the glass vessel between the base part and the neck part.

Abstract: Systems and devices for monitoring, detecting, and removing fluid build-up found at various regions along a tracheal tube of an intubated patient. The fluid management system includes pressure and flow sensors for detecting whether there is fluid at the various regions along the tracheal tube, and a means for drawing out the fluid into collection jars. The system also includes lavage features that is able to rinse different the various regions along a tracheal tube. Also disclosed are respiration insertion devices that either couple to existing tracheal tubes or incorporate tracheal tubing, where the respiration insertion body has channels and ports that contact various regions along the tracheal tube. The combination of the fluid management system and the respiration insertion devices effectively monitor and remove fluid at various locations along a tracheal tube of an intubated patient.

Abstract: A system and method for patient-adaptive hemodynamic management is described. One embodiment includes a system for hemodynamic management including transfusion, volume resuscitation with intravenous fluids, and medications, utilizing monitored hemodynamic parameters including the described dynamic predictors of fluid responsiveness, and including an intelligent algorithm capable of adaptation of the function of the device to specific patients.

Abstract: A device and method for controlling operation of an ambulatory infusion device drive. The drive may have a spindle drive with a stepper motor, a drive member operatively coupled to a rotary encoder, and a driver controller that executes several steps, including actuating the stepper motor to execute a requested number of steps in a current drive control sequence, receiving a drive member position that indicates an actual position of a drive member following the actuation, computing an executed steps number from the drive member position, computing a missed steps number for the current drive control sequence, which is the difference between the requested number of steps and the executed steps number, determining when the ambulatory infusion device drive is blocked based on a statistical evaluation of a time-distribution of the missed steps number over a history of drive control sequences, and generating a blockage alarm signal.

Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: A flushing system for a catheter, in particular for a catheter of a catheter pump, comprising a supply line having a pump section, a discharge line having a pump section and a pump, wherein the diameter of the pump section of the discharge line is smaller than the diameter of the pump section of the supply conduit, the pump interacts with the pump section of the supply line for supplying flushing fluid to the catheter, and the pump interacts with the pump section of the discharge line for discharging flushing fluid from the catheter.

Abstract: A packaging assembly comprises a case configured to contain at least one injection device for delivering a medicament; a cooling unit configured to lower an internal temperature of the case; a processing arrangement; a device sensor configured to detect at least one injection device contained within the case, and to receive device storage information from the at least one detected injection device; and a data storage device. The processing arrangement is configured to record an injection history on the data storage device. The processor arrangement is configured to control the cooling unit to set an internal temperature of the case according to the received device storage information.

Abstract: An electrically energized medical instrument uses one or more drive cables to both actuate mechanical components of a wrist mechanism or an effector and to electrically energize the effector. Electrical isolation can be achieved using an insulating main tube through which drive cables extend from a backend mechanism to the effector, an insulating end cover that leaves only the desired portions of the effector exposed, and one or more seals to prevent electrically conductive liquid from entering the main tube. Component count and cost may be further reduced using a pair of pulleys that are shared by four drive cables.

Abstract: The present disclosure relates to a medicament delivery device comprising a housing, a reservoir for medicament disposed in the housing and a dispensing member. The dispensing member is moveable relative to the housing from a first position to a second position to dispense medicament from the reservoir when the reservoir contains medicament. The medicament delivery device further comprises first and second biasing members. The first biasing member is configured to urge the dispensing member from the first position to an intermediate position. The second biasing member is configured to urge the dispensing member from the intermediate position to the second position.

Abstract: An expandable dilation member may include a proximally-tapered portion to dilate a stricture. The dilation member may be distally advanced in an unexpanded state over a wire guide through the stricture. The dilation member may then be configured in an expanded state, where the dilation member has a longitudinal profile that includes the proximally-tapered portion. A handle assembly proximally pulls the dilation member in the expanded state. In response, the proximally-tapered portion engages with and biases the stricture. When biasing the stricture, the proximally-tapered portion exerts a plurality of different types of forces, including a shearing force, a radial force, and in some procedures, a torsional force. In some embodiments, the proximally-tapered portion has a continuous taper from a smallest diameter to a largest diameter. In other embodiments, the proximally-tapered portion has at least one constant-diameter portion longitudinally disposed in between the smallest diameter and the largest diameter.

Abstract: A medical device system. The system includes a first medical device, a first remote interface, and a second remote interface in communication with the first remote interface and the first medical device, wherein the first medical device sends a command to the first medical device through the second remote interface, and wherein when the second remote interface receives the command, the command must be confirmed by the second remote interface before the command is send by the second remote interface to the first medical device.

Abstract: Break-away connectors are disclosed. The break-away connectors may be configured to be coupled in at least two configurations, for example, a high force configuration and a low force configuration. The break-away connectors may also be incrementally adjustable between the high force configuration and the low force configuration. The break-away connectors may be coupled to a first medical device and a second medical device. Methods of using and/or coupling the break-away connectors are also disclosed.

Abstract: A ventilation system including a ventilator having a cooling fan configured reduce an internal temperature of the ventilator. The ventilator also includes a controller configured to control operation of the ventilator. A detector is configured to generate a detection signal when the ventilator is connected to a cold passover humidification (CPH) device. In response to the detection signal, the ventilator reduces or eliminates operation of the cooling fan in comparison to a default mode of operation. A method of providing increasing a temperature of a flow of air to a CPH device is also included.

Abstract: A catheter includes a tubular inner layer, a reinforcement body disposed around the outer periphery of the inner layer, a protective layer covering the outer periphery of an end of the reinforcement body, and an outer layer covering at least the outer periphery of the protective layer. The protective layer covers the outer periphery of at least one end of reinforcement body, and the end of the reinforcement body covered with the protective layer is buried deeper in a side of the inner layer relative to a portion of the reinforcement body not covered with protective layer. The reinforcement body is prevented from lifting away from the inner layer when the catheter is bent even without increasing the outer diameter of the reinforcement body.

Abstract: The present disclosure provides medical devices, particularly medical grade needles with removable tips, as well as methods of needle tip installation and removal, and devices therefor. Needle tip installation and removal devices may include needle tip installation and removal tools and kits, including hand held and manipulated tools that facilitate the installation and removal of needle tips, particularly on vascular access port needles. Such installation and removal devices may provide more expedient hook up of the access port for the therapy. Also, the installation and removal of the needle tips may be conducted in a more sterile manner.

Abstract: The invention concerns an injector device (100), comprising access means (110, 115) configured to selectively allow and prevent a cartridge (120) storing a pharmaceutical product (122) from being removed from the injector device (100), a self-test unit (130) configured to cause a self-test of at least one of an electronic component and an electronic assembly of the injector device (100), and a control unit (140) configured to control the access means (110, 115) to allow the cartridge (120) to be removed from the injector device (100) in case the self-test has failed.

Abstract: A fluid delivery device includes: a fluid-filled cartridge comprising an outlet; a syringe comprising a substantially cylindrical syringe barrel having an open end and a fluid dispensing end; and a plunger rod configured to be received within the open end of the syringe barrel. The plunger rod comprises: a first end having a sealing member provided in sealing engagement with an inner wall of the syringe barrel such that a first syringe chamber is provided between the first end of the plunger rod and the fluid dispensing end of the syringe barrel; a second end extending out of the open end of the syringe barrel and having a cartridge-receiving chamber having a connection mechanism positioned therein for connecting the outlet of the cartridge thereto. The plunger rod also includes a fluid channel extending from the connection mechanism to the first end of the plunger rod.

Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver insulin, a processor, and a user interface including a bistable display. A display element of the bistable display is placed in one of two stable orientations upon application of a biasing voltage and stays in the stable orientation when the biasing voltage is removed. The processor includes a display module configured to display a non-blank reversion display screen on the bistable display when no input is received at the user interface after a specified time duration, and to recurrently change the reversion display screen until input is received at the user interface.

Abstract: Biomarkers are collected and used to determine biological propensities of a patient, to determine the efficacy of medical devices, to select and administer therapeutic agents, to select medical devices, to make adjustments to medical devices, and/or to adjust surgical techniques. An apparatus includes a port to draw a biological fluid (e.g., a mist) from a surgical site. The apparatus includes a sensor having a cantilevered beam. The beam includes substances selected to attract certain biomarkers as the fluid is communicated across the beam. The same apparatus or another apparatus is used to administer a therapeutic agent based at least in part on collected biomarker data. The therapeutic agent delivery apparatus may include a device that is also used to create a wound at a surgical site. For instance, a harmonic surgical instrument may be used to both collect biomarkers and administer a therapeutic agent (e.g., gene therapy using sonoporation).

Abstract: Exemplary embodiments provide automatic injection devices, housing components for automatic injection devices and methods for fabricating the same. An exemplary housing of an automatic injection device may be overmolded with one or more gripping surfaces to facilitate gripping and manipulation of the automatic injection device by a user when performing an injection. In an exemplary embodiment, an overmolded left gripping surface may extend along a left side of the housing and an overmolded right gripping surface may extend along a right side of the housing opposite to the left side.