Abstract: The present invention relates to a process for preparing biodegradable microspheres containing physiologically active agents. Particularly, the present invention relates to the process comprised the following steps (1) to prepare a polymer solution containing physiologically active agents wherein a biodegradable polymer is dissolved in a water-soluble organic solvent and physiologically active agents are dissolved or suspended to it; (2) to form a O/O type emulsion by emulsifying the polymer solution into a water soluble alcohol which contains an emulsion stabilizer; and (3) to extract the organic solventS and alcohol by adding the emulsion into a neutral or an alkaline aqueous solution to educe the microspheres. The process of the present invention is effective for producing the microspheres having a uniform size which arm congenital to a living body and has an excellent inclusion efficiency. So, the microspheres prepared by the process of the present invention are used for a drug delivery system.

Abstract: A polymerized hydrogel composition and applicator for hydrating or dehydrating a surface, particularly a dermatological surface, to which it is applied and a method for forming the composition. The composition is comprised of a mixture of two polymerizable materials, a two-part redox catalyst system and a two-part polymerization medium. The percentage by weight of each element in the composition may be varied within stated percentage ranges. The rate at which hydration or dehydration occurs may be controllably altered by varying the percentages of certain of the composition elements. The applicator includes a thermoplastic center section and two reservoir sections each having a reservoir storage area for holding moisture and/or medicaments. The composition is mechanically bonded onto each of the reservoir sections and then hydrated. The applicator is designed for insertion into a human mouth after hydration and is used for treating xerostomia.

Abstract: Pharmaceutical compositions are described that comprise one or more active ingredients selected from the group consisting of anti-infective, anti-inflammatory and mucolytic agents, and particularly to compositions formulated as a solution in a unit dose for aerosol administration to treat chronic sinusitis.

Abstract: In accordance with the present invention, there are provided stabilized total nutrient admixture (TNA) compositions which are useful for the in vivo parenteral delivery of pharmacologically acceptable lipids or fats, as well as methods for the preparation thereof. In particular, the pharmacologically acceptable lipid or fat is contained within a protein walled shell. In a particular embodiment of the invention, a TNA composition using human serum albumin (HSA) as a stabilizer has been prepared as a convenient three-in-one formulation (i.e., containing a fat emulsion, dextrose, and amino acids plus electrolytes). This “three-in-one” formulation can be prepared in liquid form or in dry form (comprising submicron-sized nanoparticles). The dried material is stable, even under long term storage, and is easily reconstituted immediately before use by simply adding sterile water (with or without vitamin supplementation) This serves to rehydrate the powder into a TNA suitable for injection.

Abstract: Condensate of superoxide anion radical (SAR) abolisher exhibiting strong and stable SAR abolishing activity is provided. Hydrogen adsorbent is introduced into a solution obtained by dissolving electrolyte into purified water. The solution containing hydrogen adsorbent is introduced into both cathode and anode chambers separated by a diaphragm. With a cathode immersed in the cathode chamber and with an anode immersed in the anode chamber, electricity is applied between the cathode and the anode to electrolyze the solution. Electrolytic reduced water produced in the cathode chamber is derived, and water included in the electrolytic reduced water is evaporated.

Abstract: The invention provides a pharmaceutical composition for preventing and/or curing digestive disorders such as digestive ulcers, gastritis, etc. The pharmaceutical composition contains, as the active ingredient, an aluminosilicate having silver and zinc ions, and it has an excellent effect for protecting gastric mucous membrane and an excellent effect of promoting the curing of a gastric ulcer.

Abstract: Hair treatment compositions are provided which have conditioning benefits and which contain a fatty acid polyester of a polyol selected from cyclic polyols, sugar derivatives and mixtures thereof, in which at least 50% by weight of the total fatty acid moieties of the polyester are C20 or higher unsaturated fatty acid moieties. Specific examples of suitable fatty acid polyesters are sucrose trierucate, sucrose pentaerucate, sucrose tetraerucate, sucrose trirapeate, sucrose tetrarapeate, and sucrose pentarapeate, and mixtures thereof. The compositions are typically in the form of shampoos or conditioners and give surprisingly improved overall conditioning, in particular hair softness.

Abstract: This invention is directed to an oral solid, rapidly disintegrating, freeze-dried dosage form containing coarse particles of a pharmaceutically active material which are uncoated or coated with a polymer or lipid material. Preferably, the oral dosage form comprises coarse particles having a size in the range of 50 micron to 400 micron. The oral solid rapidly disintegrating dosage form according to the present invention preferably disintegrates in the oral cavity in less than 10 seconds.