Abstract: The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables.

Abstract: Provided is a technique for increasing discriminating ability, preventing human error, and improving efficiency of discrimination in a discrimination operation for extracting a sample satisfying a specific condition from among a plurality of samples. A sample discrimination system according to the present disclosure is provided with a plurality of sample retaining devices for retaining samples, and a sample information query device for querying a sample retaining device that matches predetermined query information from among the plurality of sample retaining devices. The sample information query device has a query information input unit for inputting of predetermined query information, and a query information transmission unit for transmitting predetermined query information to the sample retaining devices.

Abstract: A method for reconstituting a reagent within a reagent pack including one or more wells and at least one of the wells containing a lyophilized reagent comprises the steps of receiving reagent packs into a reagent pack input carousel, transferring one reagent pack with a rotary distributor from the input carousel to a reagent pack storage carousel, retrieving the reagent pack from the storage carousel with the rotary distributor and placing the reagent pack into a reagent pack loading station, and dispensing a reconstitution reagent with an automated pipettor into the well containing the lyophilized reagent to form a reconstituted reagent.

Abstract: Systems and methods applicable, for instance, to pipette robots. A pipette robot can perform one or more operations regarding deck calibration, one or more operations regarding pipette tip/probe calibration, one or more operations regarding pipette tip pick up, and/or one or more operations regarding tip ejection.

Abstract: Systems, and methods that facilitate the performance of an assay of a sample substantially in real-time. Thus, the assay can be performed, and the desired result obtained, much more quickly than allowed by conventional systems and methods.

Abstract: A thermal desorption tube for chromatography and mass spectrometry analysis. The thermal desorption tube includes a sorbent and a plurality of focusing agents loaded at known, relative amounts onto the sorbent. Each focusing agent is a compound that chromatographically elutes within a retention time similar to a retention time of a target analyte and has a mass spectrum similar to a mass spectrum of the target analyte. The thermal desorption tube is configured to be further loaded with a sample having the target analyte.

Abstract: A method of detecting a biological substance in a sample, comprises: illuminate the sample by light; imaging the illuminated sample by Fourier transform hyperspectral imaging; and analyzing the obtained hyperspectral image to detect the biological substance in a sample.

Abstract: A liquid evaluation device including a cartridge with one or more channels formed between two closely spaced substrates is disclosed. The cartridge includes one or more liquid flow structures, each of which can be located in a deposition region for a channel, an entrance region for the channel, and/or an interior region of the channel. Each liquid flow structure is configured to facilitate liquid flow to shape and/or locate the liquid in the channel for measuring a volume of the liquid located in the channel.

Abstract: The automatic analyzer includes a first storage device that stores sample information including a measurement result of a reaction solution for each sample and a second storage device that stores the sample information on at least a part of the samples among the sample information stored in the first storage device, in which when the automatic analyzer reaches a predetermined operation state, the control device performs a backup process of backing up the sample information on the samples satisfying a predetermined backup condition from the first storage device to the second storage device, and deleting the sample information on the backed up samples from the first storage device.

Abstract: A device for the capture and adsorption of blood-borne materials of interest comprising a fluidic cartridge with at least one inlet and at least one outlet; a multidirectional fluidic channel between the at least one inlet and the at least one outlet; said multidirectional fluidic channel comprising at least one inner wall; and a substance coating at least a portion of the at least one inner wall of the multidirectional fluidic channel.

Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

Abstract: An electrical charge storage medium comprises a quantity of first electrically conductive particles contained in a non conductive binder (for example polyurethane). The first electrically conductive particles are magnetite particles. The quantity of magnetite particles includes a distribution of particle sizes between sub-micron and tens of microns, and the magnetite particles have a plurality of planar faces, adjacent planar faces connected at a vertex. The particles each have a plurality of vertices. The magnetite particles are irregular in shape and have a low aspect ratio. Electrical charge storage medium is applied to a non-conductive substrate and contacted by two spaced apart electrodes to sense the change in resistance upon intercation with a volatile organic compound.

Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.

Abstract: To provide a temperature adjustment stage that can efficiently heat a cartridge in accordance with necessity of heating each well. A temperature adjustment stage for heating a cartridge in which a plurality of wells that store a liquid are formed. The cartridge is used in an inspection system that detects an object captured by an immunoreaction, the wells include a labeled antibody well that stores a labeled antibody that labels the object, and there is provided a structure that does not heat the labeled antibody well.

Abstract: A thermal cycler includes: a support block configured to support a reaction vessel; a Peltier element thermally connected to the support block and configured to adjust a temperature of a sample solution stored in the reaction vessel by heating/cooling the support block; a temperature sensor configured to measure a temperature of the support block; and a temperature adjusting unit configured to control a current and a voltage supplied to the Peltier element based on the temperature of the support block measured by the temperature sensor. As the reaction vessel, a reaction vessel including a conical portion which opens at an upper portion and tapers toward a lower portion is used, and the Peltier element is arranged so as to be parallel to a conical generatrix portion of the reaction vessel.

Abstract: Described are chromogenic sensors, methods of use, and kits including sensors. The sensors can have a polymer structure with a waveform cross-section in a programmed state. Upon exposure to a first liquid, the polymer structure in the programmed state changes to polymer structure in an activated state. Methods for measuring the presence of a liquid using the sensor are described, as are kits including the sensors.

Abstract: A reaction processing apparatus includes: a reaction processing vessel; a temperature control system; and a liquid feeding system. The liquid feeding system includes: a pump having a discharge port; a first air channel; a second air channel; a first three-way valve capable of being switched between a state in which a first air communication port communicates with the discharge port and a state in which the first air communication port is opened to the atmospheric pressure; a second three-way valve capable of being switched between a state in which a second air communication port communicates with the discharge port and a state in which the second air communication port is opened to the atmospheric pressure; and a CPU that controls these components.

Abstract: An optical sensor and a method of operating the optical sensor are provided. The optical sensor includes a light source configured to emit a light, and a path adjuster configured to adjust a traveling path of the light to reflect the light at a first time, and allow the light to pass through the path adjuster at a second time. The optical sensor further includes a light receiver configured to receive a reference light among the reflected light, and receive, among the light passing through the path adjuster, a measurement light related to a target material.

Abstract: Systems and methods applicable, for instance, to pipette robots. A pipette robot can perform one or more operations regarding deck calibration, one or more operations regarding pipette tip/probe calibration, one or more operations regarding pipette tip pick up, and/or one or more operations regarding tip ejection.