Patents Examined by R Jarrett
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Patent number: 11529629Abstract: The present invention relates to a biosensor, including: a blood cell separation membrane which separates blood cells from blood and allows plasma components to pass through; a microfluid channel through which the plasma components that have passed through the blood cell separation membrane flow; a lower substrate which allows the plasma components that have passed through the blood cell separation membrane to flow along the microfluid channel; and a pillar which connects the blood cell separation membrane and the lower substrate, in which an electrode is disposed in the pillar, and the pillar pushes and lifts the blood cell separation membrane by a predetermined distance. The biosensor of the present invention allows plasma, which is difficult to pass through the blood cell separation membrane due to surface tension, to easily pass through.Type: GrantFiled: May 12, 2020Date of Patent: December 20, 2022Assignee: BBB INC.Inventors: Hyundoo Hwang, Dongsik Han, Jaekyu Choi
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Patent number: 11524292Abstract: Embodiments of the invention provide a microfluidic chip having microfluidic structures formed on a surface. The structures form an input channel, an output channel, auxiliary channels, and a hydraulic resistor structure connecting the input channel to the output channel via the auxiliary channels. The resistor structure includes N flow resistor portions (N?2), which are connected to the auxiliary channels. The chip further includes at least N?1 actuatable valves, which are arranged in respective ones of the auxiliary channels. The actuation state of the valves can determine the effective hydraulic resistance of the resistor structure. The valves can be electrogates, each including a liquid-pinning trench arranged in a respective one of the auxiliary channels that define a flow path for a liquid introduced therein, so as to form an opening that extends across said flow path. Each electrogate can further include an electrode extending across the flow path.Type: GrantFiled: February 21, 2019Date of Patent: December 13, 2022Assignee: International Business Machines CorporationInventors: Marie Salva, Yuksel Temiz, Yulieth Cristina Arango, Onur Gökçe, Emmanuel Delamarche
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Patent number: 11504713Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.Type: GrantFiled: March 11, 2020Date of Patent: November 22, 2022Assignee: Genzyme CorporationInventors: Tarl Vetter, Kevin Brower
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Patent number: 11491486Abstract: Aspects of the present disclosure describe systems, methods, and structures for acoustic wave-based separation of particulates in a fluidic flow. Illustrative systems, methods, and structures according to aspects of the present disclosure may advantageously provide for the continuous, label-free, non-invasive separation of the particulates that include—among other types—difficult-to-separate biological particulates and in particular those in blood including circulating tumor cells and micro-blood-borne particles and other subgroups of extracellular vesicles including nanoscale exosomes.Type: GrantFiled: August 29, 2018Date of Patent: November 8, 2022Assignee: Duke UniversityInventors: Jun Huang, Mengxi Wu
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Patent number: 11493522Abstract: A fixed bed (10) is provided for a fixed-bed reactor (100). The fixed bed (10) contains a particulate carrier and at least one reactive substance. The carrier is a silicate compound and the reactive substance is an organometallic pyridine compound. A method for preparing such a fixed bed is provided. The method includes the steps of preparing the carrier, preparing an impregnation and treating the carrier with the impregnation. In addition, a gas-measuring tube is provided with a correspondingly prepared fixed bed as well. A method uses organometallic pyridinium compounds, especially pyridinium dichromate, in a fixed-bed reactor for detecting alcohol compounds and for preparing formaldehyde and/or acetaldehyde.Type: GrantFiled: May 11, 2016Date of Patent: November 8, 2022Assignee: DRÄGER SAFETY AG & CO. KGAAInventors: Jan Boeckmann, Stefanie Brett
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Patent number: 11484878Abstract: Disclosed is method of manufacturing a microchannel chip by joining together a resin channel substrate having microchannels formed on at least one side thereof and a resin lid substrate, the method including: a step (A) wherein surface modification treatment is applied on joining surfaces of the channel substrate and the lid substrate; and a step (B) wherein, after the step (A), the joining surfaces of the channel substrate and the lid substrate are mated and the channel substrate and the lid substrate are pressurized under heating via a fluid or an elastic body having a durometer hardness of E20 or less.Type: GrantFiled: March 14, 2018Date of Patent: November 1, 2022Assignee: ZEON CORPORATIONInventors: Daido Chiba, Kunihito Arai, Taichi Sawaguchi, Mitsukazu Aizawa, Noriyuki Aritome
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Patent number: 11478793Abstract: In an example implementation, a microfluidic device includes a first layer with a first microfluidic channel and a second layer with a second microfluidic channel. The first and second channels are adjacent to one another at a channel intersection, and a conductive membrane valve extends across and covers the channel intersection to separate the first and second channels. The microfluidic device includes a conductive trace to open the membrane valve and join the first and second channels by supplying an electric current to heat and melt a thinned region of the membrane valve.Type: GrantFiled: October 30, 2017Date of Patent: October 25, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Viktor Shkolnikov, Chien-Hua Chen, Michael W Cumbie
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Patent number: 11480563Abstract: Medical test cards for detecting analytes are provided including a substantially planar body, an analyte detection means, an opening feature, and an optical code. The analyte detection means is enclosed within the planar body and is configured to provide a colorimetric change when a portion of the analyte detection means is contacted with the analyte. The opening feature is configured to provide access to the analyte detection means and the optical code includes information identifying the analyte detection means. Uses of such medical test cards include accessing the analyte detection means enclosed within the planar body by using the opening feature and contacting the analyte detection means with the sample. The optical code is read using an imaging device to identify the analyte detection means and the analyte detection means is imaged following contact with the sample using the imaging device.Type: GrantFiled: March 25, 2019Date of Patent: October 25, 2022Assignee: TestCard Ltd.Inventors: Luke Heron, Andrew Botham
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Patent number: 11467069Abstract: The sampling chip dividing instrument includes: a main body block; a space that is provided inside the main body block, has an opening leading to an outer surface of the main body block, and fits in and contains the cut portion of the sampling chip through the opening; and an surrounding portion that is provided outside the space at a periphery of the opening, and receives a sample scattered from a break portion of the sampling chip divided near the opening.Type: GrantFiled: January 5, 2017Date of Patent: October 11, 2022Assignee: SHIMADZU CORPORATIONInventors: Ippei Takauchi, Shinobu Kudoh
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Patent number: 11467459Abstract: An electrochromic device comprising a substrate, a set of electrodes disposed on or within the substrate, and a layer comprising ?-WO3 disposed in electrical communication with the set of electrodes, wherein the layer of ?-WO3 exhibits polarization switching are described. Methods of making and using the electrochromic devices are also described. The electrochromic devices are used for detecting acetone in a fluid. The observed change in color of the ?-WO3 layer can be correlated with a subject's medical condition, such as diabetes.Type: GrantFiled: February 5, 2019Date of Patent: October 11, 2022Assignee: Ohio State Innovation FoundationInventors: Pelagia I. Gouma, Owen Oladele Abe
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Patent number: 11454637Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.Type: GrantFiled: April 24, 2020Date of Patent: September 27, 2022Assignee: Quest Diagnostics Investments IncorporatedInventors: Cory Bystrom, Shijun Sheng, Nigel Clarke, Richard E. Reitz
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Patent number: 11440008Abstract: Examples include microfluidic devices. Example microfluidic devices comprise a microfluidic channel, a capillary chamber, and a fluidic actuator. The microfluidic channel is fluidly connected to the capillary chamber. The capillary chamber is to restrict flow of fluid therethrough. The fluidic actuator is positioned proximate the capillary chamber. The fluidic actuator is to actuate to thereby initiate flow of fluid through the capillary chamber.Type: GrantFiled: April 14, 2016Date of Patent: September 13, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Devin Alexander Mourey, Michael W Cumbie, Garrett E Clark
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Patent number: 11440010Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.Type: GrantFiled: December 7, 2021Date of Patent: September 13, 2022Assignee: Genzyme CorporationInventors: Tarl Vetter, Kevin Brower
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Patent number: 11426724Abstract: Systems and methods for using microfluidic devices to concentrate cells, to perform buffer changes, to sort cells based on size, and/or to isolate particular types of cells in a rapid manner, are presented. Cells flow into a matrix of posts, wherein the posts are distributed along diagonal lines in the chamber. The cells are deflected in a lateral manner, towards a side of a chamber and are collected upon exiting the chamber.Type: GrantFiled: January 10, 2019Date of Patent: August 30, 2022Assignee: NANOCAV, LLCInventor: Yu-Chun Kung
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Patent number: 11408804Abstract: A pathological specimen preparation device includes a stage portion including a stage, a reagent supply portion 150 capable of supplying a reagent to a substrate W mounted on the stage, a washing portion capable of supplying a washing solution to the substrate, an electric field stirring portion capable of stirring the reagent or the washing solution supplied to the substrate by applying an electric field to the reagent or the washing solution, and a control unit, wherein the washing portion, the reagent supply portion, and the electric field stirring portion are sequentially disposed in a Y direction as a first direction, and the device includes a stage transport mechanism that moves the stage in the Y direction, and a stage tilting mechanism that tilts the stage in an X direction as a second direction crossing the Y direction when the stage is positioned in the washing portion.Type: GrantFiled: August 31, 2017Date of Patent: August 9, 2022Inventors: Taro Aoki, Tadashi Sato, Yoichi Suzuki, Masayuki Kadota, Ryo Sato
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Patent number: 11408854Abstract: A diagnostic device is described herein that can be used to perform magneto-optical detection and discernment of crystals within a biofluid sample. A magnetic field can be applied by the diagnostic device in a direction relative to light traveling through the sample. The presence of a crystal can be determined based on the magneto-optical properties of the sample. The detected crystal can be one of two similar crystal types that may be in the biofluid sample. The two similar crystal types can exhibit different magneto-optical properties under a magnetic field in a different direction. Accordingly, the type of crystal can be discerned by applying the magnetic field in the different direction as light travels through the sample. Discernment of the type of crystal can lead to diagnosis of the particular disease condition and subsequent proper treatment of the disease condition.Type: GrantFiled: August 25, 2017Date of Patent: August 9, 2022Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Tanvir Baig, Robert Brown, Robert Deissler, Brian T. Grimberg, Abdullah Amin
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Patent number: 11389803Abstract: Disclosed is a liquid sending method for sending liquid to a sample processing chip having a flow path formed therein, the method including: measuring a flow of a second liquid which is different from a first liquid which is introduced into the flow path in the sample processing chip; controlling the flow of the second liquid on the basis of the measured flow; and introducing the first liquid into the flow path in the sample processing chip by means of the second liquid of which flow is controlled.Type: GrantFiled: February 26, 2018Date of Patent: July 19, 2022Assignee: SYSMEX CORPORATIONInventors: Kunpeng Cai, Koya Yamawaki, Yasuko Kawamoto, Katsumi Nakanishi, Ayato Tagawa
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Patent number: 11390837Abstract: A microchannel device includes: a channel unit which is configured of a plurality of channel members which are laminated in a thickness direction to define a microchannel, at least one of the channel members being made of a material having elasticity; and a holding member which is provided separately from or integrally with the channel unit and holds the channel unit in a state of being compressed in the thickness direction.Type: GrantFiled: November 25, 2019Date of Patent: July 19, 2022Assignee: FUJIFILM CORPORATIONInventors: Takahiro Oba, Akira Wakabayashi, Koju Ito
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Patent number: 11385146Abstract: Sampling systems and techniques that increase pickup efficiency and shedding efficiency of an analyst of interest collected from a surface are provided. In one aspect, an absorbent swab collects an analyte of interest, such as a hazardous contaminant, from a test area demarcated by a template. The sampling techniques can include swab speed and force protocols specifying how fast and how hard the user should apply the swab across the surface to improve pickup efficiency. The sampling techniques can include instructions for inverting a container enclosing the swab and collected contaminant to improve shedding efficiency from the swab.Type: GrantFiled: September 18, 2018Date of Patent: July 12, 2022Assignee: Becton, Dickinson and CompanyInventors: Weston F. Harding, Austin Jason Mckinnon, Matthew Oshinski
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Patent number: 11385165Abstract: According to some aspects, a sample isolation kit is provided. The sample isolation kit includes a housing configured to detachably couple to a sample fluid channel of a microchip and provide a sample to the microchip. The housing and the microchip are coupled using a hermetic seal. The sample isolation kit further includes a storage housing configured to detachably couple to an isolation channel of the microchip and receive a target biological sample isolated from the sample by the microchip. The storage housing and the microchip are coupled using a hermetic seal.Type: GrantFiled: March 10, 2017Date of Patent: July 12, 2022Assignee: Sony CorporationInventors: Yoichi Katsumoto, Masahiro Matsumoto, Kazuya Takahashi