Abstract: Polypeptide epitopes are defined herein which when used as components of vaccine compositions, induced partial immunity to Schistosoma mansoni. The epitopes are found on the surface of schistosomula. The epitopes are part of larger proteins which are immunologically cross-reactive with myosin heavy chains from other species. However, anti-myosin antibodies directed against myosin molecules of other species are not cross-reactive with the surface epitopes of S. mansoni.
Abstract: The present disclosure is directed to improved pharmaceutical compositions employing interferon-gamma which have been treated to remove interferon-gamma inhibitory activity associated with such preparations. In addition, the present disclosure details treatment protocols, including the elevation of patient body temperature and the use of combined or sequential interferon-gamma treatments, to enhance interferon-gamma efficacy and reduce the resistance associated with interferon-alpha and/or beta therapy.
Type:
Grant
Filed:
May 14, 1990
Date of Patent:
July 9, 1991
Assignee:
Board of Regents, The University of Texas System
Abstract: Hybrid procoagulant proteins are disclosed which contain peptide sequences of human blood coagulation factors V and VIII. DNA molecules encoding these proteins and materials and methods for expressing them are also disclosed. Preferably, peptide sequence in the B domain of Factor VIII is replaced with peptide sequence derived from human Factor V.
Abstract: "Iscom" adjuvant matrices, comprising a sterol, a glycoside, a solubilized water-insoluble antigen and, optionally, a phospholipid, may be formed without removing the solubilizing agent used for the antigen. The glycoside is preferably Quil A and the sterol is preferably cholesterol.
Type:
Grant
Filed:
October 24, 1989
Date of Patent:
January 1, 1991
Assignee:
Coopers Animal Health Limited
Inventors:
Neill M. MacKenzie, Angela M. O'Sullivan
Abstract: The present invention provides a novel polypeptide which shows higher IFN-.gamma. activity than intact IFN-.gamma. and a method of producing the same.The polypeptides not only possess a remarkable antiviral activity, antitumor activity, immunopotentiating activity but also is highly stable, therefore, it can be used advantageously as pharmaceuticals.
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