Patents Examined by R. Phillips
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Measuring circuit for impedance values particularly for use with inductive displacement transmitters
Patent number: 5444381Abstract: A measuring circuit (MS) for measuring the value of an impedance in an impedance network includes an oscillator device (OSZ1), a second oscillator device (OSZ2), a phase-controlled rectifier (PG), a reference/actual value comparison point (AG) and an integrator.The first oscillator device feeds a first alternating voltage of constant amplitude and constant frequency to a first output connection (A1). The second oscillator device feeds a second alternating voltage of the same frequency, but with adjustable amplitude and with phase shifted by 180.degree., to a second output connection (A2). The amplitude of the second alternating voltage depends on the phase of the signal which is transmitted to the phase-controlled rectifier via an input connection (E). If the input signal is in phase with the second output signal, the amplitude of the second output signal is reduced. However, if the input signal oscillates in opposite phase to the second output signal, the amplitude of the second output signal is increased.Type: GrantFiled: April 17, 1991Date of Patent: August 22, 1995Assignee: Robert Bosch GmbHInventors: Johannes Locher, Werner Fischer, Joerg Barth -
Patent number: 5432442Abstract: An air gap detector for use in antilocking brake systems includes an active integrator that integrates an output signal from a wheel speed sensor, that depends in part on the relative spacing between the wheel axle and its associated bearing, to thereby produce a signal that is inversely proportional to the air gap between the axle and bearing. The integrated signal is processed by peak detecting means to produce a peak signal that is proportional to the size of the air gap. The peak signal is then amplified and adjusted to produce a D.C. signal that is proportional to the size of the air gap.Type: GrantFiled: July 30, 1993Date of Patent: July 11, 1995Assignee: ITT CorporationInventor: Robert G. Andersen
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Patent number: 5426369Abstract: A new and improved spark plug testing apparatus is in the form of an electrically conductive, metallic spring clip and includes a pair of first electrically conductive contact portions for contacting an electrically conductive externally threaded portion of a spark plug. A first resilient portion is connected to the pair of first electrically conductive contact portions for clamping the first electrically conductive contact portions onto the electrically conductive externally threaded portion of the spark plug. A pair of second resilient portions is connected to the respective first electrically conductive contact portions, and a pair of second electrically conductive contact portions is connected to the respective second resilient portions, such that the first resilient portion urges the second electrically conductive contact portions onto an electrically conductive internally threaded portion of a spark plug receiving aperture on an internal combustion engine.Type: GrantFiled: August 31, 1993Date of Patent: June 20, 1995Inventor: Reiner G. Brinker
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Patent number: 5424641Abstract: A SQUID fluxmeter, which object is to accurately measure magnetic flux even if the input magnetic flux is largely changed in a short time, includes an 1-input superconducting OR gate for outputting pulses to the number of i in response to one input pulse from a SQUID, an AC bias current source for outputting a current I.sub.C of variable frequency 4if to a bias input node of the OR gate, an up/down counter for counting pulses from the SQUID and a control circuit for outputting a control signal CSi to the AC bias current source corresponding to the time differential value of the count value C1 of the counter and present value i. The response speed of the magnetic flux feedback through the feedback coil to the SQUID in response to the magnetic flux input to the SQUID is thereby made i times higher than that in the prior art.Type: GrantFiled: July 26, 1993Date of Patent: June 13, 1995Assignee: Fujitsu LimitedInventor: Kohtaroh Gotoh
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Patent number: 5414353Abstract: A magnetic inspection device for detecting structural faults in elongated magnetically permeable objects has two opposite magnetic poles, at least one pole being an end pole, that induce a first magnetic flux axially in a first section of an object between the poles, and an oppositely directed magnetic flux in another section adjacent the end pole. As the device and object move relative to one another, eddy currents induced in the object by the changing longitudinal fluxes at the end pole are detected to locate structural faults in the object.Type: GrantFiled: May 14, 1993Date of Patent: May 9, 1995Assignee: NDT Technologies, Inc.Inventor: Herbert R. Weischedel
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Patent number: 5399967Abstract: A motion transducer for measuring the displacement of, for example, shafts in gas control modules. The shaft 14 carries two magnets 10, 12 each of hollow cylindrical form, the magnet 10 presenting a south pole everywhere over its external cylindrical face and the magnet 12 presenting a north pole everywhere over its external cylindrical face. The shaft 14 moves vertically past an array of Hall-effect sensors 18-24 to produce sinusoidal voltage outputs at the sensors. The outputs are combined in a summing amplifier (FIG. 3). The combined output is not affected by rotation of the shaft and magnets nor by tilting or sideways displacement of the axis 16 of the shaft. That is because no matter what the rotational position is the sensors are always subjected to the same magnetic field and, if the shaft tilts or is displaced sideways an increased field at some sensors is compensated by a decreased field at others.(FIG. 1 is suggested as the accompanying drawing).Type: GrantFiled: March 15, 1993Date of Patent: March 21, 1995Assignee: British Gas plcInventor: Ian A. Carscadden
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Patent number: 5399964Abstract: A peak amplitude detector for use in a synchronized position demodulator associated with a linear variable differential transformer. The peak amplitude detector adjusts for phase shift in the transformer and maintains the full bandwidth of the transformer. The detector obtains the maximum positive or negative amplitude of the sinusoidal signal at one of the secondary windings of the transformer by first counting either a positive or negative half cycle of the signal and then while down counting one half of the counted half cycle sampling the amplitude of the sinusoidal signal. The sampling ends when the count reaches zero.Type: GrantFiled: August 23, 1993Date of Patent: March 21, 1995Assignee: Elsag International N.V.Inventor: Allan C. Zoller
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Patent number: 5381095Abstract: A method for real time processing of information received from a plurality of permanent magnets embedded in the pavement of an Intelligent Vehicle Highway System. A sequence of magnet orientations provides coded information to sensors mounted on automotive vehicles. The method uses a combination of extended Kalman filtering and Schweppe likelihood estimation to determine the relative location and orientation of the magnets. A separate location estimator (extended Kalman filter) is provided for each of the possible magnet orientations. A decision process identifies the most likely orientation of the magnet, and the Kalman filter selected by the process contains the best estimate of the location of the magnet. Schweppe likelihood estimation is extended to use the detector as a decoder of the information provided by the orientation sequence of the magnets.Type: GrantFiled: June 21, 1993Date of Patent: January 10, 1995Assignee: Rockwell International CorporationInventor: Angus P. Andrews
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Patent number: 5019390Abstract: The present invention relates to a novel antineoplastic agent, designated IMIC (Inhibitor of Mevalonate Incorporation Into Cholesterol) having the following characteristics:(a) is present in the retentate of dialyzed skim milk;(b) is non-dialyzable;(c) has general properties of pyrimidines;(d) is bound to a protein in the proteose-peptone fration of milk;(e) is soluble in water;(f) is insoluble in organic solvents;(g) is stable in acid;(h) is not bound or retained by a C.sub.18 or C.sub.8 reverse phase HPLC columns;(i) is not retained by a C.sub.18 or silica gel sep. pak;(j) has .lambda. maximum absorbance at 208 nm and 278 nm (UV) in neutral ad acidic solution and in a basic solution at 223 and 290 nm;(k) provides peaks with a retention time of 7.52 minutes upon fractionation by HFLC on a Biorad Aminex resin column (30 cm .times.7.9 nm) with 0.05 NH.sub.2 SO.sub.4 as the mobile phase and with a flow rate of 0.7 ml/minute;(l) provides peaks with a retention time of 9.Type: GrantFiled: May 29, 1987Date of Patent: May 28, 1991Assignee: Research Corporation Technologies, Inc.Inventors: Robert D. McCarthy, deceased, Arun Kilara, David B. Pierce
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Patent number: 4959354Abstract: The mixturex of FSH ( follicle stimulating hormone) and LH ( luteinizing horomone) being extracted from pig hypophyses in a definite ratio, improve to an optimum level the induction of super-ovulation in bred animals.Type: GrantFiled: July 14, 1987Date of Patent: September 25, 1990Assignee: Istituto Farmacologico Serono S.p.A.Inventor: Manlio Barbetti
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Patent number: 4954638Abstract: Leukotrienes may be conjugated with various proteins such as Bovine Serum Albumin (BSA) and Hemocyanin from Giant Keyhole Limpets (KLH) using 1,5-difluoro-2,4-dinitrobenzene or 6-N-maleimidohexanoic acid chloride as coupling agents.These conjugates are useful as reagents in a newly developed immunoassay for leukotrienes, as well as having potential utility as chemical immunotherapeutic agents in the treatment of various allergic and chronic inflammatory diseases of the skin, lung, and airways, including asthma, allergic rhinitis, rheumatoid arthritis, and skin diseases such as psoriasis and eczema.Type: GrantFiled: August 1, 1988Date of Patent: September 4, 1990Assignees: Merck Frosst Canada, Inc., Merck & Co., Inc.Inventors: Robert N. Young, Joshua Rokach, Edward C. Hayes
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Patent number: 4935235Abstract: What is disclosed is a protein immunoreactive with antibodies raised against HBsAg, which protein has the formula: X-S-Y, S represents a peptide residue of the hepatitis B virus S-protein, Y is OH or NH.sub.2 and X is selected from the pre-S1/pre-S2 peptide residue, the pre S2 peptide residue and a fragment of the pre-S1/pre-S2 peptide residue containing at least a 9 amino acid portion of the C-terminal sequence of pre-S2.Type: GrantFiled: December 1, 1987Date of Patent: June 19, 1990Assignee: The Regents of the University of CaliforniaInventors: William J. Rutter, Howard M. Goodman
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Patent number: 4919930Abstract: Synthetic peptide segments of protein Pep M5 containing epitopes capable of evoking type specific opsonic antibodies against streptococci when covalently linked to a protein carrier.Type: GrantFiled: May 1, 1986Date of Patent: April 24, 1990Assignee: University of Tennessee Research CorporationInventors: Edwin H. Beachey, James B. Dale
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Patent number: 4916119Abstract: Tripeptides of the general formula: ##STR1## wherein the symbols R, which may be the same or different represent hydrogen or a fatty acid residue (at least one of them representing a fatty acid residue), R.sub.1 represents hydroxy, amino or alkoxy and R.sub.2 and R.sub.3, which may be the same or different, represent hydrogen, carboxy, carbamoyl or alkoxycarbonyl radical (with the proviso that R.sub.2 and R.sub.3 cannot simultaneously represent a hydrogen atom), the alanine moiety being in the L form, the glutamic acid moiety being in the D form, the lysine moiety (when R.sub.2 or R.sub.3 =a hydrogen atom) being in the L form and the 2,6-diaminopimelic acid moiety or its derivatives (when R.sub.2 and/or R.sub.3 =carboxy, carbamoyl or alkoxycarbonyl) being in the D,D, L,L, D,D/L,L (racemic) or D,L (meso) form, and salts thereof, possess immunological adjuvant and immunostimulant activity.Type: GrantFiled: June 27, 1980Date of Patent: April 10, 1990Assignee: Rhone-Poulenc IndustriesInventors: Jean Bouchaudon, Daniel Farge, Claude James
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Patent number: 4914189Abstract: Human pancreatic GRF (hpGRF), rat hypothalamic GRF (rGRF) and porcine hypothalamic GRF (pGRF) have been earlier characterized and synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in animals, including humans, which have resistance to enzymatic degradation in the body, and which have the sequence: ##STR1## wherein Q.sup.1 is an omega or alpha-omega substituted alkyl,Q.sup.2 is a lower omega-quanidino-alkyl group.R.sub.2 is Ala, D-Ala, or D-N-Methyl-AlaR.sub.3 is Asp, D-Asp, Glu, or D-GluR.sub.8 is Asn, D-Asn, Ser, or D-SerR.sub.10 is Tyr or D-TyrR.sub.12 is Lys, D-Lys Arg or OrnR.sub.13 is Val or IleR.sub.14 is Leu or D-LeuR.sub.15 is Gly, N-Methyl-Gly, or D-AlaR.sub.17 is Leu or D-LeuR.sub.18 is Tyr or SerR.sub.23 is Leu or D-LeuR.sub.24 is Gln or HisR.sub.25 is Asp, D-Asp, Glu, or D-GluR.sub.27 is Met, D-Met, Ala, Nle, Ile, Val, Nva, LeuR.sub.Type: GrantFiled: February 5, 1987Date of Patent: April 3, 1990Assignee: The Adminstrators of the Tulane Educational FundInventors: Andrew V. Schally, Jozsef Gulyas, Sandor Bajusz
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Patent number: 4910190Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.Type: GrantFiled: January 20, 1987Date of Patent: March 20, 1990Assignee: ICI Americas Inc.Inventors: Scott H. Bergeson, Philip D. Edwards, John A. Schwartz, Andrew Shaw, Mark M. Stein, Diane A. Trainor, Richard A. Wildonger, Donald J. Wolanin
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Patent number: 4910296Abstract: Fragments of Alpha-1 thymosin ranging from two to twelve peptides in length nd pharmaceutically acceptable salts thereof. These fragments possess immunostimulatory and immunoregulatory properties similar to the alpha thymosin molecule and are useful in the same fashion as in this molecule.Type: GrantFiled: June 26, 1986Date of Patent: March 20, 1990Assignee: Max-Planck-Gesellschaft zur Foederung der Wissenschaften e.V.Inventors: Christian Birr, Ilona Werner, Ulrich Stollenwerk, deceased, by Paul Stollenwerk, heir, by Margot Stollenwerk, heir
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Patent number: 4908352Abstract: Maggy UI (Urotensin I) or flathead sole urotensin, obtained from Hippoglossides Elassodon has the formula: H-Ser-Glu-Glu-Pro-Pro-Met-Ser-Ile-Asp-Leu-Thr-Phe-His-Met-Leu-Arg-Asn-Met- Ile-His-Arg-Ala-Lys-Met-Glu-Gly-Glu-Arg-Glu-Gln-Ala-Leu-Ile-Asn-Arg-Asn-Leu -Leu-Asp-Glu-Val-NH.sub.2. Analogs have been synthesized that are at least as potent as Maggy UI, and Maggy UI or such an analog or a biologically active fragment of either or pharmaceutically acceptable salts of any of the foregoing, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals to achieve a substantial elevation of ACTH, .beta.-endorphin, .alpha.-lipotropin and corticosterone levels and/or an increase in intestinal blood flow and/or a lowering of systemic blood pressure and/or a changing of regional blood distributio over an extended period of time.Type: GrantFiled: September 28, 1987Date of Patent: March 13, 1990Assignee: The Salk Institute for Biological StudiesInventors: Karl P. Lederis, Denis McMaster, Jean E. F. Rivier
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Patent number: 4906615Abstract: A method for inhibiting the action of enkephalinases in a mannal to thereby elicit an analgesic effect in said mammal is described.Novel compounds and compositions useful for accomplishing the method of the invention are also described.Type: GrantFiled: October 26, 1987Date of Patent: March 6, 1990Assignee: Schering CorporationInventor: Joel G. Berger
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Patent number: 4906614Abstract: A method of preventing or treating posttraumatic nervous injuries by administering a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups ##STR2## if Z is a group (a), R.sub.2 and R.sub.3 together represent an additional bond between the carbon atoms bearing them, or if Z represents a group (b), R.sub.2 is hydrogen; R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or phenyl, and R.sub.6 is hydrogen or methyl. Hydrates or pharmaceutically acceptable acid addition salts may also be used in the method. Pharmaceutical compositions used in this method containing such compounds in a prophylactically or therapeutically effective amount may be administered by infusion, injection, orally, perorally, rectally, percutaneously or other route.Type: GrantFiled: June 14, 1988Date of Patent: March 6, 1990Assignee: Gruenenthal GmbHInventors: Hubert Giertz, Hans Barth, Leopold Flohe