Abstract: The present technology provides an illustrative method for analyte monitoring using surface plasmons with a refreshable surface. The method includes placing a solution to be monitored in contact with a working surface of a surface plasmon resonance (SPR) generation system. The working surface includes a metal surface disposed on a glass surface, and the metal surface includes a first binding substance that provides binding sites for an analyte. The method further includes applying light to the metal surface at a plurality of angles over a period of time, measuring a reflectance of the light at each of the plurality of angles to determine an SPR angle, and monitoring changes to the SPR angle over the period of time. The working surface of the SPR generation system is refreshed by depositing a new layer of the first binding substance on the working surface of the SPR generation system.