Abstract: Compounds of the formula ##SPC1##WhereinA is alkylene of 2 to 6 carbon atoms,R.sub.1 is hydrogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy,R.sub.2 is hydrogen, lower alkyl or lower alkoxy,R.sub.3 is hydrogen, methyl or ethyl,R.sub.4 is hydrogen, lower alkyl or lower alkoxy,R.sub.5 is hydrogen, hydroxyl, lower alkanoyloxy or lower alkyl-sulfonamido, andR.sub.6 is hydrogen or lower alkanoyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as peripheral vasodilators, antihistaminics and spasmolytics.

Abstract: N,N'-disubstituted-p-phenylenediamines, e.g., N-(3-isopropoxypropyl)-N'-(2-octyl)-p-phenylenediamine or N-phenethyl-N'-(2-octyl)-p-phenylenediamine, are prepared by condensing phenylenediamines with an alkyl carbonyl in the presence of a reducing catalyst, and are useful as hypolipidemic and anti-obesity agents.

Abstract: A continuous process is described for the preparation of methylene-bridged polyphenyl polyamines containing di(aminophenyl)methane having a high, p,p'-isomer content (at least 98 percent by weight). Fluid streams of aqueous aniline hydrochloride solution and aqueous formaldehyde are intermixed at one end of a continuous tubular reactor, passed therethrough at 0.degree.C to 75.degree.C in about 3 seconds to about 120 seconds, thence to recycle in a cooling zone (less than 60.degree.C), optionally to a holding zone (temperature less than 70.degree.C) and finally to a final reaction zone (temperature 60.degree.C to 120.degree.C) to complete the reaction. The diamine content in the polyamines is controlled by molar ratio of aniline hydrochloride to formaldehyde in the feeds. Preferably the holding zone, where employed, and final reaction zone comprise a continuous tubular vessel.

Abstract: Compounds of the formula ##EQU1## wherein n is 4 or 5, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as .beta.-adrenergic receptor blocking agents.

Abstract: This invention relates to new tetrahydronaphthyloxy-aminopropanols and related compounds of the formula ##SPC1##And to salts of such compounds, which are useful in coronary diseases.

Abstract: N,N'-Bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or-2-hydroxyethyl]-polymethylenediamines having .beta.-adrenergic stimulant activity particularly as selective bronchodilators, are prepared generally by condensation of an N-benzylphenethylamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylenediamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon. The key intermediates are also part of the invention.

Abstract: Amine derivatives of 1,2,3,4-tetrahydro-1,4-alkanonaphthalenes, and the use of such compounds to control viral infections, particularly influenza viruses, in warm-blooded animals are disclosed. Pharmaceutical compositions containing an effective amount of the novel compounds and a pharmaceutically acceptable carrier are also disclosed.

Abstract: Preparation and isolation in substance of ortho-aminothiphenols by the reduction of ortho-chloronitrobenzenes with hydrogensulfides or sulfides, subsequent neutralization in the presence of sulfites, hydrogensulfites or disulfites, separation and following purification of the crude products. The ortho-aminothiophenols are obtained in very good yields and with a high degree of purity. Oxydation to the disulfide compound is avoided by the processes of the invention.

Abstract: A process for the production of aromatic polyamines comprising condensing primary or secondary aromatic amines with formaldehyde or a formaldehyde precursor in the presence of an acid catalyst and liberating the polyamines on completion of condensation by the addition of a basically reacting reagent, wherein a mixture containing amine, catalyst, aldehyde, precondensates formed therefrom, and water, issuing from a mixer at a maximum temperature of about 40.degree.C., is separated intoA. a side stream in which the heat liberated from the reacting mixture is dissipated in a heat exchanger following dilution of the total quantity of mixture of amine and catalyst, cooled to below about 40.degree.C., required for the reaction and the mixture thus obtained is reintroduced at a temperature of at most about 40.degree.C. into the mixer where formaldehyde is added, andB. a main stream which is pumped, through a reaction zone kept at a maximum of about 40.degree.C.