Patents Examined by R. W. Ramsuer
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Patent number: 5753695Abstract: The invention relates to a compound of formula (I) ##STR1## wherein X is a pharmacologically acceptable anion,R.sub.1 and R.sub.2 are independently of each other hydrogen, or an --OY group in which Y is hydrogen, an .alpha.-aminoacyl, or a C.sub.1-5 aminoalkyl residue,R.sub.3, R.sub.4 and R.sub.7 are independently of each other hydrogen, or a C.sub.1-5 alkyl residueR.sub.5 is hydrogen, and .alpha.-aminoacyl, or a C.sub.1-5 alkyl residue, andR.sub.6 is hydrogen, OH.sup.-, or a C.sub.1-5 alkyl residue,and pharmaceutically acceptable salts and esters thereof; and to condensation processes for preparing them.Type: GrantFiled: May 19, 1994Date of Patent: May 19, 1998Assignee: Biogal Gyogyszergyar RTInventors: Gyorgy Sulyok, Janos Balint, Ildiko Borbely, Jolan Kiss, Ferenc D. Toth
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Patent number: 5506254Abstract: Pyrazolyl derivatives of the general formula I ##STR1## where the indices and the substituents have the following meanings: n is is 0, 1, 2, 3 or 4, it being possible for the radicals R.sup.1 to be different if n is greater than 1;m is 0, 1 or 2, it being possible for the radicals R.sup.3 to be different if m is greater than 1;R.sup.1 is nitro, cyano, halogen,alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio,unsubstituted or substituted phenyl or phenoxy;R.sup.2 is hydrogen,unsubstituted or substituted alkyl, alkenyl or alkynyl,an unsubstituted or substituted, saturated or mono- or diunsaturated ring,an unsubstituted or substituted, mono- or binuclear aromatic radical;R.sup.3 is nitro, cyano, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy;R.sup.4 is hydrogen, cyano, halogen, alkyl or haloalkyl,processes for their preparation and their use are described.Type: GrantFiled: July 6, 1995Date of Patent: April 9, 1996Inventors: Reinhard Kirstgen, Hartmann Konig, Hubert Sauter, Volker Harries, Gisela Lorenz, Eberhard Ammermann
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Patent number: 5470863Abstract: A description follows of oximic derivatives with a fungicide activity, for agricultural use, having the formula (I): ##STR1## wherein: A, B, D, are N, or .dbd.C--G;G is H, halogen, NO.sub.2, CN, --COOR.sub.4, C.sub.1 -C.sub.6 (halo)alkylR.sub.1, R.sub.2, R.sub.4 and R.sub.5, are C.sub.1 -C.sub.6 (halo)alkyl;R.sub.3 is H, C.sub.1 -C.sub.6 (halo)alkyl or --COOR.sub.5 ;W is C.sub.2 -C.sub.10 alkylene;L represents O or S;Y represents phenyl, naphthyl, heterocycle, substituted alkyl.Type: GrantFiled: September 10, 1992Date of Patent: November 28, 1995Assignees: Ministero Dell'Universita' E Della Ricerca Scientifica E TechnologicaInventors: Giovanni Camaggi, Lucio Filippini, Marilena Gusmeroli, Giovanni Meazza, Giampaolo Zanardi, Carlo Garavaglia, Luigi Mirenna
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Patent number: 4973587Abstract: Antiglaucoma compositions containing 3-aryl-carbonyl-1-aminoalkyl-1H-indoles, as the active component thereof, and a method of use thereof in the treatment of glaucoma.Type: GrantFiled: March 8, 1990Date of Patent: November 27, 1990Assignee: Sterling Drug Inc.Inventors: Susan J. Ward, Malcolm R. Bell
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Patent number: 4892958Abstract: A process for the preparation of a 5-amino-1-phenyl-4-nitropyrazole of the formula ##STR1## in which Ar is optionally substituted phenyl, which comprises reacting an arylhydrazine of the formulaAr--NH--NH.sub.Type: GrantFiled: December 8, 1988Date of Patent: January 9, 1990Assignee: Bayer AktiengesellschaftInventor: Hauke Furstenwerth
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Patent number: 4775680Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.Type: GrantFiled: July 21, 1987Date of Patent: October 4, 1988Assignee: Merck & Co., Inc.Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard
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Patent number: 4379936Abstract: 3.alpha.-Benzoylamino-2.beta.-hydroxy-nortropanes substituted in the 8-position by an alkoxycarbonyl or alkanoyl group, useful as analgesics, are prepared by reacting the corresponding 2.beta.,3.beta.-epoxy-nortropane with benzylamine in the presence of phenol.Type: GrantFiled: April 19, 1982Date of Patent: April 12, 1983Assignee: Sterling Drug Inc.Inventor: Robert L. G. Clarke
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Patent number: 4370347Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.Type: GrantFiled: October 19, 1981Date of Patent: January 25, 1983Assignee: Pierre Fabre S.A.Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
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Patent number: 4337252Abstract: The compounds have the formula: ##STR1## in which R is OH, OCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2 or OCH.sub.2 --C.tbd.CH, or a halogen atom, as well as their addition salts. The compounds have anti-depressant properties.Type: GrantFiled: January 13, 1981Date of Patent: June 29, 1982Assignee: UnivablotInventor: Jacques N. Astoin
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Patent number: 4334067Abstract: A flavan compound represented by the formula (I) ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined above, and the pharmaceutically acceptable acid addition salt thereof, which are useful as pharmaceutical agent having anti-convulsive, anti-ulcer, anti-arrythmic and diuretic activities.Type: GrantFiled: October 29, 1980Date of Patent: June 8, 1982Assignee: Maruko Seiyaku Co., Ltd.Inventors: Sachio Ohno, Mitsuaki Nagasaka, Kazuo Kato
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Patent number: 4328226Abstract: The present invention relates to the compounds having the following general formula (1) ##STR1## where: X is a halogen atomQ is a formyl or nitrile (cyano) groupY is a hydroxyl, alkoxyl, alkyl or nitro group"m" is the number of Y substituents 0 or 1"n" equals 1-20U and T are methyl radicals or hydrogen atoms acting strongly towards pathogenic fungi, especially of the Alternaria and Botrytis genera.Type: GrantFiled: April 3, 1980Date of Patent: May 4, 1982Assignee: Instytut Przemyslu Organicznego & Politechnika WroclawskaInventors: Stanislaw Witek, Damian Grobelny, Jadwiga Gorska-Poczopko, Edmund Bakuniak, Irena Bakuniak, Janina Ptaszkowska
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Patent number: 4327092Abstract: Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;Y is a saturated heterocyclic amino group having 5-8 ring members; andR.sup.2 is substituted or unsubstituted thienylalkyl or furanylalkyl.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.Type: GrantFiled: April 29, 1981Date of Patent: April 27, 1982Assignee: Glaxo Group LimitedInventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis
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Patent number: 4327022Abstract: Aminoalkylnaphthols and esters thereof, useful as cardiotonic or antibacterial agents, are prepared from the corresponding RO-naphthalenealkylamines, certain of which are also useful as cardiotonic agents.Type: GrantFiled: August 1, 1979Date of Patent: April 27, 1982Assignee: Sterling Drug Inc.Inventor: Denis M. Bailey
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Patent number: 4324786Abstract: New pyrido[2,3-e]-as-triazine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each stand for a C.sub.1-20 alkylcarbonyl, halogenated (C.sub.1-4 alkyl)-carbonyl, C.sub.1-4 alkoxycarbonyl, benzoyl, phenyl-(C.sub.1-4 alkyl)-carbonyl or phenyl-(C.sub.2-4 alkenyl)-carbonyl group or a 5-10-membered mono- or bicyclic nitrogen-containing heterocyclic acid residue (preferably a pyridylcarbonyl group) containing optionally one or more additional nitrogen, oxygen and/or sulfur atoms in the heterocyclic ring, and optionally one or more identical or different substituents selected from the group consisting of halogen, C.sub.1-4 alkoxy, nitro and hydroxy are attached to the aromatic or heterocyclic rings, furthermore one of R.sup.1 and R.sup.2 may also stand for hydrogen atom, orR.sup.1 and R.sup.2 may form, together with the adjacent nitrogen atoms, a pyrazole-2,4 ring having optionally a C.sub.1-6 alkyl substituent in position 3, andR.sup.3 stands for hydrogen, halogen, C.sub.Type: GrantFiled: April 25, 1980Date of Patent: April 13, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Andras Messmer, Pal Benko, Gyorgy Hajos, Lujza Petocz, Ibolya Kosoczky, Peter Gorog
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Patent number: 4324894Abstract: Novel aminoisoquinoline derivatives of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sub.2 represents a hydrogen atom,R.sub.3 represents a hydrogen atom,R.sub.4 represents a morpholinyl group or a piperazinyl group substituted with a pyridyl group, andpharmaceutically acceptable acid addition salts and quaternary derivatives thereof have been prepared. The novel compounds exert narcosis potentiating effects.Type: GrantFiled: April 10, 1980Date of Patent: April 13, 1982Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Andras Gelleri, Gyorgy Hajos, Andras Messmer, Laszlo Pallos, Lujza Petocz, Ibolya Kosoczky, Katalin Grasser, Peter Gorog, Eniko Szirt nee Kiszelly
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Patent number: 4324897Abstract: The disclosed [[2-(substituted amino)-2-phenylethyl]-nitrosoamino]acetonitrile derivatives and the ring closed oxadiazolium salts thereof as well as their pharmaceutically acceptable acid addition salts are antihypertensive agents useful in the treatment of hypertension.Type: GrantFiled: May 18, 1981Date of Patent: April 13, 1982Assignee: American Home Products CorporationInventor: Reinhardt P. Stein
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Patent number: 4324893Abstract: 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.Type: GrantFiled: February 28, 1980Date of Patent: April 13, 1982Assignee: American Home Products CorporationInventors: Anthony C. Scotese, Arthur A. Santilli
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Patent number: 4322418Abstract: This invention relates to substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines in the racemic or optically active form and the non-toxic pharmacologically acceptable salts thereof. These compounds are useful in the promotion of blood circulation in warm-blooded animals.Type: GrantFiled: April 3, 1981Date of Patent: March 30, 1982Assignee: C. H. Boehringer SohnInventors: Walter Losel, Franz Esser, Otto Roos, Richard Reichl, Franz J. Kuhn, Werner Traunecker
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Patent number: 4322527Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl or C.sub.7 -C.sub.9 phenylalkyl and R.sub.2 is hydrogen or C.sub.1 -C.sub.18 alkyl, or, if R.sub.1 is hydrogen, R.sub.2 is a divalent 1,1,3,3,-tetramethylpropylene radical fused in the 2-position and 3-position or the 9-position and 10-position, and X is sulfur or a group --CH(R).sub.3 --, in which R.sub.3 is hydrogen or a radical of the formula II --CH(R.sub.4)--CH(R.sub.5)SR.sub.6, and each of R.sub.4 and R.sub.5 independently is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.6 is C.sub.1 -C.sub.20 alkyl, while the alkyl group can be interrupted by one or more sulfur atoms, and A is a primary or secondary aliphatic or alicyclic, aromatic or araliphatic amine which contains substituents of the same type or mixed substituents, or a heterocyclic amine or a hydrazine derivative. These compounds are useful stabilizers for organic material.Type: GrantFiled: May 5, 1980Date of Patent: March 30, 1982Assignee: Ciba-Geigy CorporationInventor: Michael Rasberger
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Patent number: 4321373Abstract: This invention relates to 2-hydroxy-3-naphthoic acid amides of the general formula: ##STR1## wherein R.sub.1 is hydrogen, a substituted or unsubstituted alkyl, cycloalkyl, aralkyl, or aryl group, and R.sub.2 and R.sub.3 are identical or different and are hydrogen, a substituted or unsubstituted alkyl, cycloalkyl, aralkyl, or aryl group, or, together with the nitrogen atom to which they are attached, a substituted or unsubstituted heterocyclic group. The compounds are useful as coupling components for diazo printing.Type: GrantFiled: August 29, 1980Date of Patent: March 23, 1982Assignee: Hoechst AktiengesellschaftInventor: Siegfried Scheler