Patents Examined by R. W. Ramsuer
  • Patent number: 5753695
    Abstract: The invention relates to a compound of formula (I) ##STR1## wherein X is a pharmacologically acceptable anion,R.sub.1 and R.sub.2 are independently of each other hydrogen, or an --OY group in which Y is hydrogen, an .alpha.-aminoacyl, or a C.sub.1-5 aminoalkyl residue,R.sub.3, R.sub.4 and R.sub.7 are independently of each other hydrogen, or a C.sub.1-5 alkyl residueR.sub.5 is hydrogen, and .alpha.-aminoacyl, or a C.sub.1-5 alkyl residue, andR.sub.6 is hydrogen, OH.sup.-, or a C.sub.1-5 alkyl residue,and pharmaceutically acceptable salts and esters thereof; and to condensation processes for preparing them.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: May 19, 1998
    Assignee: Biogal Gyogyszergyar RT
    Inventors: Gyorgy Sulyok, Janos Balint, Ildiko Borbely, Jolan Kiss, Ferenc D. Toth
  • Patent number: 5506254
    Abstract: Pyrazolyl derivatives of the general formula I ##STR1## where the indices and the substituents have the following meanings: n is is 0, 1, 2, 3 or 4, it being possible for the radicals R.sup.1 to be different if n is greater than 1;m is 0, 1 or 2, it being possible for the radicals R.sup.3 to be different if m is greater than 1;R.sup.1 is nitro, cyano, halogen,alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio,unsubstituted or substituted phenyl or phenoxy;R.sup.2 is hydrogen,unsubstituted or substituted alkyl, alkenyl or alkynyl,an unsubstituted or substituted, saturated or mono- or diunsaturated ring,an unsubstituted or substituted, mono- or binuclear aromatic radical;R.sup.3 is nitro, cyano, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy;R.sup.4 is hydrogen, cyano, halogen, alkyl or haloalkyl,processes for their preparation and their use are described.
    Type: Grant
    Filed: July 6, 1995
    Date of Patent: April 9, 1996
    Inventors: Reinhard Kirstgen, Hartmann Konig, Hubert Sauter, Volker Harries, Gisela Lorenz, Eberhard Ammermann
  • Patent number: 5470863
    Abstract: A description follows of oximic derivatives with a fungicide activity, for agricultural use, having the formula (I): ##STR1## wherein: A, B, D, are N, or .dbd.C--G;G is H, halogen, NO.sub.2, CN, --COOR.sub.4, C.sub.1 -C.sub.6 (halo)alkylR.sub.1, R.sub.2, R.sub.4 and R.sub.5, are C.sub.1 -C.sub.6 (halo)alkyl;R.sub.3 is H, C.sub.1 -C.sub.6 (halo)alkyl or --COOR.sub.5 ;W is C.sub.2 -C.sub.10 alkylene;L represents O or S;Y represents phenyl, naphthyl, heterocycle, substituted alkyl.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: November 28, 1995
    Assignees: Ministero Dell'Universita' E Della Ricerca Scientifica E Technologica
    Inventors: Giovanni Camaggi, Lucio Filippini, Marilena Gusmeroli, Giovanni Meazza, Giampaolo Zanardi, Carlo Garavaglia, Luigi Mirenna
  • Patent number: 4973587
    Abstract: Antiglaucoma compositions containing 3-aryl-carbonyl-1-aminoalkyl-1H-indoles, as the active component thereof, and a method of use thereof in the treatment of glaucoma.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: November 27, 1990
    Assignee: Sterling Drug Inc.
    Inventors: Susan J. Ward, Malcolm R. Bell
  • Patent number: 4892958
    Abstract: A process for the preparation of a 5-amino-1-phenyl-4-nitropyrazole of the formula ##STR1## in which Ar is optionally substituted phenyl, which comprises reacting an arylhydrazine of the formulaAr--NH--NH.sub.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: January 9, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventor: Hauke Furstenwerth
  • Patent number: 4775680
    Abstract: Cyclohept[b]indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.
    Type: Grant
    Filed: July 21, 1987
    Date of Patent: October 4, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John W. Gillard, Yvan Guindon, Howard E. Morton, Yves Girard
  • Patent number: 4379936
    Abstract: 3.alpha.-Benzoylamino-2.beta.-hydroxy-nortropanes substituted in the 8-position by an alkoxycarbonyl or alkanoyl group, useful as analgesics, are prepared by reacting the corresponding 2.beta.,3.beta.-epoxy-nortropane with benzylamine in the presence of phenol.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: April 12, 1983
    Assignee: Sterling Drug Inc.
    Inventor: Robert L. G. Clarke
  • Patent number: 4370347
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: January 25, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4337252
    Abstract: The compounds have the formula: ##STR1## in which R is OH, OCH.sub.3, OCH.sub.2 CH.dbd.CH.sub.2 or OCH.sub.2 --C.tbd.CH, or a halogen atom, as well as their addition salts. The compounds have anti-depressant properties.
    Type: Grant
    Filed: January 13, 1981
    Date of Patent: June 29, 1982
    Assignee: Univablot
    Inventor: Jacques N. Astoin
  • Patent number: 4334067
    Abstract: A flavan compound represented by the formula (I) ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined above, and the pharmaceutically acceptable acid addition salt thereof, which are useful as pharmaceutical agent having anti-convulsive, anti-ulcer, anti-arrythmic and diuretic activities.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: June 8, 1982
    Assignee: Maruko Seiyaku Co., Ltd.
    Inventors: Sachio Ohno, Mitsuaki Nagasaka, Kazuo Kato
  • Patent number: 4328226
    Abstract: The present invention relates to the compounds having the following general formula (1) ##STR1## where: X is a halogen atomQ is a formyl or nitrile (cyano) groupY is a hydroxyl, alkoxyl, alkyl or nitro group"m" is the number of Y substituents 0 or 1"n" equals 1-20U and T are methyl radicals or hydrogen atoms acting strongly towards pathogenic fungi, especially of the Alternaria and Botrytis genera.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: May 4, 1982
    Assignee: Instytut Przemyslu Organicznego & Politechnika Wroclawska
    Inventors: Stanislaw Witek, Damian Grobelny, Jadwiga Gorska-Poczopko, Edmund Bakuniak, Irena Bakuniak, Janina Ptaszkowska
  • Patent number: 4327092
    Abstract: Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;Y is a saturated heterocyclic amino group having 5-8 ring members; andR.sup.2 is substituted or unsubstituted thienylalkyl or furanylalkyl.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.
    Type: Grant
    Filed: April 29, 1981
    Date of Patent: April 27, 1982
    Assignee: Glaxo Group Limited
    Inventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis
  • Patent number: 4327022
    Abstract: Aminoalkylnaphthols and esters thereof, useful as cardiotonic or antibacterial agents, are prepared from the corresponding RO-naphthalenealkylamines, certain of which are also useful as cardiotonic agents.
    Type: Grant
    Filed: August 1, 1979
    Date of Patent: April 27, 1982
    Assignee: Sterling Drug Inc.
    Inventor: Denis M. Bailey
  • Patent number: 4324893
    Abstract: 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: April 13, 1982
    Assignee: American Home Products Corporation
    Inventors: Anthony C. Scotese, Arthur A. Santilli
  • Patent number: 4324894
    Abstract: Novel aminoisoquinoline derivatives of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sub.2 represents a hydrogen atom,R.sub.3 represents a hydrogen atom,R.sub.4 represents a morpholinyl group or a piperazinyl group substituted with a pyridyl group, andpharmaceutically acceptable acid addition salts and quaternary derivatives thereof have been prepared. The novel compounds exert narcosis potentiating effects.
    Type: Grant
    Filed: April 10, 1980
    Date of Patent: April 13, 1982
    Assignee: Egyt Gyogyszervegyeszeti Gyar
    Inventors: Pal Benko, Andras Gelleri, Gyorgy Hajos, Andras Messmer, Laszlo Pallos, Lujza Petocz, Ibolya Kosoczky, Katalin Grasser, Peter Gorog, Eniko Szirt nee Kiszelly
  • Patent number: 4324897
    Abstract: The disclosed [[2-(substituted amino)-2-phenylethyl]-nitrosoamino]acetonitrile derivatives and the ring closed oxadiazolium salts thereof as well as their pharmaceutically acceptable acid addition salts are antihypertensive agents useful in the treatment of hypertension.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: April 13, 1982
    Assignee: American Home Products Corporation
    Inventor: Reinhardt P. Stein
  • Patent number: 4324786
    Abstract: New pyrido[2,3-e]-as-triazine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each stand for a C.sub.1-20 alkylcarbonyl, halogenated (C.sub.1-4 alkyl)-carbonyl, C.sub.1-4 alkoxycarbonyl, benzoyl, phenyl-(C.sub.1-4 alkyl)-carbonyl or phenyl-(C.sub.2-4 alkenyl)-carbonyl group or a 5-10-membered mono- or bicyclic nitrogen-containing heterocyclic acid residue (preferably a pyridylcarbonyl group) containing optionally one or more additional nitrogen, oxygen and/or sulfur atoms in the heterocyclic ring, and optionally one or more identical or different substituents selected from the group consisting of halogen, C.sub.1-4 alkoxy, nitro and hydroxy are attached to the aromatic or heterocyclic rings, furthermore one of R.sup.1 and R.sup.2 may also stand for hydrogen atom, orR.sup.1 and R.sup.2 may form, together with the adjacent nitrogen atoms, a pyrazole-2,4 ring having optionally a C.sub.1-6 alkyl substituent in position 3, andR.sup.3 stands for hydrogen, halogen, C.sub.
    Type: Grant
    Filed: April 25, 1980
    Date of Patent: April 13, 1982
    Assignee: Egyt Gyogyszervegyeszeti Gyar
    Inventors: Andras Messmer, Pal Benko, Gyorgy Hajos, Lujza Petocz, Ibolya Kosoczky, Peter Gorog
  • Patent number: 4322527
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl or C.sub.7 -C.sub.9 phenylalkyl and R.sub.2 is hydrogen or C.sub.1 -C.sub.18 alkyl, or, if R.sub.1 is hydrogen, R.sub.2 is a divalent 1,1,3,3,-tetramethylpropylene radical fused in the 2-position and 3-position or the 9-position and 10-position, and X is sulfur or a group --CH(R).sub.3 --, in which R.sub.3 is hydrogen or a radical of the formula II --CH(R.sub.4)--CH(R.sub.5)SR.sub.6, and each of R.sub.4 and R.sub.5 independently is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.6 is C.sub.1 -C.sub.20 alkyl, while the alkyl group can be interrupted by one or more sulfur atoms, and A is a primary or secondary aliphatic or alicyclic, aromatic or araliphatic amine which contains substituents of the same type or mixed substituents, or a heterocyclic amine or a hydrazine derivative. These compounds are useful stabilizers for organic material.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: March 30, 1982
    Assignee: Ciba-Geigy Corporation
    Inventor: Michael Rasberger
  • Patent number: 4322418
    Abstract: This invention relates to substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines in the racemic or optically active form and the non-toxic pharmacologically acceptable salts thereof. These compounds are useful in the promotion of blood circulation in warm-blooded animals.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: March 30, 1982
    Assignee: C. H. Boehringer Sohn
    Inventors: Walter Losel, Franz Esser, Otto Roos, Richard Reichl, Franz J. Kuhn, Werner Traunecker
  • Patent number: 4321269
    Abstract: The compounds are 1-(3-halo-1,2-dioxopropyl)-cycloamines, eg 1-(3-chloro-1,2-dioxopropyl)-piperidine, and are useful as fungicides and bactericides. They can be prepared by halogenation of a corresponding 1-(1,2-dioxopropyl)-cycloamine.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: March 23, 1982
    Assignee: Sandoz, Inc.
    Inventor: James R. Wareing