Patents Examined by R. Waller
  • Sulfonylamino phenylacetamide derivatives and methods of their use
    Patent number: 6992193
    Abstract: Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds of the invention that, preferably: (1) bind with high affinity to ? opioid receptors; (2) display good opioid receptor selectivity of ? versus ? and ? versus ?; and (3) do not substantially inhibit cytochrome P450 enzymatic activity, in particular CYP2D6, CYP2C9 and CYP3A4.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: January 31, 2006
    Assignee: Adolor Corporation
    Inventors: Bertrand Le Bourdonnec, Christopher William Ajello, Roland E. Dolle
  • Process for preparing glycidylphthalimide
    Patent number: 6875875
    Abstract: A process for preparing glycidylphtalimide or it optically active compound by reacting a phthalimide alkalimetal salt with an epihalohydrin or an optically active epihalohydrin in an alcohol solvent; or by reacting phthalimide with an epihalohydrin or an optically active epihalohydrin in the presence of an alkali metal carbonate, an alkali metal hydrogencarbonate or a quaternary ammonium salt to obtain a N-(3-halogeno-2-hydroxypropyl)phthalimide and then by cyclizing the product with an alkali metal alkoxide.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: April 5, 2005
    Assignee: Daiso Co., Ltd.
    Inventors: Yoshiro Furukawa, Yasushi Miki