Patents Examined by Rachael E Bredefeld
  • Patent number: 10799593
    Abstract: The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc. The present invention also provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: October 13, 2020
    Assignee: Northwestern University
    Inventors: Dean Ho, Mark Chen, Erik Pierstorff, Erik Robinson, Robert Lam, Rafael Shimkunas, Xueqing Zhang, Houjin Huang
  • Patent number: 10799389
    Abstract: A mouthpiece device for the use with the treatment of obstructive sleep apnea syndrome includes at least one main air channel provided at the outlet of the mouth, at least one side air channel provided at the outlet of mouth, at least one one way valve placed inside the main air channel, at least one protective plane arranged between the inner part of the lips and the outer surface of the teeth, at least one palate chamber extending inside the mouth, at least one tongue chamber placed inside the palate chamber, at least one vent provided on the tongue chamber, at least one sensor for measuring the carbon dioxide and oxygen levels in the air exhaled by the patient, at least one palate extension extending from the palate chamber towards the soft palate, and electrically stimulates the palate when the sensor detects that the patient stops breathing.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: October 13, 2020
    Inventors: Sefa Zulfikar, Ozgur Kocaturk, Albert Guvenis
  • Patent number: 10786386
    Abstract: A medical body position retaining belt securing device is disclosed. The medical body position retaining belt securing device for securing and releasing a medical body position retaining belt to and from an operating table side guide rail, comprising an upper clamping piece, a lower clamping piece and an elastic piece, the upper clamping piece or the lower clamping piece being coupled to the medical body position retaining belt, each of the upper clamping piece and the lower clamping piece including a clamping portion for clamping the operating table side guide rail, and two ends of the elastic piece respectively abutting against or being secured to the upper clamping piece and the lower clamping piece.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: September 29, 2020
    Assignee: Maquet (Suzhou) Co., Ltd.
    Inventors: Xiaowang Tao, Wei Peng, Qingxue Li, Hongqiang Li, Ming Ji
  • Patent number: 10786384
    Abstract: A shoulder brace can be fitted to a patient having an externally injured shoulder in the initial stage of treatment and which enables the patient to make motions in directions suitable for early rehabilitation exercises for the injured shoulder. The shoulder brace is fitted to the patient having the externally injured shoulder in a physiological reference position where the elbow joint of the patient is flexed by an angle of 90° in the frontward direction and the shoulder is internally rotated by an angle of 30°.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: September 29, 2020
    Inventor: Shin-ichi Nakamitsu
  • Patent number: 10779994
    Abstract: Compression device (1) for application circumferentially around a patient's limb (10), comprising a) a first band portion (20a) and a second band portion (20b), both band portions (20) being arrangeable along at least a part of the circumference of the limb for creating radial pressure on the limb, b) a spine element (30), extending in axial direction (100) when the compression device is applied around the limb, and comprising a first and a second guide opening (40a, 40b) for guiding the first and the second band portions, respectively. The guide openings (40a, 40b) are arranged offset in axial direction with respect to each other such that, when the first band portion is arranged along at least a part of the circumference of the limb and guided through the first guide opening, and the second band portion is arranged along at least a part of the circumference of the limb, parallel to the first band portion, and guided through the second guide opening, the band portions overlap in an axial direction.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: September 22, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Guido Hitschmann, Tim Jaeger, Magdalena R. Jüngst, Berenike I. Sauer
  • Patent number: 10780143
    Abstract: Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: September 22, 2020
    Inventors: Yumei Feng Earley, Tianxin Yang
  • Patent number: 10774118
    Abstract: The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: September 15, 2020
    Assignee: The Regents of the University of California
    Inventors: John K. Bielicki, Jan Johansson, Waleed Danho
  • Patent number: 10772966
    Abstract: Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: September 15, 2020
    Assignee: OPHIDION INC.
    Inventor: Andreas Walz
  • Patent number: 10772927
    Abstract: The present invention relates to the use of a casein hydrolysate as an antiviral agent for the treatment of opportunistic virus infections, especially herpesvirus and human papillomavirus. This casein hydrolysate has an application in both the therapeutic treatment of established symptoms and the prevention of the infection or the reactivation of a latent infection by an opportunistic virus. The casein hydrolysate of the present invention is effective for the prevention of opportunistic virus infections in individuals with weakened immune system.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: September 15, 2020
    Assignee: NTD Labs, S.L.
    Inventors: Pere Adell Winkler, Guillermo Lopez Zarco
  • Patent number: 10775393
    Abstract: Disclosed is a reagent for prothrombin time measurement, wherein the reagent contains a liposome composition containing a first liposome having a phospholipid layer, a second liposome having a phospholipid layer of a different composition from that of the first liposome, and tissue factor, wherein the tissue factor is associated with the phospholipid layer of at least one of the first liposome and the second liposome; the first liposome contains a phosphatidylcholine compound, a phosphatidylethanolamine compound, and a phosphatidylserine compound; and the second liposome contains at least one phospholipid selected from the group consisting of a phosphatidylcholine compound and a phosphatidylethanolamine compound.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: September 15, 2020
    Inventors: Yusuke Tanaka, Takahiko Bando, Kiyoko Kohama, Haruki Yamaguchi
  • Patent number: 10765561
    Abstract: Embodiments disclosed herein are directed to the treatment of wounds using negative pressure. Some embodiments disclosed herein provide for a foam pad, which may be suitable for use in abdominal wound sites, and which may be sized in a dimensionally-independent manner. Additional embodiments provide for a wound contact layer, as well as a system for the treatment of abdominal wounds.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: September 8, 2020
    Assignee: Smith & Nephew, Inc.
    Inventors: James D. Lattimore, Michael B. Mosholder
  • Patent number: 10758422
    Abstract: A bandaging system relating to assisting improved wound compression, wound stability, and wound-management of wound sites and other wound care.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: September 1, 2020
    Assignee: FIELD TO FIELD, INC.
    Inventor: Kim L. Shipe
  • Patent number: 10745458
    Abstract: An insulin analogue comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid substitutions at positions A8, B28, and/or B29. A proinsulin analogue or single-chain insulin analogue contains a B domain containing a cyclohexanylalanine substitution at position B24 and optionally contains additional amino-acid substitutions at positions A8, B28, and/or B29. The analogue may be an analogue of a mammalian insulin, such as human insulin. A nucleic acid encoding such an insulin analogue is also provided. A method of lowering the blood sugar of a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. A method of semi-synthesis using an unprotected octapeptide by means of modification of an endogenous tryptic site by non-standard amino-acid substitutions.
    Type: Grant
    Filed: November 22, 2018
    Date of Patent: August 18, 2020
    Assignee: Case Western Reserve University
    Inventor: Michael A. Weiss
  • Patent number: 10745457
    Abstract: A process for solubilization and refolding of precursor insulin or insulin analogs from inclusion body isolates for use in the production of insulin or insulin analog is described.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: August 18, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Allison D. Ortigosa, Rebecca A. Chmielowski, Mark C. Sleevi
  • Patent number: 10738055
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 11, 2020
    Assignee: The Broad Institute, Inc.
    Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
  • Patent number: 10738080
    Abstract: Provided herein are compounds that inhibit a binding interaction between a ? integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 11, 2020
    Inventor: Xiaoping Du
  • Patent number: 10722477
    Abstract: The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-alkyl-phosphinoyl-alkanes as described herein, DIPA-1-8 and DIPA-1-9, and 2-6 and 2-7 that are collectively referred to herein as “DAPA compounds”, that are useful in the treatment of disorders (e.g., diseases) including: sensory discomfort (e.g., caused by inflammation, irritation, itch, or pain) in the nasal cavity. The applicant has found that localized delivery of DAPA compounds in combination with an intranasal steroid or an intranasal antihistamine immediately relieves nasal discomfort and enhances patient adherence to the use of the nasal medications.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: July 28, 2020
    Inventor: Edward Tak Wei
  • Patent number: 10722608
    Abstract: The present disclosure is directed to blood dotting compositions comprising platelet microparticles, method of using said compositions, and methods of preparing the same.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 28, 2020
    Assignee: University of Rochester
    Inventor: Majed A. Refaai
  • Patent number: 10709655
    Abstract: The present invention provides a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: July 14, 2020
    Inventors: Artur Manuel Cavaco Paulo, Celia Freitas Da Cruz, Margarida Maria Macedo Francesko Fernandes
  • Patent number: 10709734
    Abstract: The present application discloses a method of synthesizing metal-based cationic surfactants and further their usage as anti-tumor and anti-bacterial agents. For the synthesis, selenius acid is mixed with sulfonamide to form sulfonammonium hydrogen selenites. Cobalt and Platinum hydrogen selenite dehydrate were then synthesized, and refluxed with sulfonammonium hydrogen selenites to form the disclosed Cobalt/Platinum ammonium hydrogen selenite complexes. Both complexes were mixed with cyclodextrin oligosaccharide to form nanoparticles, which were tested for anti-tumor/cancer and anti-bacterial effects.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: July 14, 2020
    Assignee: Umm-Al-Qura University
    Inventors: Manal Mohamed khowdiary, Nashwa Mostafa Saleh