Abstract: This invention is based on the observed oxidative stress and increased risk on cardiovascular diseases in subjects with increased lipid peroxidation, in particular with women using oral contraceptives and in hormone replacement therapies. The invention provides compositions and combinations, particularly useful in preventing and or reducing the increased lipid peroxidation in subjects in need thereof. These compositions are based on the synergistic combination of zinc and/or a hydroxyl radical scavenger in reducing lipid peroxidation.

Abstract: Self-heating non-aerosol shave products are provided. In some implementations, the shave product includes a non-ionic emulsifier system, for example, including one or more fatty alcohol ethoxylates.

Abstract: The present disclosure relates to a cosmetic composition for the care of keratin materials and which comprises, in an aqueous medium: at least one silicone, at least one mono- or diester of a fatty acid and of ethylene glycol or of polyethylene glycol, and at least one ester of a C8 to C14 fatty acid and of an oxyethylenated sorbitan comprising from 2 to 10 oxyethylene units. The present disclosure also relates to a process for the cosmetic treatment of keratin materials using the composition.

Abstract: Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives, and a coating. The coating may include from about 5% to about 99% by weight of the coating of a pharmaceutically acceptable pH-independent polymer. The coating may further include from about 0.001% to about 30% by weight of the coating of a surfactant. In another aspect, the invention provides methods for preparing and administering a pharmaceutical composition in oral dosage form, such as a tablet.

Abstract: Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.

Abstract: The present invention is directed to heat treated xanthan gums, which have improved solution viscosity over other xanthan gums heat-treated under the same processing conditions while maintaining the improved ease of use and the short, non-stringy gel texture of heat treated xanthan gums. Such high solution viscosity xanthan gums are suitable in a variety of applications, including cosmetic and personal care compositions.

Abstract: The invention relates to a polymer matrix suitable for the transdermal administration of rotigotine [(?)-5, 6, 7, 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphtol], containing a matrix for the transdermal administration of rotigotine [(?)-5, 6, 7, 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1 naphtol], containing a matrix polymer which is supersaturated with a rotigotine base. Said polymer matrix is characterised in that the part of the rotigotine which is not dissolved in the matrix polymer is dispersed in the matrix polymer as amorphous particles having a maximum mean diameter of 30 ?m, and the matrix is free of solubilisers, crystallisation inhibitors and dispersants. The invention also relates to a flat device for the transdermal administration of rotigotine, containing the above-mentioned, preferably silicon-based polymer matrix which is supersaturated with rotigotine, and a rear layer which is impermeable to the active ingredient.

Abstract: A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is ? times by mass to 4 times by mass as that of the rosin-based resin.

Abstract: Disclosed is a package for a personal care composition, the package comprising a container containing a personal care composition, the container having a base comprising a base face for standing the package on a planar surface, and a cap removably connected to and covering a dispensing end of the container opposite to the base. The cap has an end face which is inclined to the base face, and the container and cap are shaped to permit the package, independent of the amount of the personal care composition contained within the container, selectively to be stood on the base face in an upright orientation on the planar surface or on the end face in an inverted orientation on the planar surface.

Abstract: A low pH composition containing a retinol and a method for treating skin is disclosed. The composition contains (a) a retinoid and (b) an active acid, like an alpha-hydroxy acid or a beta-hydroxy acid, and has a pH of less than 5.

Abstract: A prophylactic (prophy) paste composition comprising about 40 percent by weight to about 55 percent by weight expanded perlite comprising perlite granules in the range of about 20 ?m to about 70 ?m and floaters. The prophy paste composition further comprises no more than 5 percent by weight of a surfactant, and greater than about 10 percent by weight water. In some embodiments, the inventive paste also contains a humectant and optionally, may contain coloring agents, preservative agents, alcohol, flavoring agents, viscosity increasing agents, and sodium fluoride. The present invention also provides methods for controlling the floater content of the expanded perlite used in the inventive paste and methods of packaging the expanded perlite paste composition in a tube. The present invention also provides a prophy paste product comprising the inventive prophy paste contained within a squeezable tube.

Abstract: A quickly dissolving carrier granule made up of wood fibers, mineral filler, and starch-based or dextrin-based adhesive binder. The wood fibers in these granules are preferably wood fibers ranging from about 10 microns to about 2 mm in length. Typically, at least about 35 weight- % of the fibers are retained on a 50-Mesh U.S. Sieve Series screen. The wood fibers in this invention are derived from sources that are substantially free of resins such as urea-formaldehyde resin and of diphenylmethane diisocyanate resin. Typical binders are soluble dextrin binders or a viscous corn starch, wheat starch, rice starch, tapioca starch, potato starch, or sago starch binders. The granules have a Resistance to Attrition of at least 90%. Also disclosed is a method of making such granules.

Abstract: The present invention is related to materials and methods for forming polymeric delivery vehicles that reduces risk of oxidative degradation of a carried drug and the resulting compositions.

Abstract: A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.

Abstract: Personal care or cosmetic oil in water emulsions include an oil emulsifier and a combination of a Xanthan polysaccharide and a polyglucomannan polysaccharide to provide enhanced stability even at low emulsifier stabilizer levels. The emulsifier stabilizer system provides stable emulsions without dominating system rheology, particularly viscosity. Thus, the emulsions can have a low viscosity suitable for formulation as milks or thin lotions, or can be thickened, desirably by thickening agents other than the Xanthans and/or polyglucomannan, to provide emulsion creams or gels. This enables the system to be used very flexibly in end use applications. The emulsifier is desirably a non-ionic emulsifier and particularly is a combination of a low HLB and a high HLB emulsifier and can be formulated with conventional alcohol ethoxylate surfactants or from non-EO surfactants e.g. sucrose ester high HLB surfactants and citrate or sorbitan ester low HLB surfactants.

Abstract: To provide a cosmetic composition and a hair wash which are excellent in metal pyrithione salt persistence after washing with a washing liquid containing a surfactant, etc. A cosmetic composition and a hair wash, which comprise a copolymer and a metal pyrithione salt, wherein the copolymer contains constituting units corresponding to a cationic vinyl monomer of a specific structure and constituting units corresponding to a nonionic vinyl monomer of a specific structure.

Abstract: A transdermally absorbable preparation that even when a drug with poor solubility in a base is added in high concentration, is stable over time and can suppress crystallization of the drug, excelling in transdermal absorbability. There is provided a transdermally absorbable preparation, comprising a base and, added thereto, at least composite particles which are composed of a silicate compound and an organic acid and a drug.

Abstract: Phenyl boric acid and its salts and substituent derivatives (e.g., substituted phenyl) effectively inhibit the growth of several cancer cell lines and offers utility in the treatment/prevention of cancer. The material may be applied or injected into affected areas or applied topically, especially for the treatment of cervical cancer.

Abstract: Described are compositions and methods for imparting a sunless tan with functionalized adjuvants and a tanning agent like dihydroxyacetone. The functionalized adjuvants are pyrrole and/or indole derivatives functionalized with a substituent comprising a carbonyl group.

Abstract: The invention refers to the use of a mixture of naringin, bitter orange extract and sepiolite to improve ruminal fermentation in ruminants.