Abstract: The invention relates to compositions of vault complexes for use as delivery agents for hydrophobic and/or aqueous insoluble therapeutic compounds. In one aspect, provided herein is a vault complex comprising a modified major vault protein (MVP), wherein the modified major vault protein comprises a fusion peptide, wherein said fusion peptide is fused to the N-terminus of the major vault protein, and wherein said peptide provides enhanced sequestering of a hydrophobic and/or aqueous insoluble therapeutic compound within the vault complex.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
June 9, 2020
Assignee:
The Regents of the University of California
Inventors:
Leonard H. Rome, Daniel Buehler, Heather D. Maynard
Abstract: Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer.
Type:
Grant
Filed:
July 19, 2013
Date of Patent:
June 9, 2020
Assignee:
Impact Therapeutics, Inc.
Inventors:
Suixiong Cai, Ye Edward Tian, Sishun Kang, Zheng Meng, Chengyun Gu, Feng Yin, Shengzhi Chen, Yang Zhang, Xiuyan Zhang, Hongqiang Fei, Dongmei Wang
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for interleukin-6, and provides an IL-6 binding polypeptide comprising the sequence EEX3X4AWX7EIH X11 LPNLX16X17X18QX20 X21AFIX25X26LX28X29. The present disclosure also relates to the use of such an IL-6 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
Abstract: Shell-structured particles for sunscreen applications are provided herein. A method includes selecting one or more particles to serve as a core material in a sunscreen composition, wherein each of the one or more particles comprises a band gap within a predetermined range, and wherein said selecting is based on a desired absorption spectrum of the sunscreen composition; coating the one or more particles with at least one layer of zinc oxide.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
May 26, 2020
Assignee:
International Business Machines Corporation
Inventors:
Talia S. Gershon, Yun Seog Lee, Ning Li, Devendra Sadana, Teodor K. Todorov
Abstract: Shell-structured particles for sunscreen applications are provided herein. A composition includes one or more zinc oxide particles constituting a core material in a sunscreen composition, one or more particles coating the one or more zinc oxide particles, wherein each of the one or more particles comprises a band gap within a predetermined range, and wherein said one or more particles are selected based on a desired absorption spectrum of the sunscreen composition, and an anti-reflective coating applied to the surface of the one or more particles coating the one or more zinc oxide particles.
Type:
Grant
Filed:
November 16, 2017
Date of Patent:
May 26, 2020
Assignee:
International Business Machines Corporation
Inventors:
Talia S. Gershon, Yun Seog Lee, Ning Li, Devendra Sadana, Teodor K. Todorov
Abstract: Shell-structured particles for sunscreen applications are provided herein. A method includes selecting one or more particles to serve as a core material in a sunscreen composition, wherein each of the one or more particles comprises a band gap within a predetermined range, and wherein said selecting is based on a desired absorption spectrum of the sunscreen composition; coating the one or more particles with at least one layer of zinc oxide.
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
May 19, 2020
Assignee:
International Business Machines Corporation
Inventors:
Talia S. Gershon, Yun Seog Lee, Ning Li, Devendra Sadana, Teodor K. Todorov
Abstract: Provided is a use of a recombinant human calcineurin B subunit (rhCNB) in the preparation of a medicine for killing and/or inhibiting the gastric cancer.
Abstract: A liquid preparation includes an etherified cyclodextrin derivative and a substituted benzimidazol, where the etherified cyclodextrin derivative is one of alpha-, beta, and gamma-cyclodextrin ether.
Abstract: The present invention relates to a composition that can be used as or as part of a wound dressing and to wound dressings comprising the same. More specifically, the present invention relates to a composition that disrupts and kills bacteria within a biofilm and also prevents biofilm formation. The composition comprises a fibrous first component selected from the group consisting of chitosan, chitin, derivatives of chitosan, derivatives of chitin, and combinations thereof; at least one triprotic acid and at least one solubilising acid.
Abstract: The present invention is concerned with the use of transition coating and transition coating composition to control and or target the release of active pharmaceutical ingredients, and biological, chemical, neutraceutical, agricultural and nutritional materials and a method of preparing controlled release systems utilizing these components.
Abstract: This document provides methods and materials related to treating liver conditions. For example, the methods and materials relating to the use of cAMP inhibitors to treat liver conditions are provided.
Type:
Grant
Filed:
November 30, 2016
Date of Patent:
April 21, 2020
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Nicholas F. LaRusso, Tetyana V. Masyuk, Melissa Muff-Luett
Abstract: A method of treating anxiety in a subject having a mutation in the lynx2 gene and suffering from anxiety, includes administering to the subject an effective amount of a nicotinic blocker and/or an effective amount of a selective antagonist of the nicotinic acetylcholine receptor alpha-7 (nAChR ?7) subunit.
Abstract: There are provided dicysteine peptide tags for use with dimaleimide fluorescent labelling agents for the labelling and detection of specific protein targets. Peptide tags comprising the amino acid sequence set forth in SEQ ID NO: 2 are described.
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
Type:
Grant
Filed:
November 20, 2017
Date of Patent:
March 3, 2020
Assignee:
Array BioPharma Inc.
Inventors:
Shenlin Huang, Xianming Jin, Zuosheng Liu, Daniel Poon, John Tellew, Yongqin Wan, Xing Wang, Yongping Xie
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
Type:
Grant
Filed:
November 20, 2017
Date of Patent:
February 25, 2020
Assignee:
Array BioPharma Inc.
Inventors:
Shenlin Huang, Xianming Jin, Zuosheng Liu, Daniel Poon, John Tellew, Yongqin Wan, Xing Wang, Yongping Xie
Abstract: Regulating the level of glucose in the blood of an animal comprising the consumption by the animal of a composition containing beta-casein, or providing the composition to the animal for consumption, where the beta-casein comprises at least 75% by weight beta-casein A2. Uses include managing the symptoms of hyperglycaemia and associated conditions including diabetes. The effect is both acute (post-exposure to the composition) and ongoing.
Type:
Grant
Filed:
August 22, 2014
Date of Patent:
February 25, 2020
Assignee:
THE A2 MILK COMPANY LIMITED
Inventors:
Andrew John Clarke, Malav Suchin Trivedi
Abstract: There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity in about 60 seconds forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active) applied with a taste-masking membrane comprising a combination of water-insoluble and gastrosoluble polymers release not less than about 60% of the dose is in the stomach in about 30 minutes, thus maximizing the probability of achieving bioequivalence to the reference IR product having rapid onset of action (short Tmax). A process for preparing such compositions for oral administration using conventional fluid-bed equipment and rotary tablet press is also disclosed.
Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
Type:
Grant
Filed:
August 19, 2016
Date of Patent:
February 25, 2020
Assignee:
Cliff-Cartwright Corporation
Inventors:
Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
February 25, 2020
Assignee:
The Board of Regents of the University of Texas System
Inventors:
Eric N. Olson, Rhonda S. Bassel-Duby, Catherine A. Makarewich, Benjamin R. Nelson