Patents Examined by Ralph J. Gitomer
  • Patent number: 11186826
    Abstract: An object of the present invention is to provide a cell population comprising mesenchymal cells having low cell aggregability, which is useful for intravenous administration of a cell preparation, and a method for producing the same, and a pharmaceutical composition comprising the cell population. Also provided are methods for producing a cell population comprising mesenchymal stem cells, the method comprising obtaining a cell population having the following cell characteristics (the cell population satisfies the relative expression level of COL11A1 gene to the expression level of SDHA gene of 6.0 or less and the relative expression level of COL16A1 gene to the expression level of SDHA gene of 1.5 or less).
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: November 30, 2021
    Assignee: KANEKA CORPORATION
    Inventors: Keita Ino, Yuta Kita
  • Patent number: 11179421
    Abstract: Systems and methods are provided to limit abdominal distension and alleviate uncomfortable side effects related to it—in patients treated in hydrocolonic preparation units. Systems may comprise a water delivery unit comprising a controllable water supply, configured to introduce water controllably into the patient's large intestine, a drainage configured to drain, by gravity, the introduced water with contents of the patient's large intestine and a controller. The drainage comprises a drainage pipe and sensor(s) such as camera(s) configured to continuously measure the amount of drained water drained by the drainage pipe. The controller is configured to control the water introduction with respect to the measured amount of drained water, keeping an amount of water retained in the patient below a specified water retention threshold to reduce uncomfortable side effects of abdominal distension.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: November 23, 2021
    Assignee: HyGIeaCare, Inc.
    Inventors: Gavriel David Meron, Mordechai Yehuda Frisch
  • Patent number: 11179420
    Abstract: An object of the present invention is to provide novel mesenchymal stem cells demonstrating superior therapeutic effects for various diseases, a novel pharmaceutical composition containing the mesenchymal stem cells, and methods for preparing these. The present invention provides mesenchymal stem cells expressing at least one cell surface marker selected from the group consisting of CD201, CD46, CD56, CD147 and CD165. The mesenchymal stem cells expressing such a specific marker are positive for CD29, CD73, CD90, CD105 and CD166, and maintain an undifferentiated state.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: November 23, 2021
    Assignee: ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Yoshifumi Ikeyama, Eiko Uno, Masayo Yumoto, Mihoko Yoshino, Xuan Trung Ngo, Hiroyuki Nishida, Akiko Uetani
  • Patent number: 11173181
    Abstract: Camel hump oil based herbal compositions and methods for preparing the herbal compositions for the treatment of multiple diseases, such as dermatological conditions, musculoskeletal conditions, and hair conditions. A method for extracting the camel hump oil from camel hump and a method of de-odorizing the extracted camel hump. The camel hump-oil based herbal composition includes camel hump oil, an herbal oil extract, a curing agent, and additives. The camel hump oil-based composition is topically applied.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: November 16, 2021
    Inventor: Nafiseh Nili
  • Patent number: 11172674
    Abstract: There is described a preservation solution for the preservation of cells, tissues and/or organs, said solution comprising: (i) water for injection; (ii) at least one saccharide; (iii) at least one component with pH buffer properties; (iv) optionally at least one component with calcium transport blocking properties or an anti-calcium action activity; (v) salicylic acid, in free form or in salt form, or aspirin; and (vi) glutamic acid, in free form or in salt form, or glutamine; provided that acetamide is absent and/or if aspirin is present glutamine is absent and if glutamine is present aspirin is absent.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: November 16, 2021
    Inventors: Terence Simon Corbitt, Malgosia Jarmolowicz, Clare Lankester, Jeremy Peter Alan Lodge, Oluseun Olarewaju, David John Potts
  • Patent number: 11166452
    Abstract: Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially lung tissue, through the use of an expandable accumulator to maintain a constant pressure within the lumen of the organ even during external pressure fluctuations due to, for example, flight. Systems and methods may include prolonging donor organ viability in storage through the use of an organ container that mimics the geometry and orientation of the organ in vivo.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: November 9, 2021
    Assignee: Paragonix Technologies, Inc.
    Inventors: Jared Alden Judson, Lisa Maria Anderson, William Edelman
  • Patent number: 11160816
    Abstract: Provided is a composition for the treatment and/or prevention of Alzheimer's disease having an improved therapeutic or prophylactic effect together with reduced side effects. This composition for the treatment and/or prevention of Alzheimer's disease contains at least one compound selected from the group consisting of glycerophosphocholine (G) and pharmaceutically acceptable salts thereof as a first active ingredient and at least one compound selected from the group consisting of herperidin (H), narirutin (N), and pharmaceutically acceptable salts thereof as a second active ingredient. This composition promotes remyelination, promotes the activity of ?-secretase, and also suppresses the expression of ?-secretase.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 2, 2021
    Assignee: GLOVIA COMPANY LIMITED
    Inventors: Hiroaki Asou, Hiroaki Murase
  • Patent number: 11160272
    Abstract: The present invention relates to the use of a medical grade honey based ingredient for the preparation of a composition for preserving human and/or animal tissue. In addition, the present invention relates to the use of a medical grade honey based ingredient for the preparation of a composition for preserving human and/or animal tissue through the promotion of angiogenesis.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: November 2, 2021
    Assignee: TRITICUM EXPLOITATIE B.V.
    Inventor: Josephus Petrus Lidwinus Postmes
  • Patent number: 11160840
    Abstract: The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1?, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 2, 2021
    Assignees: Industry-Academic Cooperation Foundation, Yonsei University, Cosmax NBT, Inc., Cosmax NS, Inc.
    Inventors: Jae Kwan Hwang, Jun Gon Yun, Mi Bo Kim, Chang Hee Kim, Joon Hyung Lee, Do Wan Kwon, Su Young Choi, Jin Hak Kim, Ji Hwan Jang, Jeong Ho Geum, Min Son Kweon
  • Patent number: 11160271
    Abstract: Disclosed are an anti-freezing agent for protecting a biological tissue from being damaged during a freezing treatment and a preparation method therefor. The method for preparing the anti-freezing agent involves mixing ethylene glycol, water and dimethylsulfoxide homogeneously to form a matrix, and then slowly adding sodium polyacrylate. The prepared anti-freezing agent is coated onto biological tissue during a freezing treatment such that damage to the biological tissue is reduced.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: November 2, 2021
    Assignee: TAIPEI VETERANS GENERAL HOSPITAL
    Inventors: Po Kuei Wu, Wei Ming Chen, Cheng Fong Chen, Jir You Wang, Wen Hai Wu
  • Patent number: 11154596
    Abstract: Provided herein are methods for use in safe and effective thrombolysis, e.g., in therapy for a potential stroke or acute myocardial infarction (“AMI”) at a maximum arterial patency rate with minimal associated hemorrhagic side effects.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: October 26, 2021
    Assignee: Thrombolytic Science, LLC
    Inventor: Victor Gurewich
  • Patent number: 11154065
    Abstract: A topical mosquito control product includes active and inert ingredients. The active ingredients include natural materials and may include soybean oil, citronella oil, peppermint oil, thyme oil, cinnamon oil and cedar wood oil. The inert ingredients include natural materials and may include shea, anise oil, basil oil, bee's wax, isopropyl alcohol, avocado oil, sunflower oil, turmeric, salt, ethyl ester and water.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: October 26, 2021
    Assignee: Penta 5 USA, LLC
    Inventors: R. Charles Murray, John Harlin
  • Patent number: 11154581
    Abstract: A composition and method for the prevention and/or improvement of dry eye syndrome, dryness of eye and/or stiff neck and shoulder, which contains bilberry fruit extract and is effective with less intake are provided. As one aspect of the present invention, the composition for the prevention or improvement of dry eye syndrome or dryness of eye contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, the composition for the prevention or improvement of stiff neck and shoulder contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, a composition for the prevention or improvement of dry eye syndrome, dryness of eye, and stiff neck and shoulder, contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, a method using a bilberry fruit extract for the improvement of stiff neck and shoulder is provided.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: October 26, 2021
    Assignee: TOKIWA PHYTOCHEMICAL CO., LTD.
    Inventor: Jinwei Yang
  • Patent number: 11147858
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating inflammatory disease, which contains, as an active ingredient, a Bacillus amyloliquefaciens GF423 strain, a superoxide dismutase high-producing Bacillus amyloliquefaciens GF424 mutant strain, a superoxide dismutase (SOD) derived from one of these strains, or both the strain and the SOD. The superoxide dismutase derived from the Bacillus amyloliquefaciens GF423 strain (KCTC 13222BP), which is the active ingredient of the present invention, effectively suppresses or degrades reactive oxygen species, and thus has the effect of fundamentally preventing the causes of inflammatory bowel disease caused by reactive oxygen species. Therefore, the composition of the present invention may be developed into various products, including excellent drugs and health functional foods for preventing or treating inflammatory bowel disease.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: October 19, 2021
    Assignee: GENOFOCUS, INC.
    Inventors: Do Young Yum, Jeong Hyun Kim, Jae Gu Pan, Eui Joong Kim, Ji Eun Kang
  • Patent number: 11140899
    Abstract: The invention relates to methods of plant enhancement comprising administration of a composition comprising microalgae biomass to improve seed germination rate, seed germination time, seedling emergence, seedling emergence time, seedling size, plant fresh weight, plant dry weight, utilization, fruit production, leaf production, leaf formation, leaf size, leaf area index, plant height, thatch height, plant health, plant resistance to salt stress, plant resistance to heat stress, plant resistance to heavy metal stress, plant resistance to drought, maturation time, yield, root length, root mass, color, insect damage, blossom end rot,-fruit quality, flowering, or sunburn.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: October 12, 2021
    Assignee: Heliae Development, LLC
    Inventors: Sandip Shinde, Manakandadas Mathilakathu Madathil, Michael Warner, Stephen Ventre, Laura Carney, Michael Miller, Ganapathy Chellapan, Jon Hansen, Michael Lamont
  • Patent number: 11129862
    Abstract: The present invention relates to compositions providing improved substantivity, comfort and/or feel to the eye upon application. The present invention further relates to compositions comprising a cellulose derivative in combination with tamarind seed extract and hyaluronic acid in ratios that mimic the physical properties of human tears on the eye.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: September 28, 2021
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Mingqi Bai, Kenneth T. Holeva
  • Patent number: 11129861
    Abstract: The present invention provides a composition containing, as active ingredients, Panax ginseng, Adenophora triphylla, Wolfiporia extensa, Rehmannia glutinosa, and Mel for an antitussive, expectorant, or anti-inflammatory action, and a composition for preventing, alleviating, or treating a respiratory disease. The present invention provides a compositions having excellent effects compared with an existing antitussive agent and expectorant agent. The compositions of the present invention are a naturally derived material and has little cytotoxicity, and thus is expected to be safely used as a medicine or food composition having antitussive, expectorant, and anti-inflammatory effects.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: September 28, 2021
    Assignee: OKCHUNDANG CO., LTD.
    Inventors: Seong Min Ku, Tae Hun Ku, Chul Jong Jung, Jeong Gyun Seo, Hye Ran Gong, Sae Kwang Ku, Seok Man Park, Ryong Kong, Xian Li, Gyung Yun Beik, Yoeng Eun Yu, Hee Jeong Ryu, Gyu Hyeon Kim
  • Patent number: 11123392
    Abstract: Disclosed herein is a traditional Chinese medicine composition for treating interstitial pulmonary fibrosis, which is prepared from 10-20 parts by weight of Radix salviae miltiorrhiza, 4-8 parts by weight of peach kernel, 2-4 parts by weight of hirudo, 5-15 parts by weight of Radix paeoniae rubra, 5-15 parts by weight of Radix ophiopogonis, 5-15 parts by weight of Chebulae fructus immaturus and 2-4 parts by weight of Oroxylum indicum (Linn.) Kurz. The invention also provides a method of preparing the composition.
    Type: Grant
    Filed: December 28, 2019
    Date of Patent: September 21, 2021
    Assignee: Jiangsu Traditional Chinese Medicine Research Institute
    Inventors: Qiyong Zhu, Qingling Xiao, Xiaoli Chen, Yeqing Zhang, Jianming Ju
  • Patent number: 11123396
    Abstract: The present disclosure discloses a herbal formulation in powdered dosage form, which is useful to enhance the physical endurance or strength in athletes. The disclosure also includes a method of preparation of the formulation, which involves the encapsulation of the natural ingredients in a natural matrix. The formulation comprises Moringa oleifera, Kaempferia parviflora and Punica granatum that are processed to obtain the product in powder form by encapsulation of the natural ingredients in a natural matrix. The formulation increased the nitrate and nitrite levels in serum and saliva in human and is useful to improve the general health of the athletes.
    Type: Grant
    Filed: August 19, 2017
    Date of Patent: September 21, 2021
    Assignee: Aurea Biolabs Private Limited
    Inventors: Sreeraj Gopi, Karthik Varma Ayiranazhi Covilakam, Joby Jacob
  • Patent number: 11123395
    Abstract: The invention relates to a tobacco leaf extract containing, relative to the total weight of the extract, at least 5 wt.-% proteins essentially free of molecules with a molecular mass of less than 10 kDa. The invention also relates to a pharmaceutical composition containing such an extract and to the use thereof in the treatment of tobacco addiction.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 21, 2021
    Assignee: NFL Biosciences
    Inventor: Bruno Lafont