Patents Examined by Randall L. Green
-
Patent number: 5538512Abstract: This invention relates to infusion catheters that are used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic or vasoocclusive agents to a target site (the target site being accessible by a tortuous path through the vasculature). In particular, the invention relates to flow-directed catheters which have been coated on their interior or exterior surfaces with a cross-linkable lubricious polymer and to the method of making those catheters. The invention also relates to the process of using the infusion catheter.Type: GrantFiled: July 8, 1994Date of Patent: July 23, 1996Inventors: Wendy J. Zenzon, Uriel H. Chee, Joseph C. Eder, Robert Hergenrother
-
Patent number: 5538510Abstract: An intravascular catheter comprises a length of flexible plastic tubing which, in turn, comprises an outer plastic layer and an inner plastic layer. The plastic materials of the outer and inner layers are different, and may be chemically bonded to each other. Advantages in catheter design are achieved.Type: GrantFiled: January 31, 1994Date of Patent: July 23, 1996Assignee: Cordis CorporationInventors: Carlos A. Fontirroche, Stephen J. Querns
-
Patent number: 5536241Abstract: Methods and devices for using nitric oxide (NO) to decrease or prevent the contraction of a smooth muscle in a non-respiratory-tract organ of an animal, the organ being one which contains or is surrounded by a biological fluid which is not blood, which method includes the step of introducing an effective amount of NO into the fluid.Type: GrantFiled: March 24, 1993Date of Patent: July 16, 1996Assignee: The General Hospital CorporationInventor: Warren M. Zapol
-
Patent number: 5536258Abstract: An antimicrobial tubing connector for medical procedures, especially for extracorporeal connections as in peritoneal dialysis and hemodialysis tubing sets. A male portion includes a central tube surrounded by a sleeve radially spaced apart from the central tube to define an annular space. A mating female portion includes a tubular body which receives the central tube of the male portion and which is received by the annular space. A set of O-ring seals and mating threads produces a secure fluid-tight connection. An antimicrobial agent such as silver is deposited on one or more of several surfaces, preferably by a durable process such as ion assisted deposition, to prevent touch contamination. Either or both of the male and female portions may be capped with a separate cap, which may also receive the antimicrobial agent.Type: GrantFiled: February 14, 1994Date of Patent: July 16, 1996Assignee: Fresenius USA, Inc.Inventor: Thomas I. Folden
-
Patent number: 5536262Abstract: A medical coupling device is provided which is used for transferring fluid between a first reservoir and a second reservoir having a slit-less diaphragm. The device includes a connector having a port and a blunt cannula in fluid communication with the port. The cannula is adapted to puncture the diaphragm on the second reservoir and thereby facilitate the transfer of fluid between the first reservoir and the second reservoir. The cannula can be a hollow tube having an end which is substantially perpendicular to an axis extending longitudinally through the tube. The device may further include a shroud of a predetermined configuration associated with the connector. The shroud defines a recess for receiving the reservoir and inhibits inadvertent contact with the cannula which extends within the recess. The shroud defines a suction opening which tends to inhibit the formation of an undesirable suction upon removal of the reservoir.Type: GrantFiled: September 7, 1994Date of Patent: July 16, 1996Assignee: Cedars-Sinai Medical CenterInventor: Gustavo G. Velasquez
-
Patent number: 5536243Abstract: A self-contained time-release artificial insemination device which introduces a bolus of semen into the cervical canal or uterus over a period of hours is disclosed. The device includes a cervical cap adapted to conform and adhere to the cervix and includes an elongated nipple that extends in a perpendicular direction from the cap for insertion into the cervical canal or uterus. A time-release mechanism is provided in communication with the nipple for delivering semen through the nipple and includes a tubular body which defines a semen chamber and expansion chamber. A plunger is slidably mounted in the tubular member for separating the semen and expansion chambers. A reservoir is provided in communication with the expansion chamber for providing a quantity of fluid thereto, and a sealable aperture is provided for withdrawing and introducing fluids to both the reservoir and expansion chamber.Type: GrantFiled: December 13, 1994Date of Patent: July 16, 1996Inventor: Rajasingam S. Jeyendran
-
Patent number: 5536263Abstract: A non-occlusive medication patch to be applied to the skin includes a porous self-supporting backing layer to give the patch the required integrity and strength by acting as a supporting framework for other components, and a flexible hydrophilic pressure-sensitive adhesive reservoir comprising a hydrocolloidal gel for the sustained release of medication to be absorbed topically through the skin into the body of a patient. The reservoir has two portions: first, an external coating layer with an exposed lower skin-contacting surface that forms a pressure-sensitive bond with the skin, and second, an upper internal portion which infiltrates the porous backing and becomes solidified therein after being applied so that the reservoir and the backing are unified, enabling the backing itself to act as a storage location for the medication-containing reservoir.Type: GrantFiled: March 30, 1994Date of Patent: July 16, 1996Assignee: Lectec CorporationInventors: David Rolf, Elisabeth K. S. Urmann
-
Patent number: 5533526Abstract: An apparatus and method of use for treating carpal tunnel syndrome designed to permit delivery of a sustained release, depot form of a corticosteroid agent at an adequate therapeutic dosage, directly into the center of the carpal tunnel. The apparatus consists of an armboard adapted for receiving and securing a human forearm and hand. In a preferred embodiment, the armboard also includes at least one forearm bracket and at least one wrist bracket having an integrally formed centering pointer and needle guide for delivery of medication into the carpal tunnel. In one embodiment of the method of use, an anesthetic agent and a corticosteroid are delivered by a needle installation directly into the anatomic center of the carpal tunnel in order to produce the desired pharmacological effects.Type: GrantFiled: February 23, 1995Date of Patent: July 9, 1996Assignee: Goldberg's United Service CompanyInventor: Larry H. Goldberg
-
Patent number: 5533996Abstract: A connector assembly is provided having a male component (12) and a female component (10) to provide fluid communication between a fluid source and a destination such as a patient. The female component (10) includes a door (28) rotatable about a hinge (30). The door (28) is forced open by a longitudinal member (34) within the male component (12). The door (28) is converted into a position parallel to the length of the female component (10) providing fluid communication between a tubing (36) extending into the female component (10). A sleeve (44) is further provided to permit and to prevent fluid flow through a tubing by rotation of the sleeve (44) resulting in compression and expansion of longitudinal members (46) within the sleeve (44) and thereby the tubing.Type: GrantFiled: August 24, 1994Date of Patent: July 9, 1996Assignee: Baxter International, Inc.Inventors: Randy Murphey, Marc Bellotti, Ying-Cheng Lo, Scott Edwards
-
Patent number: 5533995Abstract: A transdermal device for the controlled administration of a drug to the skin comprises a reservoir (12) for the drug and an electric circuit which includes an electrode system (13, 14) which is operable to actively transport the drug in a controlled manner from the reservoir (12) towards the skin for transport therethrough, the skin not being part of the electric circuit, and the drug passing through an electrode (13) of said electrode system (13, 14) during the active transport to the skin. The electrode (13) is disposed between the reservoir (12) for the drug and an optional transit chamber (15). The electrode (13) can be permeable to the drug or the electrode can function as a gate, being permeable to the drug in the open condition and less permeable to the drug in the closed condition. The operation of the gate can be determined by the composition or the structure of the electrode (13). The device achieves drug delivery rates comparable to those achieved with iontophoretic devices.Type: GrantFiled: May 13, 1994Date of Patent: July 9, 1996Assignee: Elan Corporation, plcInventors: John Corish, Owen I. Corrigan
-
Patent number: 5533973Abstract: An apparatus and method are disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply to a feeding tube delivering the modified liquid enteral nutritional product to the gastrointestinal tract of a patient. At least one beneficial agent not in controlled release dosage form in a useful, dose unit, amount, is disposed within a formulation chamber so as to be taken up in a liquid enteral nutritional product traversing the formulation chamber while feeding the modified nutritional product into the gastrointestinal tract of a patient. The beneficial additive(s) are selected from nutrients, medicaments, probiotics, or diagnostic agents, or mixtures thereof, each in a dosage form that is dispersible in the medium of the liquid enteral nutritional product in less than two hours.Type: GrantFiled: January 13, 1995Date of Patent: July 9, 1996Assignee: Abbott LaboratoriesInventors: Carl J. Piontek, Terrence B. Mazer, Joseph E. Walton, Ronita K. Geckle
-
Patent number: 5533971Abstract: An electrotransport delivery device utilizing reservoir buffering at a select pH ranges in order to reduce skin irritation and skin resistance is provided. Cathodic reservoirs are buffered to a pH of less than about 4, preferably to a pH in the range of about 2 to 4, while anodic reservoirs are buffered to a pH above about 4, preferably to a pH in the range of about 4 to 10. Another electrotransport delivery device utilizes a potassium sensor to monitor potassium efflux from the skin. Potassium efflux above a certain predetermined level has been found to be a precursor to skin irritation/erythema. Operation of the device is modified (eg, terminated) when the predetermined potassium efflux level is sensed.Type: GrantFiled: September 3, 1993Date of Patent: July 9, 1996Assignee: Alza CorporationInventor: Joseph B. Phipps
-
Patent number: 5533957Abstract: A catheter for retroperfusion of myocardium has an infusion tip, such that when retroperfusing myocardium, the tip extends within the coronary sinus to a depth in a range of about 2 to 4 inches (5 to 10 cm) from the coronary sinus ostium. The catheter also comprises a tube defining at least three channels. The channels include an infusion channel, which has a first infusion end coupled to an infusion port located in the infusion tip and a second infusion end coupled to an outlet orifice of a pump; a withdrawal channel, which has a first withdrawal end coupled to a withdrawal port located in the superior vena cava and a second withdrawal end coupled to an inlet orifice of the pump; and a pressure monitoring channel for monitoring pressure at pressure port at the infusion tip having a first end coupled to the pressure port and a second monitoring end coupled to a pressure sensor.Type: GrantFiled: May 18, 1995Date of Patent: July 9, 1996Assignee: Trustees of Boston UniversityInventor: Gabriel S. Aldea
-
Patent number: 5533979Abstract: A thin blade shaped tool for the one-handed removal of a needle from an end of a syringe. The tool has an aperture in the center thereof for slideably mounting the tool on an end portion of the syringe, adjacent the needle, and sides extending outwardly from the syringe for a one-handed removal of said needle with a pair of fingers of a hand which holds the syringe. The sides have spaced apart ends and concave center portions for resting the syringe on a patient or IV line during an alignment of the needle with an injection site.Type: GrantFiled: March 1, 1994Date of Patent: July 9, 1996Inventors: Hossein Nabai, Homayoon Rahbari
-
Patent number: 5533970Abstract: A retractable needle syringe includes a barrel having an inside surface defining a chamber, an open proximal end and a distal end. An elongate plunger is slidably positioned in fluid-tight engagement with the inside surface of the barrel. The plunger includes a distal end, a proximal end and a radially directed projection on its distal end. A movable carrier is positioned in fluid-tight engagement with the inside surface of the barrel. The carrier includes an outside surface, a distal end, a proximal end, and a passageway therethrough in fluid communication with the chamber. The proximal end of the carrier includes an open-ended groove which is sized and shaped to receive the plunger projection. The groove includes an axial portion and a circumferential portion. The plunger is movable axially so that the plunger projection can enter and exit the axial portion of the groove.Type: GrantFiled: September 28, 1994Date of Patent: July 9, 1996Assignee: Becton, Dickinson and CompanyInventors: Howard S. Berger, Robert B. Odell, Sandor Gyure
-
Patent number: 5533976Abstract: A reusable cartridge assembly for a phaco machine includes a first plate with a plurality of flow channels therein and a sealing gasket with a sheet for sealing against the first plate to prevent fluid from leaving the flow channels. In addition, a tube is provided, fixed to the sealing gasket and protruding therefrom, for enabling engagement between the tube and a pump head for circulation of fluid through flow channels. A second plate is provided for applying a sealing pressure between the sheet and the first plate. In addition, the sealing gasket may include a sensing element for determining pressure within the flow channels.Type: GrantFiled: July 15, 1994Date of Patent: July 9, 1996Assignee: Allergan, Inc.Inventors: Edward R. Zaleski, Mark S. Cole
-
Patent number: 5531682Abstract: An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof.Type: GrantFiled: January 13, 1995Date of Patent: July 2, 1996Assignee: Abbott LaboratoriesInventors: Terrence B. Mazer, Joseph E. Walton, Ronita K. Geckle, Carl J. Piontek, Susan B. Duel, Andre Daab-Krzykowski, Robert L. Joseph, William G. Pierson, Thomas D. Loughrin, Thomas W. Osip
-
Patent number: 5531715Abstract: This invention is in the general field of surgical instruments. It relates specifically to catheters which may be used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vaso-occlusive agents to a target site within a human or animal body which is accessible by a system of natural passageways within that body. The catheters are coated in such a way that they are exceptionally slippery and the coating is very durable. The invention also relates to methods of coating the catheters and to methods of applying lubricious coatings.Type: GrantFiled: May 12, 1993Date of Patent: July 2, 1996Assignee: Target Therapeutics, Inc.Inventors: Erik T. Engelson, Robert Hergenrother, Joseph Eder
-
Patent number: 5531716Abstract: The present invention provides medical devices comprised of ionically crosslinked polymer, especially, stents, catheter or cannula components, plugs, and constrictors. The medical devices of the present invention are prepared by treatment of ionically crosslinkable polymer compositions with crosslinking ion compositions to provide ionically crosslinked materials.An important aspect of the present invention is that these medical devices can be disintegrated in-vivo at a desired time through the exposure of the medical device to a chemical trigger which generally is described as an agent that acts to displace the crosslinking ion in the ionically crosslinked material through binding or simple replacement with a non-crosslinking ion.Type: GrantFiled: September 29, 1993Date of Patent: July 2, 1996Assignee: Hercules IncorporatedInventors: Gary A. Luzio, Samuel A. Thompson
-
Patent number: 5531702Abstract: A patient controlled self injection aid is provided to enable a user with one hand to draw medication from a reservoir into a syringe, self inject, and properly dispose of the needle and syringe.Type: GrantFiled: May 4, 1995Date of Patent: July 2, 1996Assignee: Massillon Community HospitalInventors: Denise J. Baker, Glenn D. Blankenhorn, III, Lonnie R. Freeman, Heather B. Hann, Judy A. Hesse, Judy M. Kaforey, Darlene K. Piero