Patents Examined by Raymond
  • Hydrogenation process for the formation of 4A,5-dihydro HMG-CoA reductase inhibitors
    Patent number: 4876364
    Abstract: A novel hydrogenation process, employing an iridium or rhodium catalyst, in an alcoholic solvent mixture, for the reduction of the 4a,5 double bond in the polyhydronaphthyl ring of des-(.alpha.-methylbutyryl)-8-hydroxy-lovastatin or analogs thereof, is disclosed.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: October 24, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ann D. Schuda, Thomas R. Verhoeven, Ichiro Shinkai