Patents Examined by Raymond V. Rush
  • Coumarin derivatives
    Patent number: 3966755
    Abstract: The present invention relates to new coumarine derivatives in which coumarine residues substituted in 7-position or 5,6-benzo-coumarine residues are further substituted in 3-position by optionally further substituted 2-phenyl-triazol-4-yl 2- or 1-phenyl-pyrazol-4-yl.The new compounds are useful optical brighteners for organic materials.
    Type: Grant
    Filed: June 18, 1973
    Date of Patent: June 29, 1976
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans Schlapfer
  • Fluoro-substituted dibenso[b,f] thiepins
    Patent number: 3966737
    Abstract: Compounds of the formulas ##SPC1##Wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as hereinafter set forth,Are described. The compounds of formulas I and Ia are prepared inter alia by the reaction of the corresponding dibenzo[b,f] thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.
    Type: Grant
    Filed: May 17, 1974
    Date of Patent: June 29, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • 1,4-Dithino[2,3-c]pyrrole compositions
    Patent number: 3966931
    Abstract: New compounds of the formula: ##SPC1##Wherein A is a phenyl, pyridyl, pyridazinyl, 2-, 3- or 4-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, alkyl, alkoxy cyano and nitro, R is alkyl, alkenyl or hydroxyalkyl, and n is zero or 1, possess pharmacological properties and are, in particular, active as tranquilizers, anti-convulsant agents, decontracturants and agents to produce hypnosis.
    Type: Grant
    Filed: June 24, 1975
    Date of Patent: June 29, 1976
    Assignee: Rhone-Poulenc S.A.
    Inventors: Claude Jeanmart, Andre Leger, Mayer Naoum Messer
  • Pyrimidin(4)-yl-(thiono)-(thiol)-phosphoric-(phosphonic)-acid esters
    Patent number: 3966730
    Abstract: Pyrimidin(4)-yl-(thiono)-phosphoric-(phosphonic) acid esters and ester amides of the formula ##SPC1##In whichR.sup.1 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl or aralkyl,R.sup.2 is hydrogen, alkyl, alkoxy, alkylmercapto, alkylcarbonyl, alkoxycarbonyl, halogen, nitrile or thiocyanato,R.sup.3 is hydrogen, alkyl, aryl or alkoxycarbonylalkyl, orR.sup.2 is R.sup.3 conjointly form an alkylene bridge which forms a 5-membered to 7-membered ring with the adjoining carbon atoms,R.sup.4 is alkyl or alkoxyalkyl,R.sup.5 is alkyl, alkoxy, alkylmercapto, alkylamino, or aryl, andX is oxygen or sulfur,Which possess insecticidal, acaricidal and nematocidal properties.
    Type: Grant
    Filed: August 22, 1974
    Date of Patent: June 29, 1976
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Hofer, Fritz Maurer, Hans-Jochem Riebel, Lother Rohe, Wolfgang Behrenz, Ingeborg Hammann, Wilhelm Stendel, Bernhard Homeyer
  • N-3,5-dichlorophenyloxazalidines
    Patent number: 3966750
    Abstract: N-(3,5-dichlorophenyl)-5-H or lower alkyl-5-lower alkenyloxazolidine-2,4-diones or N-(3,5-dichlorophenyl)-5-methyleneoxazolidine-2,4-dione and fungicidal uses thereof.
    Type: Grant
    Filed: May 28, 1974
    Date of Patent: June 29, 1976
    Assignee: BASF Aktiengesellschaft
    Inventors: Dietrich Mangold, Bernd Zeeh, Ernst-Heinrich Pommer
  • Oxazolidines of 4-oxo-tricyclo[5.1.0.sup.2.5 ]octan-8-endo-carboxaldehyde, neopentyl glycol acetal
    Patent number: 3966751
    Abstract: Oxazolidines having the formula ##SPC1##Wherein .about. indicates endo or exo attachment, but differing in their stereoisomeric configuration, prepared by reaction of the isomers of an oxo compound of the formula ##SPC2##Wherein .about. is as defined above, with d- or l-ephedrine; useful for separating optically active isomers of the oxo compound.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: June 29, 1976
    Assignee: The Upjohn Company
    Inventor: Robert C. Kelly
  • Thiazolidinylidene isoindoline pigments
    Patent number: 3966753
    Abstract: This invention relates to novel compounds of the isoindoline series. More particularly, the present invention relates to certain novel 1-imino-3-(2-oxo-4-thioxo-5-thiazolidinylidene)isoindolines, 1-imino-3-(2,4-dithioxo-5-thiazolidinylidene)isoindolines, water-insoluble pigments prepared therefrom, and to methods for their preparation.
    Type: Grant
    Filed: August 9, 1974
    Date of Patent: June 29, 1976
    Assignee: Sterling Drug Inc.
    Inventors: Nathan N. Crounse, Nicholas A. Ambrosiano
  • Production of high molecular weight .alpha.,.beta.-unsaturated aldehydes
    Patent number: 3965193
    Abstract: A process for the production of high molecular weight .alpha., .beta.-unsaturated aldehydes by alkylation of the .gamma.-carbon atom of a lower molecular weight .alpha., .beta.-unsaturated aldehyde with a substituted allyl alcohol which has a chain branching in the 3-position carbon atom or a phenyl radical in the 3-position or of a corresponding allyl alcohol carboxylic ester at elevated temperature in the liquid phase.The products are valuable intermediates for the production of natural substances and odorants.
    Type: Grant
    Filed: November 1, 1972
    Date of Patent: June 22, 1976
    Assignee: Badische Anilin- & Soda-Fabrik Aktiengesellschaft
    Inventors: Norbert Goetz, Roman Fischer
  • Process for the manufacture of 2-aryl-v-triazole
    Patent number: 3965094
    Abstract: 2-Aryl-v-triazoles are obtained by reacting .alpha.-oximinoaryl-hydrazones of the formula ##EQU1## IN WHICH Ar represents an aromatic-carbocyclic or aromatic-heterocyclic radical, R.sub.1 denotes alkyl, aryl or nitro, R.sub.2 denotes hydrogen, alkyl or aryl and n denotes the numbers 1 or 2 with at least 2 equivalents of an isocyanate or carbamic acid halide or with at least 1 equivalent of a pyrocarbonic acid ester.
    Type: Grant
    Filed: March 2, 1973
    Date of Patent: June 22, 1976
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Claussen, Heinrich Gold, Josef Schroeder
  • Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins
    Patent number: 3963709
    Abstract: 7-Cyanomethylmercaptoacetamidocephalosporins, 7-cyanomethylsulfinylacetamidocephalosporins, and 7-cyanomethylsulfonylacetamidocephalosporins, which have antibacterial activity, are disclosed.
    Type: Grant
    Filed: February 11, 1975
    Date of Patent: June 15, 1976
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Tetracyclic imidazo [2,1-b] quinazolinone derivatives
    Patent number: 3963720
    Abstract: Disclosed are compounds which are tetracyclic derivatives of imidazo[2,1-b]quinazolinones, e.g., 6-(p-fluorobenzyl)-1,2,3,4,4a,12a-hexahydrobenzimidazo[2,1-b]quinazolin-11 (6H)-one. The compounds are also useful as bronchodilator agents, and certain compounds are also useful as tranquillizers and sedative/hypnotic agents. The compounds may be prepared by reacting an isatoic anhydride with a 2-organomercapto-hexahydrobenzimidazole or hexahydrocyclopentimidazole such as 3a,4,5,6,7,7a-hexahydro-2-mercaptomethyl-3H-benzimidazole.
    Type: Grant
    Filed: June 21, 1974
    Date of Patent: June 15, 1976
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Process for the preparation of aldehydes
    Patent number: 3963784
    Abstract: Aldehydes are prepared by metalating an aliphatic carboxylic acid with lithium diisopropylamide in a mixed solvent system of tetrahydrofuran-hexane-hexamethylphosphoramide to form a dianion of the acid, reacting the dianion in the mixed solvent system with ethyl formate and decarboxylating the resulting alpha-aldehyde acid salt.
    Type: Grant
    Filed: December 19, 1973
    Date of Patent: June 15, 1976
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Philip E. Pfeffer, Leonard S. Silbert
  • Substituted pyrazines
    Patent number: 3963715
    Abstract: Tetracyanopyrazine reacts with aromatic amines to give products of the formula ##SPC1##WhereinR.sup.1 and R.sup.2, alike or different, are alkyl of 1-12 carbon atoms, cycloalkyl of 3-7 carbon atoms, phenyl, p-(lower alkyl)-phenyl, p-(lower alkoxy)phenyl, p-(lower alkylthio)phenyl, p-chlorophenyl, p-bromophenyl,Aralkyl, aroxyalkyl, aroyloxyalkyl, acyloxyalkyl and trifluoroacetoxyalkyl each of up to 15 carbon atoms, and wherein aryl is phenyl substituted with up to 2 lower alkyl groups, and with the proviso that the alkylene group of aroyloxyalkyl, acyloxyalkyl and trifluoroacetoxyalkyl is at least 2 carbon atoms in length;R.sup.3 is hydrogen, lower alkyl, alkoxy or alkylthio of 1-6 carbons.The cyano groups of the pyrazine ring can be converted to acid, ester or amide groups by conventional reactions.The compounds are useful as dyes and pigments.
    Type: Grant
    Filed: May 25, 1973
    Date of Patent: June 15, 1976
    Assignee: E. I. Du Pont de Nemours & Company
    Inventors: Donald R. Baer, Allan Cairncross, Michael Smith
  • Cyclopentano (h) or (f) 1,2,3,4-tetrahydroisoquinolines
    Patent number: 3963723
    Abstract: Provided are novel cyclopentano-1,2,3,4-tetrahydroisoquinolines of the formula ##SPC1##Wherein R and R.sub.1 are the same or different lower alkyl groups, R.sub.2 is hydrogen or a lower alkyl group, m is an integer from 1 to 2, n is an integer from 1 to 2 and m + n equals 3, and acid addition salts thereof, processes for making the compounds and pharmaceutical compositions containing one or more of the compounds useful as hypotensive agents. Also provided are intermediates of the formula ##SPC2##Wherein R and R.sub.1 are the same or different lower alkyl groups and R.sub.3 is hydrogen, CHO--, ##EQU1## wherein R.sub.2 is hydrogen or a lower alkyl group.
    Type: Grant
    Filed: March 28, 1974
    Date of Patent: June 15, 1976
    Assignee: Marion Laboratories, Inc.
    Inventors: Ian William Mathison, William Ebenezer Solomons, Raymond Henry Jones
  • Tricyclic furo-quinazolinones
    Patent number: 3963717
    Abstract: Anti-inflammatories and analgesics of the formula ##SPC1##WhereinX y is --OCH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 O--,R is lower alkyl, allyl or cycloalkylalkyl andR' is phenyl or phenyl monosubstituted by halo, alkyl, alkoxy or trifluoromethyl,Are prepared by oxidation of the corresponding dihydro intermediates.
    Type: Grant
    Filed: March 10, 1975
    Date of Patent: June 15, 1976
    Assignee: Sandoz, Inc.
    Inventors: George A. Cooke, William J. Houlihan
  • Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins
    Patent number: 3963711
    Abstract: 7-Cyanomethylmercaptoacetamidocephalosporins, 7-cyanomethylsulfinylacetamidocephalosporins, and 7-cyanomethylsulfonylacetamidocephalosporins, which have antibacterial activity, are disclosed.
    Type: Grant
    Filed: February 11, 1975
    Date of Patent: June 15, 1976
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Tetrahydropyrimidines
    Patent number: 3963718
    Abstract: Compounds of the class of imidazo[1,2-a]-imidazoles, imidazo[1,2-a]pyrimidines and pyrimido-[1,2-a]pyrimidines useful as central nervous system (CNS) antidepressants; and certain novel precursors therefor.
    Type: Grant
    Filed: April 16, 1975
    Date of Patent: June 15, 1976
    Assignee: Janssen Pharmaceutica
    Inventors: Josephus Ludovicus Hubertus Van Gelder, Alfons Herman Margaretha Raeymaekers, Leopold Frans Cornell Roevens, Willy Joannes Van Laerhoven
  • 2-(Piperazinoethyl)-6,7-dihydroindol)[1,7-an] [1]benzazepine
    Patent number: 3963721
    Abstract: Novel 2-(aminoalky)-6,7-dihydroindolo[1,7-ab] 1,7-ab][1]benzazepines and acid-addition salts thereof having antibacterial activity, and intermediate and process for the preparation thereof are disclosed.
    Type: Grant
    Filed: June 19, 1975
    Date of Patent: June 15, 1976
    Assignee: Sterling Drug Inc.
    Inventor: Ernest John Alexander
  • Bis-oxadiazolyl phenyl aromatic diester compounds and their use as ultraviolet stabilizers in organic compositions
    Patent number: 3963738
    Abstract: The invention relates to bis-oxadiazolyl phenyl aromatic diesters compounds which have been found to be extremely effective ultraviolet stabilizers. The invention also relates to ultraviolet degradable organic compositions containing an amount of a bis-heterocyclic benzoate composition to prevent such degradation. These stabilizers are effective in the presence of other additives commonly employed in polymeric compositions including, for example, pigments, colorants, fillers, reinforcing agents and the like. These ultraviolet stabilizers may also be incorporated into the organic compositions such as polymers by adding to the polymer melt or dissolved in the polymer dope, coated on the exterior of the shaped or molded article, film or extruded fiber.
    Type: Grant
    Filed: July 1, 1974
    Date of Patent: June 15, 1976
    Assignee: Eastman Kodak Company
    Inventors: Gether Irick, Jr., Charles A. Kelly
  • 4,5 Dihalopyrrol 2-yl di and tri halomethyl ketones
    Patent number: 3963746
    Abstract: 4,5-Dihalopyrrol-2-yl di- and trihalomethyl ketones, prepared by reaction of pyrrole with a di- or trihaloacetyl halide or with a di- or trihaloacetic anhydride and halogenation of the resulting pyrrol-2-yl di- or trihalomethyl ketone, useful as antibacterial, herbicidal and insecticidal agents.
    Type: Grant
    Filed: April 28, 1975
    Date of Patent: June 15, 1976
    Assignee: Sterling Drug Inc.
    Inventor: Denis M. Bailey