Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.
The compounds of formulae I, II, III and IV have the structure:
wherein:
X, X4, X5, X7, X9;
R1, R2, R3, R4; and
Y, Z and n are as described in the specification.
Type:
Grant
Filed:
February 4, 2002
Date of Patent:
June 3, 2003
Assignee:
Adolor Corporation
Inventors:
Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang