Patents Examined by Rebecca Anderson
  • Patent number: 9902739
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: February 27, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Brian Rich, Nikolai Sepetov, Robert Greenhouse, Artem Plekhov, Wen Yang, Zhiwei Tong
  • Patent number: 9862678
    Abstract: This disclosure relates to a novel class of compounds having the structure of formula I as defined herein and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. This disclosure also comprises methods of treating a subject by administering a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof to the subject. These compounds are useful for the conditions disclosed herein. This disclosure further comprises methods for making the compounds of formula I and corresponding intermediates.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: January 9, 2018
    Assignees: VIB VZW, Universiteit Gent, Universiteit Antwerpen
    Inventors: Peter Vandenabeele, Tom Vanden Berghe, Koen Augustyns, Jurgen Joossens, Pieter Van Der Veken, Sam Hofmans
  • Patent number: 9862710
    Abstract: The present invention relates to novel oxazolidinone compounds of general formula (I) having antibiotic activity also against multiresistant bacterial strains.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 9, 2018
    Assignees: ISTITUTO EURO MEDITERRANEO DI SCIENZA E TECNOLOGIA, UNIVERSITA' DEGLI STUDI DI MILANO—BICOCCA
    Inventors: Rosario Musumeci, Clementina Elvezia Anna Cocuzza, Cosimo Gianluca Fortuna, Andrea Pace, Antonio Palumbo Piccionello
  • Patent number: 9856276
    Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: January 2, 2018
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Atsushi Endo, Charles E. Chase, Francis G. Fang
  • Patent number: 9845319
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R5, A1, A2, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: December 19, 2017
    Assignee: Janssen Pharmaceutiuca NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Virginia Tanis, Maud Urbanski, Aihua Wang, David Kummer, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann, Anne M. Fourie, Xiaohua Xue
  • Patent number: 9840472
    Abstract: The invention relates to the compounds of formula I, formula II, formula III and formula IV or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III or formula IV and methods for the treatment of mucositis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of mucositis and oral mucosal inflammatory or oral infectious diseases.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: December 12, 2017
    Assignee: CELLIX BIO PRIVATE LIMITED
    Inventor: Mahesh Kandula
  • Patent number: 9834560
    Abstract: The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 5, 2017
    Assignee: Respivert Ltd.
    Inventors: John King-Underwood, Kazuhiro Ito, Peter John Murray, George Hardy, Frederick Arthur Brookfield, Christopher John Brown
  • Patent number: 9828349
    Abstract: Compounds of the formula where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 28, 2017
    Assignees: EXONHIT THERAPEUTICS SA, ALLERGAN, INC.
    Inventors: Bertrand Leblond, Eric Beusoleil, Thierry Taverne, John E. Donello
  • Patent number: 9822095
    Abstract: A tetrazolinone compound represented by formula (1): wherein R1 and R2 each independently represents a hydrogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, etc.; R3 represents a hydrogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, etc.; R4 represents a halogen atom, a C1-C4 alkyl group optionally having one or more halogen atoms, etc.; h represents any one of integers of 0 to 4; X represents a nitrogen atom or CR5; and R5 represents a hydrogen atom, a halogen atom, etc.; has excellent control activity against pests.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: November 21, 2017
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Koichiro Dota
  • Patent number: 9814725
    Abstract: This invention generally relates to substituted imidazopyridine compounds, particularly substituted 4-(imidazo[1,2-a]pyridin-2-yl)benzamide compounds and salts thereof. This invention also relates to pharmaceutical compositions and kits comprising such a compound, uses of such a compound (including, for example, treatment methods and medicament preparations), processesor making such a compound, and intermediates used in such processes.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: November 14, 2017
    Assignee: NEOMED INSTITUTE
    Inventors: Christophe Buon, Louis-David Cantin, Yun-Jin Hu, Xuehong Luo, Miroslaw Jerzy Tomaszewski
  • Patent number: 9808458
    Abstract: The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula I: Q-Y—R1—R2??(I), wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula I in combination with any one or more compounds represented by formulas II, V, and VI. Use of the pharmaceutical compositions for treating or preventing malaria or for inhibiting a plasmodial surface anion channel in animals including humans are also provided. Also provided by the invention are clag3 amino acid sequences and related nucleic acids, vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: November 7, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventor: Sanjay A. Desai
  • Patent number: 9809533
    Abstract: The purification method of an aldehyde compound of the present invention includes a step of neutralizing a reaction solution containing an aldehyde compound by adding water and a base compound to the reaction solution, and a step of distilling the neutralized reaction solution, in which the reaction solution is obtained by reacting a compound represented by the following Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, the phosphorus compound is represented by Formula (R1O)3P, and the base compound is at least one kind selected from among carbonate and hydrogen carbonate of metals of group I on the periodic table and carbonate and hydrogen carbonate of metals of group II on the periodic table.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: November 7, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Naoyuki Kakinuma, Masayuki Furuya, Michiharu Sakata, Koichi Tokunaga, Shigetoshi Kuma
  • Patent number: 9802896
    Abstract: The present, invention relates to a process for large scale production of N-[4-(1-Cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride of formula (I).
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: October 31, 2017
    Assignee: Suven Life Sciences Limited
    Inventors: Ramakrishna Nirogi, Anil Karbhari Shinde, Ramasastri Kambhampati, Venkateswarlu Jasti
  • Patent number: 9796672
    Abstract: Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: October 24, 2017
    Assignee: COGNITION THERAPEUTICS, INC.
    Inventors: Gilbert Rishton, Susan M. Catalano, Gary C. Look
  • Patent number: 9796689
    Abstract: By either forming a triaryl acid halide or a triaryl mixed anhydride and subsequently treating with aqueous sodium azide, triaryl acyl azides are prepared in high yield using inexpensive reagents in a process in which by-products are easily removed from the triaryl acyl azide.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: October 24, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Peter Borromeo, Carl DeAmicis
  • Patent number: 9790497
    Abstract: Using a morpholino nucleotide wherein 5?-hydroxy group or a hydroxy group present on the substituent of the 5?-hydroxy group is protected by a protecting group having an alkyl group having not less than 10 and not more than 300 carbon atoms and/or an alkenyl group having not less than 10 and not more than 300 carbon atoms as a starting material, a method capable of efficiently producing the morpholino oligonucleotide in a high yield by a liquid phase synthesis can be provided.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: October 17, 2017
    Assignee: AJINOMOTO CO., INC.
    Inventors: Takayoshi Torii, Daisuke Takahashi, Satoshi Katayama
  • Patent number: 9790230
    Abstract: The present invention relates to compounds of formula of formula I wherein X, L and R1 are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula I.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: October 17, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Giuseppe Cecere, Guido Galley, Yimin Hu, Roger Norcross, Philippe Pflieger, Hong Shen
  • Patent number: 9788547
    Abstract: A pest control agent comprising an aromatic compound represented by formula (1) wherein R1 represents a halogen atom, etc.; R3 represents a hydrogen atom, etc.; R7 represents a C1-C3 alkyl group optionally having one or more halogen atoms, etc.; Z2 represents a halogen atom, etc.; Z3 represents a C1-C3 alkyl group optionally having one or more halogen atoms, etc.; and Q represents the following group Q1, Q2, or Q3 has excellent control activity.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: October 17, 2017
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yuki Akioka, Takayuki Shioda, Sadayuki Arimori
  • Patent number: 9783506
    Abstract: The present invention provides a process for the large scale production of 1H-[1,2,3]triazole of formula (I) and its intermediate 1-benzyl-1H-[1,2,3]triazole of formula (II) by using benzyl azide and vinyl acetate as starting materials. This process is economical, environment friendly and safer by avoiding use of special equipment.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: October 10, 2017
    Assignee: SUVEN LIFE SCIENCES LIMITED
    Inventors: Veera Reddy Arava, Sashibhushan Malreddy, Chalapathi Lagupudi, Venkateswarlu Jasti
  • Patent number: 9783538
    Abstract: The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: October 10, 2017
    Assignee: ASTEX THERAPEUTICS LIMITED
    Inventors: Gianni Chessari, Christopher Norbert Johnson, Steven Howard, James Edward Harvey Day, Ildiko Maria Buck, Charlotte Mary Griffiths-Jones, Gordon Saxty, Emiliano Tamanini, Nicola Elisabeth Wilsher