Patents Examined by Rebecca Cook
  • Composition for treatment of external secretion disorders except hypol acrimation
    Patent number: 6339088
    Abstract: A composition for treatment of external secretion disorders except hypolacrimation which comprises, as an active ingredient, an aldose reductase inhibitor. The composition is effective in at least one of diseases selected from hyposalivation and dry mouth syndrome.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: January 15, 2002
    Assignee: R-Tech Ueno. Ltd.
    Inventors: Ryuji Ueno, Ichie Kato
  • Pyrimidine derivatives
    Patent number: 6337334
    Abstract: The present invention is directed to a pyrimidine derivative of the following formula (1) or a salt of the derivative: [wherein R1 represents a lower alkyl group; each of R2 and R3 represents H, alkyl, or alkoxy; each of R4 and R5 represents H or alkyl; R6 represents alkyl, —OR7, or —NR8R9; and n is a number between 0 and 3 inclusive (wherein each of R7, R8, and R9 represents H, alkyl, aryl, aralkyl, amino, a heterocyclic ring, etc.)], as well as to a medicine containing the derivative or salt as the active ingredient. The present compounds exhibit strong binding inhibitory activity against endothelin having potent vasoconstrictive effect and cell proliferation effect. Therefore, the compounds are effective as remedies for various diseases including circulatory diseases.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: January 8, 2002
    Assignee: Kowa Co., Ltd.
    Inventors: Mitsuteru Hirata, Takeo Deushi, Yoshio Takahashi, Masahiro Tamura, Takeshi Ohshima, Toshiaki Oda, Hiroyuki Sonoki, Masami Shiratsuchi
  • Hydroxylansoprazole compositions and methods
    Patent number: 6335351
    Abstract: Methods and compositions are disclosed utilizing hydroxylansoprazole for the treatment of ulcers in humans. Hydroxylansoprazole exhibits a lessened liability toward drug-drug interactions than lansoprazole and a more predictable dosing regimen than lansoprazole. Hydroxylansoprazole is also usefull for the treatment of gastroesophageal reflux and other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: January 1, 2002
    Assignee: Sepracor Inc.
    Inventor: William E. Yelle
  • Pharmaceutical composition for the treatment of diabetes
    Patent number: 6329403
    Abstract: A pharmaceutical composition which comprises an insulin sensitizer in combination with an anorectic, which is useful as an agent for preventing or treating diabetes.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: December 11, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroyuki Odaka, Masahiro Yamane
  • Tetrazole-containing rapamycin analogs with shortened half-lives
    Patent number: 6329386
    Abstract: A compound having the formula or a pharmaceutically acceptable salt or prodrug thereof, is an immunomodulatory agent and is useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosois, post-transplant tissue rejection, and immune and autoimmune disease in a mammal.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: December 11, 2001
    Assignee: Abbott Laboratories
    Inventor: Karl W. Mollison
  • Treatment of hyperproliferative skin disorders with C18 to C20 aliphatic alcohols
    Patent number: 6313179
    Abstract: A method is disclosed for treating a benign or malignant hyperproliferative skin lesion, comprising topically administering a C18 to C20 aliphatic alcohol to the skin lesion in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: November 6, 2001
    Assignee: Avanir Pharmaceuticals
    Inventors: Laura E. Pope, Mohammed H. Khalil, John F. Marcelletti, Lee R. Katz, David H. Katz
  • Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors
    Patent number: 6303619
    Abstract: The invention concerns the use of a xanthine or a xanthine derivative having a meta-substituted acidic aryl at the 8-position to specifically modulate the physiologic role of adenosine activation of its various receptors.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: October 16, 2001
    Assignees: University of Virginia, University of Virginia Patent Foundation
    Inventor: Joel M. Linden
  • 4-aminoquinazoline derivative cGMP-PDE inhibitors for the treatment of erectile dysfunction
    Patent number: 6300335
    Abstract: 4-aminoquinazoline derivatives which are selective inhibitors of cGMP PDE are useful in the treatment of erectile dysfunction (impotence) in male animals, including man.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: October 9, 2001
    Assignee: Pfizer Inc.
    Inventors: Simon Fraser Campbell, Alexander Roderick Mackenzie, Anthony Wood
  • Method of preventing the effects of altered &Dgr;-5 pathway steroidogenesis in adrenergically blockaded conditions
    Patent number: 6297288
    Abstract: The production of sex steroids by the &Dgr;-5 steroidogenic pathway has been found to be under control of the adrenergic nervous system, and sex steroids produced by this pathway are diminished in individuals with adrenergically-blockaded conditions. This invention relates to diminishing the consequences of suppressed &Dgr;-5 pathway steroidogenesis in individuals with adrenergically blockaded conditions by the administration of compositions which raise the serum levels of sex steroids.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: October 2, 2001
    Inventor: Robert E. Weinstein
  • Treatment of schizophrenia and psychosis
    Patent number: 6297262
    Abstract: The compound 5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine has shown effects on models of psychosis, schizophrenia and schizophreniform diseases and is useful for the manufacture of a pharmaceutical preparation for the treatment of such diseases.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: October 2, 2001
    Assignee: H. Lundbeck A/S
    Inventors: Frank Sams-Dodd, Jorn Arnt
  • Methods of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 6294565
    Abstract: The present invention provides methods for treating Crytococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: September 25, 2001
    Assignees: University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Treatment of spinal cord injuries
    Patent number: 6291493
    Abstract: The present invention relates to a new medical use of 5-(2-chloroethyl)-4-methylthiazole and the pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions containing it. In particular, the present invention relates to the use of clomethiazole for the prevention and/or treatment of spinal cord injury.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: September 18, 2001
    Assignee: AstraZeneca AB
    Inventors: Mohammad Farooque, David Jackson, Yngve Olsson
  • Use of pyrethroid compounds to promote hair growth
    Patent number: 6288112
    Abstract: A method of promoting hair growth which includes administering to a subject an effective amount of a pyrethroid. A composition having a pyrethroid and a pharmaceutically acceptable carrier for promoting hair growth is also described.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: September 11, 2001
    Assignee: The General Hospital Corporation
    Inventors: Toshihiko Seki, Seishiro Fujii, Gianpaolo Dotto
  • Composition for treating asthma
    Patent number: 6281248
    Abstract: A method of treating asthma that includes the step of controlling the asthma by ingesting a composition which includes a selective serotonin reuptake inhibitor that is sertraline hydrochloride. Chronic administration of the sertraline thereof downregulates brain norepinephrine receptors. The increased output of the brain norepinephrine receptors increases the dilation of the bronchi. Sertraline has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors. Antagonism of such receptors has been hypothesized to be associated with various adverse anticholinergic, sedative, and cardiovascular effects.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: August 28, 2001
    Inventor: Magda Abdel Fattah Ahmed
  • Chemical compounds
    Patent number: 6277880
    Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: August 21, 2001
    Assignees: Zeneca Limited, Cancer Research Campaign Technology Limited
    Inventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
  • Use of R- +)-&agr;-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders
    Patent number: 6277864
    Abstract: A method of treating a patient for a Sleep Disorder comprising administering an effective amount of R-(+)-&agr;-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol or a pharmaceutically acceptable salt thereof to a patient in need of such treatment.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: August 21, 2001
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Cesare Mondadori, Stephen M. Sorensen, Janice M. Hitchcock
  • Preparation for the treatment of metabolic syndrome containing human growth hormone in combination with a cortisol synthesis inhibitor
    Patent number: 6274582
    Abstract: Human growth hormone is used in combination with a cortisol synthesis inhibitor, in particular ketoconazole, for prevention or treatment of conditions related to Metabolis Syndrome (Neuroendocrine Syndrome). Administration can be supplemented by a sex hormone selected from testosterone and natural or synthetic estrogen. Also disclosed are corresponding pharmaceutical compositions.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: August 14, 2001
    Assignee: Cortendo AB
    Inventor: Per Mårin
  • Heterocyclic thioester and ketone hair growth compositions and uses
    Patent number: 6274602
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic thioesters and ketones.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: August 14, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Heterocyclic ester and amide hair growth compositions and uses
    Patent number: 6274617
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic esters or amides.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: August 14, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Prevention/retardation of hair growth
    Patent number: 6271260
    Abstract: A composition and method for retarding or preventing hair growth, wherein the composition includes a) citric acid, b) an electrolyte, and c) a cosmetically acceptable aqueous vehicle which includes a film forming agent.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: August 7, 2001
    Inventors: Laura Kahale, Malcolm Nearn