Patents Examined by Rebecca Coole
  • 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
    Patent number: 5286721
    Abstract: 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds of the formula: ##STR1## in which R.sup.1 is carboxy, COO.sup.-- or protected carboxy,R.sup.2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.8 is hydrogen or lower alkyl,Z is a group of the formula: ##STR2## wherein R.sup.3 is hydrogen; lower alkyl or lower alkenyl, each of which is optionally substituted by the group consisting of lower alkoxy, carbamoyl, hydroxy, halogen, mono(or di)(lower)alkylcarbamoyl, mono(or di)(lower)alkenylcarbamoyl, mono(or bis)[hydroxy(lower)alkyl]carbamoyl, optionally substituted cyclic-aminocarbonyl, acylamino, ureido, optionally substituted heterocyclic-carbonylamino, carbamoyloxy, mono(or di)(lower)alkylcarbamoyloxy, lower alkylthio, halo(lower)alkylthio, optionally substituted heterocyclicthio, optionally substituted heterocyclic group, optionally substituted aryl, and acyl;R.sup.9 is hydrogen or lower alkyl, andR.sup.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: February 15, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masayoshi Murata, Toshiyuki Chiba, Hideo Tsutsumi, Kohji Hattori, Satoru Kuroda, Hiroaki Ohtake, Fumiyuki Shirai
  • 2-phenyl-carbapenems
    Patent number: 5256777
    Abstract: Carbapenems of the formula ##STR1## are useful intermediates to antibacterial agents.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: October 26, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Frank DiNinno, Ravindra N. Guthikonda
  • Use of formoterol for treatment of tissue injury
    Patent number: 5135954
    Abstract: Formoterol, a known .beta.-adrenergic agonist, which, when administered intravascularly, has been found to profoundly reduce plasma extravasation resulting from tissue damage consequent to injury induced, for example, by surgery.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: August 4, 1992
    Assignee: The Regents of the University of California
    Inventor: Donald M. McDonald