Patents Examined by Rebecca Fritchman
-
Patent number: 7807472Abstract: Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.Type: GrantFiled: April 15, 2003Date of Patent: October 5, 2010Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Xia Xu, Regina G. Ziegler, David J. Waterhouse, Joseph E. Saavedra, Larry K. Keefer
-
Patent number: 7790467Abstract: An apparatus and method for quantifying ketone or alydehyde concentrations of gas. The invention includes passing a gas sample through a reactor and an optical cell and determining a concentration of a gaseous reaction product. Using the concentration of the gaseous reaction product and a predetermined reaction conversion efficiency, a ketone or aldehyde concentration is calculated. This invention can be used for diabetes screening, diabetes maintenance, identification and quantification of ketosis, explosives detection and formaldehyde detection.Type: GrantFiled: September 4, 2007Date of Patent: September 7, 2010Assignee: Southwest Sciences IncorporatedInventor: Steven Michael Massick
-
Patent number: 7759128Abstract: The histamine detection method of the invention includes: a reaction step of causing a sample solution possibly containing histamine to react with 2,3-naphathalene dicarboxylaldehyde at PH of less than 10; and a detection step of detecting histamine based on a color change in the reaction step. The arrangement of this histamine detection method ensures the good color development in a visible region and thus enables easy and quick detection of histamine.Type: GrantFiled: March 18, 2005Date of Patent: July 20, 2010Assignee: Nagoya Industrial Science Research InstituteInventor: Shigeyuki Oguri
-
Patent number: 7749769Abstract: The present invention relates to a new method for identifying polypeptides by deducing the amino acid sequence of the carboxy and amino termini by a mass spectrometer analysis. The method comprises the steps of dissociating highly charged peptide precursor ions (e.g., z>4) using electron transfer dissociation inducing anions followed by removal of those reagents and introduction of a second, proton transfer inducing anion type. The second PTR reaction duration is adjusted to convert the ETD products to primarily the +1 charge-state to reduce the highly charged c and z-type fragments, producing an m/z spectrum containing a series of c and z-type fragment ions that are easily interpreted to reveal the sequence of the amino and carboxy terminus, respectively.Type: GrantFiled: October 7, 2005Date of Patent: July 6, 2010Assignee: University of Virginia Patent FoundationInventors: Donald F Hunt, Joshua J. Coon, John Edward Philip Syka
-
Patent number: 7691641Abstract: The present invention relates to macromolecular polysaccharide-peptide conjugates which contain a peptide portion which C-terminally contains the amino acid sequence Ala-Gly-Arg, which is cleaved by thrombin.Type: GrantFiled: July 30, 2007Date of Patent: April 6, 2010Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Daniela Stoellner, Thilo Henckel
-
Patent number: 7687274Abstract: The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyze samples without pre-treatment or to analyze samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected.Type: GrantFiled: January 14, 2008Date of Patent: March 30, 2010Assignee: Aventis Pharma S.A.Inventors: Christian Viskov, Pierre Mourier
-
Patent number: 7641786Abstract: The invention relates to a method for analyzing a lubricating oil for low temperature properties. The method utilizes 2-dimensional gas chromatography (2D GC) to determine the amounts of paraffins and isoparaffins in the oil. In particular, the method analyzes for a particular isoparaffin fraction which is correlated to low temperature performance. The compositional information thus obtained is correlated with formulated oil Mini Rotary Viscometer (MRV) properties.Type: GrantFiled: November 14, 2005Date of Patent: January 5, 2010Assignee: ExxonMobil Research and Engineering CompanyInventors: Frank Cheng-Yu Wang, Lei Zhang
-
Patent number: 7642095Abstract: A process for producing lube basestocks involving solvent dewaxing a waxy feed to produce at least a partially dewaxed lube oil boiling range stream and then hydrodewaxing the partially dewaxed lube oil boiling range stream to produce a lube basestock.Type: GrantFiled: November 14, 2005Date of Patent: January 5, 2010Assignee: ExxonMobil Research and Engineering CompanyInventors: Frank Cheng-Yu Wang, Lei Zhang
-
Patent number: 7622305Abstract: Embodiments of techniques for determining the concentrations of one or more acid components of a multiple acid solution are presented herein.Type: GrantFiled: August 25, 2006Date of Patent: November 24, 2009Assignee: Intel CorporationInventors: Hok-Kin Choi, Vani Thirumala, Yongmei Wu
-
Patent number: 7582259Abstract: A blood analysis device for centrifugally separating plasma in a channel, wherein conveyance of blood, plasma and calibration liquid is effected within the device without using a pump or the like. The calibrator solution is reliably discharged from a sensor portion so as to make high precision analysis possible. A sensor section is provided in a plasma separating section and disposed on the side associated with a first centrifugal pressing direction as seen from a blood reservoir and a calibrator solution reservoir, while a calibrator solution waste reservoir is disposed in a second centrifugal pressing direction as seen from the plasma separating section (sensor section). The calibrator solution is conveyed to the sensor section by centrifugal operation in the first centrifugal direction. After sensor calibration, the calibrator solution can be reliably discharged from the sensor section by effecting centrifuging in the second centrifugal direction.Type: GrantFiled: February 18, 2004Date of Patent: September 1, 2009Assignee: Japan Science and Technology AgencyInventors: Hiroki Ogawa, Yasuhiro Horiike
-
Patent number: 7534618Abstract: Systems and methods for fractionating components of a sample are disclosed herein. A method of fractionating components of a sample includes establishing a solution density gradient in a capillary channel, applying the sample to the capillary channel, and centrifuging the sample in the capillary channel, thereby separating the components of the sample by density.Type: GrantFiled: July 27, 2007Date of Patent: May 19, 2009Assignee: Hewlett-Packard Development Company, L.P.Inventors: David A. Tyvoll, Kirk W. Norton
-
Patent number: 7531361Abstract: Provided are a coloration agent for carbonyl sulfide which contains a metal oxide, and at least one metal component selected from among a cerium component, a silver component, a copper component, a nickel component, and an iron component, the metal component being supported on the metal oxide, or which contains at least one metal oxide selected from among a cerium oxide, a silver oxide, a copper oxide, a nickel oxide, and an iron oxide; carbonyl sulfide detection means including the coloration agent for carbonyl sulfide; and a fuel cell system including the detection means. The coloration agent for carbonyl sulfide has the ability to develop a color in the presence of carbonyl sulfide even at ambient temperature, exhibits excellent performance in detecting carbonyl sulfide contained in a hydrocarbon fuel, and enables the service life of a desulfurizing agent to be determined through visual observation.Type: GrantFiled: August 5, 2005Date of Patent: May 12, 2009Assignee: Idemitsu Kosan Co., Ltd.Inventors: Kozo Takatsu, Gakuji Takegoshi
-
Patent number: 7521243Abstract: A sample acquiring device for volumetric enumeration of white blood cells in a blood sample that includes a measurement cavity for receiving a blood sample. The measurement cavity has a predetermined fixed thickness. The sample acquiring device also has a reagent, which is arranged in a dried form on a surface defining the measurement cavity. The reagent has a hemolysing agent for lysing red blood cells in the sample and a staining agent for selectively staining white blood cells in the sample. Also, a system with the sample acquiring device and a measurement apparatus. The measurement apparatus has a sample acquiring device holder, a light source, and an imaging system for acquiring a digital image of a magnification of the sample The measurement apparatus also has an image analyzer arranged to analyze the acquired digital image for determining the number of white blood cells in the blood sample.Type: GrantFiled: April 11, 2005Date of Patent: April 21, 2009Assignee: Hemocue ABInventors: Stellan Lindberg, Johnny Svensson
-
Patent number: 7507583Abstract: A method of analyzing relatively large soil samples for actinides by employing a separation process that includes cerium fluoride precipitation for removing the soil matrix and precipitates plutonium, americium, and curium with cerium and hydrofluoric acid followed by separating these actinides using chromatography cartridges.Type: GrantFiled: March 27, 2006Date of Patent: March 24, 2009Assignee: Savannah River Nuclear Solutions, LLCInventor: Sherrod L. Maxwell, III
-
Patent number: 7507374Abstract: In a lateral test flow immunoassay device, a saliva sample and a buffer solution are delivered into a mixing chamber to mix with a second reagent. The resulting test mixture is allowed to incubate for a pre-determined period of time and then selectively delivered to a test strip.Type: GrantFiled: October 19, 2005Date of Patent: March 24, 2009Assignee: American Bio Medica Corp.Inventors: Martin Gould, Robert Bernstine