Patents Examined by Rebecca L Martinez
  • Patent number: 10520515
    Abstract: Methods, devices, and reagents are described for performing assays for hemoglobin Ale, glycated albumin, and other glycated proteins. The methods involve a ratio determination between glycated protein and non-glycated protein. In some applications, the assay utilizes LOCI for signal generation. This invention is directed to assays and corresponding devices and reagents for detection of glycated protein, particularly including glycated hemoglobin. As is generally understood, such detection is useful in the management of blood glucose levels in diabetic patients and for monitoring the status of pre-diabetic individuals.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: December 31, 2019
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Victor Manneh, Sergei Svarovsky, Anthony Prestigiacomo
  • Patent number: 10520511
    Abstract: Improved capillary zone electrophoresis (CZE), affinity capillary electrophoresis (ACE), and partially filled-ACE (PF-ACE) systems and methods for the detection and quantification of specific molecular entities in a mixture thereof are provided. During manufacturing, heterodimeric bispecific antibodies are often produced along with homodimer species, which can confound quantification of the bispecific antibody. Disclosed are capillary electrophoretic systems and methods of detecting a specific homodimer in the mixture of bispecific heterodimer and homodimers. A ligand capable of binding one of the subunits of the bispecific antibody is contacted with the mixture to form a complex having a reduced electrophoretic mobility, thereby enabling detection of the unbound homodimer.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 31, 2019
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kathir Muthusamy, Jiann-Kae Luo
  • Patent number: 10520497
    Abstract: A housing case that includes an inspection strip, a first pot in which a first amplification liquid is sealed, and a second pot in which a second amplification liquid is sealed, includes a lower case, an upper case, and an intermediate member disposed therebetween, in which the upper case includes, on a part facing the first pot, a first protrusive deforming portion that deforms towards a side of the first pot when applied with pressing force from outside, whereby a tearing portion of the intermediate member tears a sheet member of the first pot, and includes, at a part facing the second pot, a second protrusive deforming portion that deforms towards a side of the second pot when applied with pressing force from outside, whereby a sheet member of the second pot is torn.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: December 31, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Atsuhiko Wada, Akira Wakabayashi, Keiji Shigesada
  • Patent number: 10513729
    Abstract: Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: December 24, 2019
    Assignee: STOKES BIO LIMITED
    Inventors: Mauro Aguanno, Brian T. Chawke, Kieran Curran, Tara Dalton, Mark Davies, Xiaona Hou, David Kinahan, Mark Korenke, David McGuire, Michael Sayers, Noel Sirr, Ryan J. Talbot, Brian Barrett, Damian Curtin, Damien King, Conor McCarthy
  • Patent number: 10509030
    Abstract: Disclosed herein are an artificial cell membrane including a supported lipid bilayer (SLB) including a substrate and mobility-decreased metal particles bonded onto the substrate; an analysis device or kit including the artificial cell membrane and examining the interactions between molecules, in which one molecule is bonded to the surface of a mobility-decreased metal particle bonded to the artificial cell membrane and the other molecule is bonded to the surface of a mobility-increased metal particle bonded to a lipid at a low valency; a method of examining the interactions between molecules using the analysis device; a kit for quantitative or qualitative analysis of a target material including the artificial cell membrane by plasmonic scattering measurements; and a multiple analysis kit capable of detecting a plurality of target materials using a plurality of metal particles having different plasmonic scattering wavelengths and/or having mobility on a supported lipid bilayer.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: December 17, 2019
    Assignees: Seoul National University R&DB Foundation, BioNano Health Guard Research Center
    Inventors: Jwa Min Nam, Young Kwang Lee, Sungi Kim, Keunsuk Kim
  • Patent number: 10509031
    Abstract: A method for providing quality control on a lateral flow assay device or for triggering a process-related step, the device including a substrate having at least one sample receiving area, at least one reagent zone downstream and in fluid communication with the at least one sample receiving area, at least one detection zone downstream and in fluid communication with the at least one reagent zone and at least one wicking zone downstream of the at least one detection zone, each fluidly interconnected therewith along at least one fluid flow path. The detection material provided in the at least one reagent zone produces a detectable signal that can be tracked and monitored prior to the completion of at least one test being performed on the lateral flow assay device.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: December 17, 2019
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Zhong Ding, James E. Robinson, David A. Tomasso, David A. Heavner
  • Patent number: 10495644
    Abstract: The disclosure provides for compositions and methods of making and using a foam composition and its utility in clinical applications.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: December 3, 2019
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Jr-Ming Lai, Jen-Chia Wu, Huai-Lu Chen, Hung-Jen Shao
  • Patent number: 10488409
    Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: November 26, 2019
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
  • Patent number: 10481157
    Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 19, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Axel Scherer, Samuel Njoroge, Jingqing Huang
  • Patent number: 10473589
    Abstract: A referencing method for an optical biosensor system using a single sensing region is provided. The method involves limiting the ligand immobilized in a single sensing region to only a portion thereof. In one embodiment, this is accomplished by selectively deactivating a portion of the sensing surface to prevent immobilization of ligand to that portion. As a result, a reference response can be recorded in the same sensing region as a molecular interaction response. Thus, the bulk refractive index can be accurately accounted for in measuring the kinetics of a molecular interaction.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: November 12, 2019
    Assignee: Molecular Devices, LLC
    Inventor: John Gerard Quinn
  • Patent number: 10473665
    Abstract: The present invention relates to methods and systems for detecting one or more analytes in a sample and/or for classifying a sample. In particular, the present invention relates to methods and systems which can be used to detect the analytes in real time and which rely on flowing through a microfluidic device one or more types of sensor molecule each comprising a domain that binds one or more analytes, a chemiluminescent donor domain and an acceptor domain, wherein the separation and relative orientation of the chemiluminescent donor domain and the acceptor domain, in the presence and/or the absence of analyte, is within +50% of the Forster distance.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: November 12, 2019
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Stephen Charles Trowell, Helen Dacres, Nam Cao Hoai Le, Murat Gel, Yonggang Zhu, Nan Wu
  • Patent number: 10466237
    Abstract: An object is to provide an immunochromatography detection method and an immunochromatography kit in which a prozone phenomenon occurring in a sandwich method when using an analyte in which an antigen is present in a large excess amount is suppressed/excluded. The object was achieved by retaining a nonionic and hydrophilic surfactant having an HLB value of 13 to 18 in a sample addition part of an immunochromatography device, and also using a membrane having a fast flow speed as a membrane to be used for a chromatograph medium.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: November 5, 2019
    Assignee: TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Keita Suzuki, Hisahiko Iwamoto
  • Patent number: 10466241
    Abstract: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: November 5, 2019
    Assignee: The University of British Columbia
    Inventors: Anupam Singhal, Carl L. G. Hansen, John W. Schrader, Charles A. Haynes, Daniel J. Da Costa
  • Patent number: 10457908
    Abstract: The present invention relates to a method of analysis comprising the preparation and the analysis of a sample in a flexible container without direct handling of the sample and without reopening the flexible container at the end of the preparation of the sample, and also to a container and a kit that enable the implementation of this method.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: October 29, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, PRESTODIAG, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Roberto Calemczuk, David Carrara, Thierry Livache, Thibaut Mercey, Félix Piat, Yoann Roupioz, Sami Slimani
  • Patent number: 10451618
    Abstract: A resonator sensor module is disclosed. The resonator sensor module includes one or more sensing resonators that includes binding sites for an analyte material; one or more reference resonators that lacks any binding sites for the analyte material; a module interface; and one or more switches each including a first position that operatively couples at least one of the one or more sensing resonators and the module interface and a second position that operatively couples at least one of the one or more reference resonators and the module interface.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: October 22, 2019
    Assignee: QORVO US, INC.
    Inventor: John Mark Tischer
  • Patent number: 10451622
    Abstract: A centripetal microfluidic platform comprised of a microfluidics disc and a reader for testing LAL-reactive substances in fluid samples is provided. The microfluidic disc may comprise at least two testing areas wherein each testing area includes a reservoir portion for receiving at least one fluid sample. The disc may comprise a distribution network portion in fluid communication with the reservoir portion. Each distribution network portion may comprise a distribution network of at least four (4) channels, wherein each channel has a metering portion and at least one analysis chamber portion. The analysis chamber portion may comprise a mixing chamber for mixing samples and reagents and an optical chamber portion that is compatible with an optical reader. The metering portion may be sized to meter an aliquot of the fluid sample for analysis in the analysis chamber portion. At least one analysis chamber portion has at least one reagent isolated therein.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 22, 2019
    Assignee: BL TECHNOLOGIES, INC.
    Inventors: Paul Charles Melanson, Richard Douglas Godec, Matthew Kaddeland Stonesmith, Darren Barry Smith, Chao Sun
  • Patent number: 10451617
    Abstract: A method for capturing a molecule in a sample, comprising mixing the sample with magnetic particles. Each of the particles being coupled with an element capable of binding selectively to the molecule for capture, so as to form at least one complex comprising a magnetic particle. The element and the molecule bound to the element, immobilizing the at least one complex on a support comprising ordered magnetic field microsources.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 22, 2019
    Assignees: Centre National de la Recherche Scientifique(CNRS), Institut Polytechnique de Grenoble
    Inventors: Guillaume Blair, Luiz Fernando Zanini, Gilbert Reyne, Nora Dempsey, Marianne Weidenhaupt, Franz Bruckert, Orphée Cugat
  • Patent number: 10434511
    Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from 30 ?L plasma samples within approximately 100 minutes with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyses of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed, as a non-invasive alternative to the conventional biopsy and immunohistochemistry.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 8, 2019
    Assignee: University of Kansas
    Inventors: Mei He, Yong Zeng, Andrew Godwin
  • Patent number: 10429380
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: October 1, 2019
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 10429383
    Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 1, 2019
    Assignee: Abaxis, Inc.
    Inventors: Rajesh Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz