Abstract: Disclosed is a nucleic acid molecule from nematodes encoding for phosphoglycerate mutase (PGM) polypeptides. The PGM-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of PGM-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production. Such inhibitors are useful for control nematode infection.
Type:
Grant
Filed:
February 26, 2002
Date of Patent:
November 16, 2004
Assignee:
Divergence, Inc.
Inventors:
Andrew P. Kloek, Deryck Jeremy Williams, Brandy Salmon, John D. Bradley