Patents Examined by Rebecca M Fritchman
  • Patent number: 11150236
    Abstract: In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in a corresponding well. The quality may include, for example, surface coupled mass, density, viscosity, and/or viscoelasticity of the living biological cells. The system also includes logic for measuring a resonant frequency and motional resistance associated with each sensor device and logic for processing the measured resonant frequency and motional resistance. Moreover, the system includes logic for displaying one or more graphs showing one or more characteristics of the living biological cells contained in the wells.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 19, 2021
    Assignee: University of Massachusetts
    Inventors: Abiche H. Dewilde, Berk Akinci, Joel M. Therrien, Kenneth A. Marx, Susan J. Braunhut
  • Patent number: 11143655
    Abstract: Methods for obtaining a sample from a subject include providing a sample collection room within a retail store; and obtaining a sample from a subject at a retail location. Sample collection rooms may house a sample analysis device or system. Samples may be small, e.g., a finger-stick capillary blood sample.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 12, 2021
    Assignee: Labrador Diagnostics LLC
    Inventors: Daniel Young, Chinmay Pangarkar
  • Patent number: 11142790
    Abstract: There is provided a microfluidic device comprising: a plurality of wells, each well comprising one opening to function as an inlet and an outlet for the well, wherein each opening is in fluid communication with a common fluidic channel, and wherein each opening is connected to the common fluidic channel via an isolation channel, and wherein the plurality of wells is arranged on the device in a radially symmetrical pattern. There is also provided a system and method comprising the device.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: October 12, 2021
    Inventors: Jackie Y. Ying, Guolin Xu, Rensheng Deng
  • Patent number: 11137410
    Abstract: Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: October 5, 2021
    Assignees: Quest Diagnostics Investments LLC, Los Angeles Biomedical Research Institute
    Inventors: Kamyar Kalantar-Zedeh, Michael P. Caulfield, Wael A. Salameh
  • Patent number: 11137409
    Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: October 5, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Hunter B. Moore, Eduardo Gonzalez Barreda, Ernest E. Moore
  • Patent number: 11118214
    Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: September 14, 2021
    Inventors: Steen Hauge Matthiesen, Kenneth H. Petersen, Tim Svenstrup Poulsen, Charles M. Hansen
  • Patent number: 11105819
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: August 31, 2021
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Patent number: 11091790
    Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: August 17, 2021
    Inventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
  • Patent number: 11060978
    Abstract: Methods are provided for deriving/determining an analyte concentration that include recording measurement values during a time development indicating a progress of a detection reaction of at least one test substance and a body fluid sample and providing at least one measurement curve F(t) containing the measurement values, where the detection reaction is known to be influenced by the analyte concentration and at least one disturbance variable Y. The methods also include deriving an end value of the measurement curve to form a first variable x1, and deriving at least one fit parameter by taking into account an exponential characteristic of the measurement curve, and where the fit parameter forms at least one second variable x2. The methods further include deriving/determining the analyte concentration by using at least one multivariate evaluation algorithm adapted to combine x1 and x2. Also provided are computer programs and devices that incorporate the same.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 13, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Christian Ringemann, Markus Plum, Wolfgang Petrich, Timo Ottenstein
  • Patent number: 11053535
    Abstract: Devices, such as chips for DNA analysis, have at least one fluid transport nanochannel with at least one intersecting (e.g., transverse) sensing nanochannel that can be monitored for change in ionic current to determine characteristics or parameters of interest, e.g., molecular identification, length determination, localized (probe) mapping and the like.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: July 6, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Michael Ramsey, Jean Pierre Alarie, Laurent Menard
  • Patent number: 11035799
    Abstract: A method for calibrating an imager of a reagent analyzer, comprises positioning a dry reagent pad at a first read position in a field of view of the imager, the first read position illuminated by an illumination source with a first intensity, detecting a reference optical signal by the imager, indicative of a first reflectance value of the dry reagent pad at the first read position, positioning the dry reagent pad at a second read position, the second read position illuminated with a second intensity different from the first intensity, detecting a first optical signal by the imager, indicative of a second reflectance value of the dry reagent pad at the second read position, and calculating, by a processor, a calibration factor for the dry reagent pad at the second read position based on a difference between the reference optical signal and the first optical signal.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: June 15, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Chris Thomas Zimmerle, Amy Zercher, Jennifer Ann Goldsburg
  • Patent number: 11017899
    Abstract: A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to determine, in response to a port receiving a test strip, whether an auto-send feature is enabled on the handheld medical device, determine whether the handheld medical device is paired with a mobile computing device, and selectively instruct a wireless transceiver to establish a wireless connection and communicate a glucose measurement and identifying information to the mobile computing device. The mobile computing device is configured to execute the diabetes management application. The diabetes management application is configured to process a plurality of glucose measurements and identifying information associated with each of a plurality of glucose measurements.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: May 25, 2021
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Eric S. Carlsgaard, David B. Markisohn, Mark Mears
  • Patent number: 11008611
    Abstract: Devices that include a substrate; a source region and a drain region formed within the substrate and having a channel region provided therebetween; a first insulating layer formed over the channel region; a first floating gate formed over the first insulating layer, the first floating gate configured to respond to an analyte in a target material; and a second gate formed over the first floating gate, the second gate capacatively coupled but not electrically connected to the first floating gate.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: May 18, 2021
    Assignee: UNM Rainforest Innovations
    Inventors: Payman Zarkesh-Ha, Steven R. J. Brueck, Jeremy Edwards
  • Patent number: 10983112
    Abstract: Methods for identification and quantification of bile acids are disclosed. Bile acids in plasma, serum and/or blood such as a dried blood spot are used to identify subjects with a Niemann-Pick disease. The methods include measuring levels of a bile acid, such as 3?,5?,6?-trihydroxycholanic acid, N-(3?,5?,6?-trihydroxy-cholan-24-oyl)glycine, N-(3?,5?,6?-trihydroxy-cholan-24-oyl)taurine, or a combination thereof. Detection of bile acids involve mass spectroscopy and/or a combination of mass spectroscopy and liquid chromatography such as a LC-MS/MS assay. The methods can be used with sphingomyelinase assays to detect, diagnose and differentiate between Niemann-Pick A/B and Niemann-Pick C (NPC) disease.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: April 20, 2021
    Assignee: Washington University
    Inventors: Daniel Ory, Xuntian Jiang
  • Patent number: 10981163
    Abstract: This disclosure concerns a method of providing a hydrophobic coating on a microfluidic chip that promotes the discrete flow of at least one liquid. It includes applying the hydrophobic coating onto an area of the microfluidic chip. The disclosure further includes a microfluidic chip that provides discrete flow of at least one liquid.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: April 20, 2021
    Assignee: ABS GLOBAL, INC.
    Inventors: John Larsen, Yu Zhou, Zheng Xia
  • Patent number: 10973968
    Abstract: A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 13, 2021
    Inventor: Justin B. Rohde
  • Patent number: 10962508
    Abstract: Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: March 30, 2021
    Assignee: University of Virginia Patent Foundation
    Inventors: William F. Walker, Francesco Viola, F. William Mauldin, II
  • Patent number: 10955424
    Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 23, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel Clarke
  • Patent number: 10928366
    Abstract: A composition, method and device for the preparation of biological samples for subsequent LC-MS analysis using a combined and concurrent protein precipitation and solid phase extraction (SPE) process is described. Through an integrated combination of protein precipitation, filtration, and SPE using a novel zirconia-coated chromatographic media, interfering compounds, such as proteins and phosphate-containing compounds, are eliminated from the biological samples, affording a higher degree of analyte response during LC-MS analysis.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: February 23, 2021
    Assignee: Sigma-Aldrich Co. LLC
    Inventors: Craig Aurand, Charles Mi, Paul Ross, An Trinh, Hillel Brandes, Michael Ye
  • Patent number: 10914719
    Abstract: A significantly improved version of the ASTM D942 Test Method, with apparatus employable to effect the same, is provided. This is useful in measurement of grease oxidation.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: February 9, 2021
    Assignee: TANNAS COMPANY
    Inventors: Theodore W. Selby, Jonathan C. Evans, Gregory C. Miiller, Calvin David Hugo, Sarah Nuss-Warren, Douglas J. Wirsing