Patents Examined by Rebecca M Fritchman
  • Patent number: 11484883
    Abstract: The present invention may provide a microfluidic device including a rotatable body; a first chamber positioned in a direction of an inner wall of the body; a second chamber positioned in a direction of an outer wall of the body from the first chamber; and a backflow prevention unit, and wherein a fluid is transferred from the first chamber to the second chamber, and wherein the backflow prevention unit prevents a backflow of the fluid from the second chamber to the first chamber.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: November 1, 2022
    Inventors: Yoon Kyoung Cho, Tae-Hyeong Kim, Kyusang Lee, Heechul Park
  • Patent number: 11443851
    Abstract: In order to determine, in a cancer test using nematodes, whether or not the nematodes used in the cancer test are adequate, the present invention is characterized in that after a plate on which a urine from a subject and the nematode are set is placed, a cancer test apparatus performs imaging for quality assay of the nematode during the initial two minutes; an analysis apparatus determines a quality of the nematode using the imaging result; after taxis of the nematode is completed, the cancer test apparatus performs imaging for cancer test assay by the nematode; and the analysis apparatus determines the presence or absence of a cancer in the subject using the imaging result.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: September 13, 2022
    Inventors: Minoru Sakairi, Masakazu Sugaya, Koichi Terada, Taku Nakamura, Norihito Kuno
  • Patent number: 11422121
    Abstract: Disclosed are devices and methods for dissolving sample substances such as drug molecules. Also disclosed is use of the method for device for testing dissolution rates of the sample substances. It utilizes lyophilic matrices that create conditions for discriminating the dissolved sample substance from undissolved sample substances. This is aimed at preventing dispersion of the undissolved sample substance to avoid any substantial membrane effects.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: August 23, 2022
    Inventors: Jenni Pessi, Sami Svanbäck, Ilkka Lassila, Jouko Yliruusi
  • Patent number: 11419532
    Abstract: Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: August 23, 2022
    Assignee: Intuity Medical, Inc.
    Inventors: Jeffrey L. Emery, Carole R. Stivers
  • Patent number: 11406984
    Abstract: A transport structure for accommodating a plurality of vials for pharmaceutical, medical or cosmetic use under non-sterile conditions is formed by an accommodation member and by a bearing member releasably connected thereto. The accommodation member comprises a plurality of frustro-conical receptacles in a regular arrangement so that the vials can be accommodated upright and while preventing a direct contact between adjacent vials in the receptacles of the accommodation member. The transport structure comprises latching structures for releasable latching of the accommodation member with the bearing member.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: August 9, 2022
    Inventors: Levent Kusogullari, Marco Apolloni, Gregor Fritz Deutschle
  • Patent number: 11408901
    Abstract: The present invention relates to a strip for measuring blood lipids. The strip for measuring blood lipids, of the present invention, presses, with an optimal pressure or to an optimal height, a contact surface of a protruding part of a measurement layer disposed between an upper cover and a lower substrate, so as to improve the uniform diffusion of a biological sample, thereby having an effect of increasing measurement result accuracy of the biological sample.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 9, 2022
    Inventors: Kyung Hwan Hyun, Jung Hyun Lee, Gi Wook Kim
  • Patent number: 11406980
    Abstract: The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single reaction flow channel with each reaction circuit connected by a bridge flow channel. Alternatively, each reaction circuit may comprise two or more reaction flow channels connected by two or more bridge flow channels. The combination of any two bridge flow channels and a portion of the two or more reaction flow channels between the any two bridge flow channels defining may define the reaction circuit. The reaction module may be arranged as nodes connected by bridge flow channels or each reaction module may be arranged in a parallel fashion on the microfluidic device.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: August 9, 2022
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Paul Blainey, Son Hoang, Huaibin (Eli) Zhang, Jillian Nolan, Soohong Kim
  • Patent number: 11400192
    Abstract: A peritoneal dialysis system is disclosed. An example peritoneal dialysis system includes a water treatment device including a water treatment processor and a first memory and a peritoneal dialysis (“PD”) machine including a PD processor and a second memory. The PD machine is configured to mix water treated by the water treatment device with at least one concentrate to produce a peritoneal dialysis fluid for treatment. The example peritoneal dialysis system also includes a data link between the water treatment processor and the PD processor. The water treatment device is configured to prepare an amount of treated water and, upon communication between the water treatment processor and PD processor over the data link, deliver the amount of the treated water to the PD machine for use in mixing the peritoneal dialysis fluid for the treatment. The treated water has a purity corresponding to an injectable quality or a sterile quality.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: August 2, 2022
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Justin B. Rohde
  • Patent number: 11397185
    Abstract: Provided is a method for analyzing a protein-containing sample. The method comprises (1) dissolving a probe capable of non-specifically interacting with a plurality of proteins in a plurality of solvents having different ionic strengths and/or pH levels; (2) adding a protein-containing sample to a plurality of probe solutions prepared in the step (1), thereby the proteins in the sample and the probe are interacted non-specifically; (3) measuring the fluorescence intensities of the plurality of probe solutions to which the protein-containing sample was added in the step (2); and (4) comparing the pattern of fluorescence intensities obtained in the step (3) with the pattern of fluorescence intensities obtained from a reference sample.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: July 26, 2022
    Inventors: Shunsuke Tomita, Sayaka Ishihara, Ryoji Kurita
  • Patent number: 11279783
    Abstract: The present teaching relates to photo-responsive hydrogels comprising a copolymer comprising N-isopropylacrylamide (NIPAM), a polymerisable derivative of benzospiropyran, a cross-linking agent and an acid, the acid having a pKa of less than 6, wherein the hydrogel is operably responsive to exposure to water so as to undergo spontaneous protonation and swelling. The photo-responsive hydrogels described can be used in the field of microfluidic platforms.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: March 22, 2022
    Inventors: Bartosz Ziolkowski, Larisa Elena Florea, Dermot Diamond
  • Patent number: 11278897
    Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: March 22, 2022
    Inventors: Davide Cucchi, Marco Angelo Bianchessi, Alessandro Cocci, Lillo Raia, Lorenzo Bruno, Nadia Serina, Marco Cereda, Danilo Pirola, Pietro Ferrari, Francesco Ferrara, Alessandro Paolo Bramanti
  • Patent number: 11275072
    Abstract: Effects of Oxygen on grease or another organic paste product can be evaluated with a modified version of the ASTM D942 test methodology for oxidation stability of lubricating greases or other organic paste products by employment of an oxidation pressure vessel, in which at least one of (A) a very small sample of the grease or other organic paste product is deployed for testing within the oxidation pressure vessel such that the sample has an enhanced surface area to mass ratio, and (B) a temperature other than about 99° C. is employed during the testing. In general, the testing is carried out under oxidation pressure conditions. The sample may be evaluated with respect to Oxygen uptake. Additional technique(s) directed to oxidation and/or other properties of the sample may be carried out before to after any Oxygen uptake evaluation, for example, FTIR analysis and/or ATR-FTIR analysis.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 15, 2022
    Assignee: TANNAS COMPANY
    Inventors: Jonathan C. Evans, Theodore W. Selby, Marta Manning
  • Patent number: 11255794
    Abstract: Disclosed are systems and methods for the robust passive detection of airborne toxins using a colorimetric sensor coating onto a optically transparent substrate. In certain embodiments, the substrate is affixed to an adhesive material (tape). In certain embodiments, the sensor and substrate are transparent. In various embodiments, multiple sensors are coated onto selected substrate for the simultaneous detection of multiple toxins. In various embodiments, the sensed or detected toxins include a number of chemical warfare agents and toxic industrial chemicals. In various implementations, the tape is affixed to a remote surface, which may be visually monitored by a camera directly by focusing the camera on the tape or may be affixed to a camera lens by an adhesive backing, such that colorimetric sensor changes may be observed through the lens itself.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 22, 2022
    Assignees: Intelligent Optical Systems, Inc., United States of America as Represented by the Secretary of the Army
    Inventors: Manal Beshay, Janet L. Jensen, James M. Cress
  • Patent number: 11249069
    Abstract: A cancer analysis system includes, so as to perform an efficient image analysis in a cancer screening test using nematodes: a light source unit that irradiates a plate on which nematodes and a urine sample are plotted, from below; a photographing unit that takes an image of the plate irradiated by the light source unit; and an analyzer that analyzes the image taken by the photographing unit. The analyzer: couples a prescribed number of pixels in the image into a larger number of pixels thereof; and performs a chemotaxis assay of the nematodes based on a time variation of information on a luminous center of gravity of the image.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 15, 2022
    Inventors: Minoru Sakairi, Masakazu Sugaya, Koichi Terada, Taku Nakamura, Norihito Kuno
  • Patent number: 11214821
    Abstract: Reagents and methods for using automated laboratory equipment to determine whether the specific gravity of a urine sample is out of normal range as an indication of adulteration. The sodium (Na+) and potassium (K+) normally found in a urine sample can be used as markers. A sodium-potassium dependent ?-galactosidase can be utilized with o-nitrophenylgalactoside (o-NPG) which is cleaved into o-nitrophenol, which turns the sample yellow. The sample can be analyzed by spectrophotometry methods utilized in most clinical analyzers at a pre-determined primary wavelength to obtain a Specific gravity Index (SGI). Measurements of the SGI that are outside a known normal range can indicate that the sample integrity has been compromised.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: January 4, 2022
    Inventor: Jerry W. Denney
  • Patent number: 11215607
    Abstract: To provide a biomarker which is a metabolite included in a biological sample, and which can be collected in a noninvasive method and detected in a convenient analysis method, and which varies according to progression of pathological conditions of irritable bowel syndrome (IBS). Furthermore, such biomarkers are useful for determination of the presence or absence of morbidity of IBS, determination of severity of IBS, determination of types of IBS, determination of necessity of treatment of IBS, and confirmation of drug efficacy of an IBS therapeutic agent.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: January 4, 2022
    Inventors: Shin Fukudo, Seishi Katsumata, Hideaki Tada, Akio Hayashi, Chie Murata
  • Patent number: 11193928
    Abstract: An unmanned vehicle operated autonomously or by remotely piloting incorporates an onboard camera which is affixed with clear tape coated with a chemical colorimetric sensor dye sensitive to chemical warfare agents. Chemical warfare agents are detected by visual review or autonomous measurement of sensor color changes while the unmanned vehicle travels through a region suspected of having chemical warfare agents present. In various implementations, the sensor output color changes may be visually monitored by a vehicle operator viewing the camera image from a remote location. In various embodiments, the detection of chemical warfare agents may be confirmed by processing the coated tape with a calibrated opto-electronic reader.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: December 7, 2021
    Assignee: Intelligent Optical Systems, Inc.
    Inventors: Manal Beshay, Janet L Jensen, James M Cress
  • Patent number: 11187709
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: November 30, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Sascha Antoni, Christian Vogl
  • Patent number: 11187713
    Abstract: A laboratory module for storing and providing access to a plurality of samples, the laboratory module comprising a plurality of bays comprising a plurality of guiding rails and a plurality of rack tray bays for accommodating a plurality of rack trays, and a transport chamber for transporting at least one sample rack to a storage location and for delivering at least one sample rack at predetermined times to a processing system. The transport chamber is adapted to align with any one of the plurality of guiding rails, comprised in the bays and in the rack trays, for placing and moving on the guiding rails the at least one sample rack, and a sensor for sensing the presence and location of a sample rack on any one of the guiding rails, and a barcode scanner that identifies the sample rack and a storage device for storing data.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: November 30, 2021
    Assignee: STRATEC SE
    Inventors: Stephan Habrich, Martin Trump
  • Patent number: 11150236
    Abstract: In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in a corresponding well. The quality may include, for example, surface coupled mass, density, viscosity, and/or viscoelasticity of the living biological cells. The system also includes logic for measuring a resonant frequency and motional resistance associated with each sensor device and logic for processing the measured resonant frequency and motional resistance. Moreover, the system includes logic for displaying one or more graphs showing one or more characteristics of the living biological cells contained in the wells.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 19, 2021
    Assignee: University of Massachusetts
    Inventors: Abiche H. Dewilde, Berk Akinci, Joel M. Therrien, Kenneth A. Marx, Susan J. Braunhut