Patents Examined by Rebecca M Fritchman
  • Patent number: 10725047
    Abstract: A method of analyzing a blood sample is provided. The method comprises providing a glucometer configured to analyze a blood sample and a remote computing device separate from the glucometer, analyzing, by the glucometer, the blood sample, and presenting, by the glucometer, encoded results. The encoded results may be presented as a machine-readable visually-encoded representation of one or more results of the analysis, in which case the method further comprises imaging, by the remote computing device, the representation. The encoded results may be presented as a capacitive profile, in which case the method further comprises reading, by a capacitive sensing input mechanism of the remote computing device, the capacitive profile. According to either option, the method further comprises decoding, by the remote computing device, the representation, thereby retrieving at least one of the results.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: July 28, 2020
    Assignee: GLUCOME, LTD.
    Inventors: Dov Moran, Yiftah Ben Aharon, Itay Cohen, Roee Tuval
  • Patent number: 10717086
    Abstract: A system for isolating and emulsifying particles or cells within droplets includes a microfluidic trapping device having an inlet and an outlet and one or more channels disposed between the inlet and the outlet, at least some of the one or more channels having a plurality of expansion regions serially arranged along the length thereof. A droplet generation device is fluidically coupled to the outlet of the microfluidic trapping device, the droplet generation device has a plurality of channels of a first height that terminate at an interface into a chamber having a second height that is greater than the first height, wherein the plurality of channels droplet generation device and the chamber contain an oil phase therein and wherein the interface is a step junction. In some embodiments, the droplet generation device is itself oriented at an angle with respect to horizontal to prevent droplet coalescence.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 21, 2020
    Assignee: The Regents of the University of California
    Inventors: Dino Di Carlo, Manjima Dhar
  • Patent number: 10641781
    Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: May 5, 2020
    Inventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
  • Patent number: 10613098
    Abstract: The invention relates to a material, process and method for the selective analysis of small molecules. Particularly the invention provides a material and a technique for the analysis of small molecules excluding other large molecular weight (MW) analytes. The process involves selective detection of low molecular weight molecules from a sample comprising the steps of placing said sample with SBA-15 particles; and subjecting the same to desorption ionization mass spectrometry, wherein low molecular weight molecules are selectively detected over the higher molecular weight molecules. A kit for the selective analysis of small molecules is also provided.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: April 7, 2020
    Assignees: Council of Scientific and Industrial Research, Jawaharlal Nehru University
    Inventors: Dipankar Ghosh, Venkateswarlu Panchagnula, Deepika Dhaware
  • Patent number: 10605753
    Abstract: The aim of the invention is to provide a commercially usable and inexpensive device and method with which a sorption enthalpy can be measured in a simple manner. This is achieved by a device for calorimetrically measuring sorption processes, comprising a sorption cell for receiving a sample, the sorption cell having a volume for filling with a sorption gas, and comprising a reference cell likewise for filing with the sorption gas. A measurement gas volume is arranged around the sorption cell for receiving a reference gas, and the reference cell is surrounded by a reference gas volume, which is likewise provided for receiving the reference gas. A gas connection is provided between the sorption cell and the reference cell in order to conduct sorption gas into the sorption cell and the reference cell such that a sorption reaction occurs with the sample in the sorption cell.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: March 31, 2020
    Assignee: WATERS GMBH
    Inventors: Dieter Bathen, Tatjana Hayn, Cornelia Will, Frieder Dreisbach
  • Patent number: 10591428
    Abstract: The present invention relates to a sensor for detecting the presence of a botulinum neurotoxin in a sample, the sensor comprising: (a) an electrically conductive substrate coated with at least one SNAP-25, VAMP or syntaxin protein; and (b) a detection arrangement adapted to enable the detection of the cleavage of at least one SNAP-25, VAMP or syntaxin protein by the botulinum neurotoxin. The invention also relates to methods of making a sensor, methods of detecting and a detection kit for botulinum neurotoxin.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: March 17, 2020
    Inventors: Chris David Gwenin, Jennifer Helen Halliwell
  • Patent number: 10564074
    Abstract: Rose Bengal for detecting a presence of chemical warfare agents. A method of detecting presence of a chemical warfare agent and includes applying a quinoid form of Rose Bengal to a substrate. When the substrate is exposed to the chemical warfare agent, a lactone form of Rose Bengal is spectrally observed because presence of the chemical warfare agent converts the quinoid form to the lactone form of Rose Bengal.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: February 18, 2020
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Jeffery Ray Owens, Rashelle S. McDonald, Dmytro Volkov
  • Patent number: 10539497
    Abstract: A method and a flow cytometer system in which a light path is aligned to optimally direct light from a light source to a flow cell of a flow cytometer instrument are provided. The flow cytometer may include an orientable mirror disposed in the light path between the light source and the flow cell. By changing an orientation of the mirror through a sequence of different orientations, an optimal orientation of the mirror may be determined, and the mirror may be oriented accordingly before proceeding to conduct a flow cytometry investigation.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: January 21, 2020
    Assignee: Essen Instruments, Inc.
    Inventors: Andrew W. Smolak, Erica Dawson Tenent, Kathy L. Rowlen, Garrett S. Wilson, Christopher H. Converse, Evan M. Toth
  • Patent number: 10473675
    Abstract: Described herein are methods for determining the overall survival of maintenance hemodialysis patients. The methods include measuring low density lipoprotein (LDL) particle size and subfraction concentrations as prognostic tools for early mortality risk detection. For example, the presence of increased very small LDL concentration or decreased LDL particle size in blood-serum serves as a useful means for prognostic risk assessment and monitoring.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 12, 2019
    Assignees: Quest Diagnostics Investments Incorporated, Los Angeles Biomedical Research Institute
    Inventors: Kamyar Kalantar-Zadeh, Michael P. Caulfield, Wael A. Salameh
  • Patent number: 10451639
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: October 22, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Sascha Antoni, Christian Vogl
  • Patent number: 10449494
    Abstract: Method for determining a true amount of active product entering a catalytic device of a vehicle exhaust line includes: introducing, into the exhaust gas stream upstream of the device, an active flow rate of active product so that the contaminant and active product are absent at the measurement probe at the outlet of the device, increasing the active flow rate until the second probe measures a given escape content of the product, stabilizing the escape of product, via the measurement provided by the probe, at the given escape content, introducing a theoretical additional test flow rate of product into the exhaust gas stream upstream of the device, waiting until the total content of product measured in response at the second probe has stabilized, and measuring this stabilized total content, and determining the stabilized true additional test flow rate of active product entering the device.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: October 22, 2019
    Inventor: Steven Maertens
  • Patent number: 10434492
    Abstract: A composition, method and device for the preparation of biological samples for subsequent instrumental analyses, such as GC, GC-MS, LC and LC-MS analysis, using a solid phase extraction (SPE) process is described. Through SPE process alone or an integrated combination of protein precipitation, filtration, and SPE using a hydrophobic zirconia-coated chromatographic media, interfering compounds, such as proteins, glycerides and phosphate-containing compounds, are eliminated from the biological, food, environmental and biotechnology samples, affording an enhanced analyte response during the instrumental analysis.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: October 8, 2019
    Assignee: Sigma-Aldrich Co. LLC
    Inventors: Xiaoning Lu, Olga I. Shimelis, Maochun M. Ye
  • Patent number: 10427162
    Abstract: The present disclosure provides systems, devices and methods associates with processing and analyzing samples for molecular diagnostics. The system may process samples using assay cartridges including sample preparation modules and PCR modules. The system may include thermal cycler modules and optics modules to detect the specific nucleic acid sequences in the samples.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 1, 2019
    Assignee: QuanDx Inc.
    Inventors: Xiaojun Lei, Yuan Yuan, Qian Xu, Paul Fleming, Ronan Hayes, Brian Lewis, Bruce Richardson
  • Patent number: 10377938
    Abstract: The present invention relates to nanoparticle smart tags and the use of nanoparticle smart tags in the detection of analyte. In particular, the present invention relates to nanoparticle smart tags that may be used in subgeologic formations to detect analytes of interest in real-time. One embodiment of the present invention provides a method of providing a drilling fluid having a nanoparticle smart tag; and a base fluid; and introducing the drilling fluid in a subsurface geologic formation that has an analyte.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: August 13, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Diptabhas Sarkar, Charles Landis, Ryan P. Collins
  • Patent number: 10379112
    Abstract: A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: August 13, 2019
    Assignees: Advanced Liquid Logic, Inc., Duke University
    Inventors: Ramakrishna Sista, Vamsee K. Pamula, Michael G. Pollack, Vijay Srinivasan, Allen E. Eckhardt, Richard B. Fair
  • Patent number: 10371631
    Abstract: There is provided an optical analysis technique of detecting light of a light-emitting particle in a sample solution in the scanning molecule counting method using the light measurement with a confocal or multiphoton microscope, for suppressing the scattering in detected results of signals of light of light-emitting particles smaller and achieving the improvement of accuracy. The inventive technique comprises moving the position of a light detection region along a predetermined route for multiple circulation times by changing the optical path of the optical system; detecting light from the light detection region and generating time series light intensity data during the moving of the light detection region and detecting individually a signal indicating light from each light-emitting particle existing in the predetermined route using the time series light intensity data obtained in the circulating movements of the light detection region of multiple times.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: August 6, 2019
    Inventors: Tetsuya Tanabe, Mitsushiro Yamaguchi
  • Patent number: 10352954
    Abstract: A sensing tip including a pipette tip having a cavity which communicates with an external environment of the pipette tip through an aperture located at a distal end of the pipette tip, and an impedance sensor having a sensing area including at least two electrodes located respectively outside and inside the pipette tip, wherein the sensing area is arranged within the aperture.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 16, 2019
    Inventors: David Vincent Bonzon, Georges Henri Muller, Philippe Renaud, Yann Barrandon
  • Patent number: 10352941
    Abstract: Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin becomes covalently attached to the amino-functionalized membrane, wherein said heparin is indirectly attached via a spacer to said amino-functionalized membrane and/or said heparin is attached from a single site in said heparin to a single site on said amino-functionalized membrane or to said spacer. Also disclosed are analyte sensors.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: July 16, 2019
    Inventors: Jeff T. Suri, Eric Patterson
  • Patent number: 10345237
    Abstract: This disclosure relates generally to detecting multiple biomarkers on or within a sample, though more specifically, to detecting individual detection moieties within a plurality of detection moieties.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 9, 2019
    Assignee: RareCyte, Inc.
    Inventor: Jeremy Ryan Cooper
  • Patent number: 10337071
    Abstract: The present invention provides a marker which can be used as an indicator for efficacy prediction of an mTOR related anticancer agent or prognostic prediction, and a novel anticancer agent. The present invention provides a method for efficacy evaluation of a cancer drug, and, specifically, a prediction method for the efficacy of an mTOR-related cancer drug by detecting NRF2 abnormality. In addition, the present invention provides a prognostic prediction method for cancer, and, specifically, a prediction method for the prognosis of cancer by detecting NRF2 abnormality. Furthermore, the present invention provides a novel anticancer agent that targets NRF2.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: July 2, 2019
    Assignees: National Cancer Center, INFOCOM CORPORATION
    Inventors: Tatsuhiro Shibata, Shigeru Saito