Patents Examined by Rebecca M Fritchman
  • Patent number: 10352954
    Abstract: A sensing tip including a pipette tip having a cavity which communicates with an external environment of the pipette tip through an aperture located at a distal end of the pipette tip, and an impedance sensor having a sensing area including at least two electrodes located respectively outside and inside the pipette tip, wherein the sensing area is arranged within the aperture.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 16, 2019
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: David Vincent Bonzon, Georges Henri Muller, Philippe Renaud, Yann Barrandon
  • Patent number: 10352941
    Abstract: Methods of covalently attaching heparin to a membrane comprising plasma treating the membrane to produce an amino-functionalized membrane; and reacting the amino-functionalized membrane with heparin under conditions in which heparin becomes covalently attached to the amino-functionalized membrane, wherein said heparin is indirectly attached via a spacer to said amino-functionalized membrane and/or said heparin is attached from a single site in said heparin to a single site on said amino-functionalized membrane or to said spacer. Also disclosed are analyte sensors.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: July 16, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Jeff T. Suri, Eric Patterson
  • Patent number: 10345237
    Abstract: This disclosure relates generally to detecting multiple biomarkers on or within a sample, though more specifically, to detecting individual detection moieties within a plurality of detection moieties.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 9, 2019
    Assignee: RareCyte, Inc.
    Inventor: Jeremy Ryan Cooper
  • Patent number: 10337071
    Abstract: The present invention provides a marker which can be used as an indicator for efficacy prediction of an mTOR related anticancer agent or prognostic prediction, and a novel anticancer agent. The present invention provides a method for efficacy evaluation of a cancer drug, and, specifically, a prediction method for the efficacy of an mTOR-related cancer drug by detecting NRF2 abnormality. In addition, the present invention provides a prognostic prediction method for cancer, and, specifically, a prediction method for the prognosis of cancer by detecting NRF2 abnormality. Furthermore, the present invention provides a novel anticancer agent that targets NRF2.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: July 2, 2019
    Assignees: National Cancer Center, INFOCOM CORPORATION
    Inventors: Tatsuhiro Shibata, Shigeru Saito
  • Patent number: 10315162
    Abstract: Systems and methods are disclosed for determining or diagnosing a reagent dosing system failure to provide sufficient reagent to an exhaust aftertreatment system that includes an SCR catalyst to satisfy a reagent dosing command.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 11, 2019
    Assignee: Cummins Emission Solutions Inc.
    Inventors: Balbahadur Singh, Clyde W. Xi, Mickey R. McDaniel, Baohua Qi, Paul C. McAvoy
  • Patent number: 10309971
    Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: June 4, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Yanni Zhang, Nigel J. Clarke, Richard E. Reitz
  • Patent number: 10309948
    Abstract: A carbon quantifying cell configured to receive a fluid is provided, including two or more electrodes positioned at least partially in the fluid, and meter electronics configured to place an electrical oxidization, polarization, and/or adsorption program across the two or more electrodes and at least partially oxidize carbon materials in the fluid, apply an AC voltage of a predetermined amplitude across the two or more electrodes, measuring the resulting AC current across the two or more electrodes, wherein a ratio of amplitudes and a phase angle difference provides information for calculating a fluid impedance, receive an electrical response of the fluid to the electrical oxidization, polarization, and/or adsorption program, quantify the carbon materials in the fluid using the electrical response, and detect interfering materials in the fluid using the fluid impedance.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: June 4, 2019
    Assignee: HACH COMPANY
    Inventor: Vishnu Rajasekharan
  • Patent number: 10295465
    Abstract: The invention relates to an in vitro diagnostic method for quantification of a clinical chemistry analyte from a clinical sample wherein the clinical chemistry analyte undergoes a chemical reaction or reactions with a reagent or reagents in one or several steps, or in a reaction sequence, or catalyzes a chemical reaction, or reactions, or a reaction in a reaction sequence of a reagent or reagents, in one or several steps, in a reaction system. The reaction or reactions or reaction sequence result in a change of a measurable property of a compound or compounds of said reaction or reactions or reaction sequence.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: May 21, 2019
    Assignee: Arctic Diagnostics Oy
    Inventors: Erkki Soini, Aloksi Soini, Juhani Soini, Niko Meltola
  • Patent number: 10267815
    Abstract: A device for positioning vessels, with a holder for vessels, comprising a series of receptacles arranged on a circular line, for a circular ring-shaped vessel chain, a central area, arranged within the series of receptacles, and having further receptacles for single vessels containing reagents, and means for aligning, and with a carrier for single vessels, which comprises a holding plate in the form of a circular disc or of a part of a circular disc, which has holes for single vessels at certain positions, and which has at least one further means for aligning the carrier to the means for aligning the holder in a certain position, wherein in this position, the holes are aligned to certain further receptacles, the remaining further receptacles are covered up by the holding plate, and single vessels filled with reaction liquid can be inserted into the holes and into the further receptacles aligned thereto.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 23, 2019
    Assignee: Eppendorf AG
    Inventors: Helmut Knofe, Jens-Peter Kroog, Judith Lucke
  • Patent number: 10247742
    Abstract: Chemical compositions and methods provide labeling, detection and measurement of target substances in exhaled human breath, and can be implemented in connection with a handheld device—much like a Breathalyzer portable breath testing unit for alcohol—to support rapid quantification of levels of cannabinoid compounds, such as tetrahydrocannabinol (THC), of suspected users at the roadside.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 2, 2019
    Assignee: HOUND LABS, INC.
    Inventors: Michael Scott Lynn, Hamilton Roger Tang, Kate L. Bechtel, Peter A. Holst
  • Patent number: 10234466
    Abstract: Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator solution including a tetramethylbenzidine (TMB) solution, the indicator being configured to change color; a collection device configured to collect a test sample from a subject. The kit may also include a hemoglobin physiologic level identifier legend, the legend indicating 1) at least one color of the indicator and 2) a physiologic level and/or range of the hemoglobin and/or disease state associated with the color.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 19, 2019
    Inventors: Wilbur A. Lam, Morgan Byrd, Erika Tyburski, Michael L. McKinnon, Siobhan O'Connor, Nathan A. Hotaling
  • Patent number: 10226208
    Abstract: Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: March 12, 2019
    Assignee: Intuity Medical, Inc.
    Inventors: Jeffrey L. Emery, Carole R. Stivers
  • Patent number: 10222339
    Abstract: The present invention relates to an optical H+-sensor, comprising an H+-indicator material, wherein the H+-indicator material is present between a support material and a H+-permeable layered structure, the layered structure comprising an H+-permeable hydrophilic layer and an H+-permeable cation exchange layer. Further, the invention relates to a method for determining the H+-concentration, e.g. expressed as pH, in a product or sample thereof, the method comprising contacting the product or sample with an optical H+-sensor according to the invention, measuring an optical property of the indicator material, and determining the H+-concentration of the product or sample based on said optical property.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: March 5, 2019
    Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
    Inventors: Jacobus Johannes Frederik van Veen, Cornelis Gerardus Josephus Koopal
  • Patent number: 10190150
    Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: January 29, 2019
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
  • Patent number: 10151759
    Abstract: A method of purifying a glycan and/or a glycoconjugate comprising the steps of: (a) providing a stationary phase that comprises cotton; (b) applying a glycan and/or glycoconjugate-containing sample to the stationary phase; (c) washing the stationary phase with a first solvent; and (d) eluting the glycan and/or glycoconjugate from the stationary phase with a second solvent. A kit for purifying a glycan and/or glycoconjugate, the kit comprising: a stationary phase comprising cotton; and instructions for purifying a glycan and/or glycoconjugate according to the disclosed method.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: December 11, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Manfred Wuhrer, Mahdi Hemayatkar, Maurice Henricus Johannes Selman
  • Patent number: 10119945
    Abstract: The objects of embodiments in the present disclosure are to provide a method capable of recovering two or more amine compounds at the same time from a gas or solution, and also to provide a method capable of analyzing the recovered amines. The amine-recovering method comprises the steps (A) and (B). In the step (A), the gas or solution is brought into contact with a solid adsorbent so that the adsorbent may retain the amines. In the step (B), the amines retained by the adsorbent in the step (A) are eluted out by use of a basic compound-containing organic solvent. The solid adsorbent has a substituent group represented by —SO3M (M is H or an alkali metal).
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: November 6, 2018
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Hiroko Watando, Takashi Kuboki
  • Patent number: 10082514
    Abstract: Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: September 25, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Carlos A. Valdez, Audrey M. Williams
  • Patent number: 10018641
    Abstract: Disclosed is the provision of a method for quantifying HDL3 in a test sample without requiring a laborious operation. The method for quantifying cholesterol in high-density lipoprotein 3 comprises allowing a surfactant(s) which specifically react(s) with a high-density lipoprotein 3 to react with a test sample and quantifying cholesterol, and the surfactant(s) is(are) at least one selected from the group consisting of polyoxyethylene polycyclic phenyl ether and polyoxyethylene styrenated phenyl ether.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: July 10, 2018
    Assignee: DENKA SEIKEN CO., LTD.
    Inventors: Noriyuki Sato, Yuhko Hirao, Yasuki Itoh
  • Patent number: 9983211
    Abstract: The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes fluorescent upon reacting to amine groups located on the protein. Following the labeling step, the proteins within the mixture can be separated and analyzed. In a further embodiment, a tag binding fluorogenic reagent that can bind to a tag on a tagged protein is added to specifically label the protein of interest.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: May 29, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Thomas Diller, Bethany Sutton, George Hanson, Timothy Updyke
  • Patent number: 9921234
    Abstract: Chemical compositions and methods provide labeling, detection and measurement of target substances in exhaled human breath, and can be implemented in connection with a handheld device—much like a Breathalyzer portable breath testing unit for alcohol—to support rapid quantification of levels of cannabinoid compounds, such as tetrahydrocannabinol (THC), of suspected users at the roadside.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: March 20, 2018
    Assignee: HOUND LABS, INC.
    Inventors: Michael Scott Lynn, Hamilton Roger Tang, Kate L. Bechtel, Peter A. Holst