Patents Examined by Rebecca Martinez
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Patent number: 9535035Abstract: Provided are an analysis device and an analysis method. According to the device and the method, a giant magnetoresistance (GMR) sensor unit is formed to be the same as the size of one cancer cell or smaller and magnetic resistance according to the number of magnetic nano particles coupled with the one cancer cell by using the GMR sensor unit, thereby not only diagnosing cancer but also simply and cheaply distinguishing the type of the cancer.Type: GrantFiled: July 23, 2013Date of Patent: January 3, 2017Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Moon Youn Jung, Seungkyoung Yang, Kibong Song
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Patent number: 9535029Abstract: The invention relates to electrode chip (EChip) cartridge devices which are used in hot electron-induced electro-chemiluminescence (HECL) and electroluminescence (EL) methods and instrumentation based on the electrical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations in bioaffinity assays, especially outside of central laboratories, but also in rapid screening tests.Type: GrantFiled: June 10, 2011Date of Patent: January 3, 2017Assignee: LABMASTER OYInventors: Sakari Kulmala, Antti Niskanen, Aija Kulmala, Kari Loikas, Matti Pusa
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Patent number: 9523684Abstract: Microfluidic devices and methods for using the same are provided. Aspects of the present disclosure include microfluidic devices that include a separation medium having functional groups which covalently bond to one or more analytes of interest, e.g., proteins, in a sample upon application of an applied stimulus, e.g., light. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.Type: GrantFiled: July 13, 2015Date of Patent: December 20, 2016Assignee: The Regents of the University of CaliforniaInventors: Amy E. Herr, Alex James Hughes
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Patent number: 9506861Abstract: A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.Type: GrantFiled: October 25, 2013Date of Patent: November 29, 2016Assignee: NATIONAL CHUNG CHENG UNIVERSITYInventors: Shau-Chun Wang, Lai-Kwan Chau, Ting-Chou Chang, Chao-Ching Wu
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Patent number: 9494584Abstract: Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labelled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labelled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.Type: GrantFiled: June 21, 2011Date of Patent: November 15, 2016Assignee: Diagnostics for the Real World, Ltd.Inventors: Helen Lee, Ling Huang, Magda Anastassova Dineva, Hsiang Yun Hu
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Patent number: 9488647Abstract: A method detects magnetic particles (1) bound to a binding surface (111) of a sample chamber (112). The detection is made during and/or immediately after the action of an attractive magnetic field. The attractive magnetic field (B) is preceded by a repulsive magnetic field (B) which removes unbound magnetic particles away from the binding surface (111). Due to the attractive magnetic field (B), bound magnetic particles (1) come closer to the binding surface (111), which increases the signal of surface specific detection techniques like frustrated total internal reflection. The signal can be achieved by an attractive magnetic field that is parallel to the binding surface (111) thus inducing the generation of chains between unbound and bound magnetic particles.Type: GrantFiled: October 31, 2012Date of Patent: November 8, 2016Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Joannes Baptist Adrianus Dionisius Van Zon, Ron Martinus Laurentius Van Lieshout
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Patent number: 9482643Abstract: A method of detecting a target biochemical molecular species or at least one property correlated with the occurrence of the biochemical molecular species in a sample whose main component is water. The method includes: obtaining a sample whose main component is water; providing Functionalized Paramagnetic Particles (FPP) including a paramagnetic core and a moiety configured to interact with the target biochemical molecular species or with molecules collectively reporting on a property of the target biochemical molecular species; contacting the FPP with the sample; exposing the sample to an applied magnetic field; measuring a change in a nuclear relaxation property of the sample; and correlating the change to the presence of the biochemical molecular species in the sample or to at least one property correlated with the occurrence of the biochemical molecular species in the sample.Type: GrantFiled: November 26, 2013Date of Patent: November 1, 2016Assignee: Aspect Imaging Ltd.Inventors: Uri Rapoport, Camila Cavallotti, Simonetta Geninatti Crich
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Patent number: 9475048Abstract: A centrifugal force-based microfluidic device for a multiplexed analysis and an analyzing method using the same are provided. The microfluidic device includes a platform and a microfluidic structure including a plurality of chambers formed within the platform and valves positioned between the chambers. The microfluidic structure includes a sample separation chamber connected to a sample injection hole and a plurality of reaction chambers accommodating two or more types of markers specifically reacting to different types of target materials, separately by type.Type: GrantFiled: January 25, 2012Date of Patent: October 25, 2016Assignee: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)Inventors: Yoon-Kyoung Cho, Ji-Woon Park
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Patent number: 9470678Abstract: A method for providing quality control on a lateral flow assay device or for triggering a process-related step, the device including a substrate having at least one sample receiving area, at least one reagent zone downstream and in fluid communication with the at least one sample receiving area, at least one detection zone downstream and in fluid communication with the at least one reagent zone and at least one wicking zone downstream of the at least one detection zone, each fluidly interconnected therewith along at least one fluid flow path. The detection material provided in the at least one reagent zone produces a detectable signal that can be tracked and monitored prior to the completion of at least one test being performed on the lateral flow assay device.Type: GrantFiled: November 15, 2013Date of Patent: October 18, 2016Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Zhong Ding, James E. Robinson, David A. Tomasso, David A. Heavner
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Patent number: 9463458Abstract: The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platelet samples. In another embodiment, the present invention provides a microfluidic device that selectively captures and analyzes a desired amount of target biological particle.Type: GrantFiled: March 2, 2010Date of Patent: October 11, 2016Assignee: Dignity HealthInventor: Jonathan E. Valla
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Patent number: 9453789Abstract: Provided herein are improved cell sorter systems and methods. Such systems and methods provide a self-stabilizing sorter jet to automate calibration, and address the issue of drift in cell sorting systems. The systems and methods presented make it possible to determine and set the charge delay interval automatically with circuitry in the cell sorter. These circuits can set, monitor, and adjust the time delay continuously, allowing for a completely automatic, autonomous, turn-key, self-stabilizing sorter jet.Type: GrantFiled: October 26, 2015Date of Patent: September 27, 2016Assignee: Becton, Dickinson and CompanyInventor: Ger van den Engh
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Patent number: 9448178Abstract: An immunocapture-based in vitro kinase assay on an integrated polydimethylsiloxane (PDMS) microfluidics platform that can reproducibly measure kinase activity from as few as 3,000 cells is described. For this platform, the standard radiometric 32P-ATP labeled phosphate transfer assay was adopted. Implementation on a microfluidic device required the development of methods for repeated trapping and mixing of solid-phase affinity micro beads. A solid state beta-particle camera imbedded directly below the microfluidic device was used to provide real-time quantitative detection of the signal from this and other microfluidic radio bioassays. The integrated device can measure ABL protein kinase activity from BCR-ABL positive leukemia patient samples, and can measure the small molecule phosphorylation such as phosphorylation of the deoxycytidine analog 18F-FAC by deoxycytidine kinase (dCK) isolated from cell lysates.Type: GrantFiled: March 2, 2013Date of Patent: September 20, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Thomas G. Graeber, Hsian-Rong Tseng, Arion F. Hadjioannou (Chatziioannou), Cong Fang, Yanju Wang, Nam T. Vu
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Patent number: 9442067Abstract: A plasmon sensor includes a first metal layer and a second metal layer having an upper surface facing a lower surface of the first metal layer. The upper surface of the first metal layer is configured to receive an electromagnetic wave. A hollow space is provided between the first and second metal layers, and is configured to be filled with a test sample containing a medium. This plasmon sensor has a small size and a simple structure.Type: GrantFiled: April 20, 2010Date of Patent: September 13, 2016Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Masaya Tamura, Hiroshi Kagata
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Patent number: 9435803Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.Type: GrantFiled: November 21, 2012Date of Patent: September 6, 2016Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Axel Scherer, Samuel Njoroge, Jingqing Huang
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Patent number: 9435805Abstract: The present invention is directed to a method for the ultrasensitive detection of beta hemolytic Streptococcus, a bacterium implicated in strep throat, using a specific protease marker. Also disclosed is a device as well as a biosensor, both of which are useful for the detection of beta hemolytic Streptococcus. The biosensor and the device can be used in conjunction with other reagents as part of a kit for detecting strep throat.Type: GrantFiled: September 22, 2011Date of Patent: September 6, 2016Assignee: Woundchek Laboratories (US), Inc.Inventors: Mitchell C. Sanders, Dale Macy, Andrei Rakitin, Courtney Mankus
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Patent number: 9435787Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.Type: GrantFiled: January 20, 2016Date of Patent: September 6, 2016Assignee: Fluidigm Canada Inc.Inventor: Vladimir Baranov
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Patent number: 9435791Abstract: An imaging agent for detecting analytes in an environment includes functionalized nanodiamonds and functionalized magnetic particles that can selectively interact with an analyte. Each functionalized nanodiamond contains at least one color center configured emit light in response to illumination. At least one property of the light emitted by the color centers is related to the proximity of the functionalized magnetic particles to the color centers. This property can be detected to determine that the functionalized nanodiamonds are proximate to the functionalized magnetic particles, to determine that the functionalized nanodiamonds and the functionalized magnetic particles are interacting with the analyte, or other applications. Devices and methods for detecting properties of the analyte by interacting with the functionalized nanodiamonds and functionalized magnetic particles are also provided.Type: GrantFiled: June 27, 2014Date of Patent: September 6, 2016Assignee: Verily Life Sciences, LLCInventors: Victor Marcel Acosta, Vikram Singh Bajaj, Jason Donald Thompson, Eric Peeters
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Patent number: 9435800Abstract: Described are embodiments of an invention for a sample assembly with an electrical conductor for generating an electromagnetic field to speed up the tagging of target antigens with antiparticles for detection of the antigens by electromagnetic read heads. A sample assembly includes a surface with a first set of antibodies bonded thereon. Target antigens are bonded with the first set of antibodies. A second set of antibodies bonded to nanoparticles are exposed to the sample surface to bond with the target antigens. The electrical conductor generates an electromagnetic field that moves the nanoparticle-labeled antibodies toward the antigens to shorten the time to complete their bonding process.Type: GrantFiled: September 14, 2012Date of Patent: September 6, 2016Assignee: International Business Machines CorporationInventors: Allen K. Bates, Nils Haustein, Stephen L. Schwartz, Anna W. Topol, Daniel J. Winarski
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Patent number: 9434977Abstract: There is provided a lateral flow assay that can provide an indication of Gram negative (GN) or Gram positive (GP) infection (or both) within 30 minutes, and desirably in less than 15 minutes. The immediate result would signal the presence of Gram negative bacteria, Gram positive bacteria, both Gram negative and Gram positive bacteria, or no bacteria detected. The detection level would be above a specific bacterial concentration threshold that is clinically significant infection source (e.g. 10^3 cfu/ml) versus the presence of a colonizing bacteria that is not a part of the active infection.Type: GrantFiled: February 27, 2013Date of Patent: September 6, 2016Assignee: Avent, Inc.Inventors: James M. Takeuchi, Adrienne A. Hershey, Scott M. Teixeira, Stephanie M. Martin, Juan Pablo Aragon, Cindy C. Korir-Morrison, Jonathan Hofmekler
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Patent number: 9435798Abstract: A bio-sensing device suitable for the detection and/or characterization of target bioparticles and corresponding method is described. The bio-sensing technique is based on the impact on the heat transfer resistivity value of bioparticles binding in binding cavities of a structured substrate. By sensing temperatures and determining a heat transfer resistivity value based thereon, a characteristic of the target bioparticles can be derived.Type: GrantFiled: February 28, 2014Date of Patent: September 6, 2016Assignees: IMEC, Universiteit HasseltInventors: Kasper Eersels, Marloes Peeters, Anitha Ethirajan, Bart Van Grinsven, Ward De Ceunick, Patrick Wagner