Patents Examined by Rebecca Prouty
  • Patent number: 9885023
    Abstract: Provided are cytochrome P450 polypeptides, including cytochrome P450 santalene oxidase polypeptides, cytochrome P450 bergamotene oxidase polypeptides and cytochrome P450 reductase polypeptides. Also provided are nucleic acid molecules encoding the cytochrome P450 polypeptides. Cells containing the nucleic acids and/or the polypeptides are provided as are methods for producing terpenes, such as santalols and bergamotols, by culturing the cells.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: February 6, 2018
    Assignees: University of British Columbia, The University of Western Australia
    Inventors: Carl Joerg Bohlmann, Maria Luisa Diaz Chavez, Jessie Moniodis
  • Patent number: 9862986
    Abstract: The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: January 9, 2018
    Assignee: Agency for Science, Technology and Research
    Inventors: Bruno Reversade, Stefan Mundlos
  • Patent number: 9834804
    Abstract: The present invention provides an isolated fungal cell that is capable of producing one or more biomass-degrading enzymes and that exhibits increased or decreased expression or copy number of a polynucleotide encoding a PtaB-like protein. Also provided is a fermentation processes for producing one or more biomass-degrading enzymes comprising a fungal cells exhibiting increased or decreased expression or copy number of a polynucleotide encoding a PtaB-like protein. The biomass-degrading enzymes produced by the isolate fungal cell and fermentation processes of the present invention may be used in a process to produce soluble sugars from biomass.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: December 5, 2017
    Assignee: Iogen Energy Corporation
    Inventors: Philippe J. Dufresne, Adam H. Colville, Barbara Fryzuk, Loreta Gudynaite-Savitch, Christopher M. D. Hindle, Boguslaw Ploch, John J. Tomashek
  • Patent number: 9828617
    Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: November 28, 2017
    Assignees: BASF SE, Evolva SA
    Inventors: Michael Naesby, Christophe Folly, Curt Aimé Friis Nielsen, Anaelle Hatsch, Markus Schwab, Oskar Zelder, Stefan Haefner, Hartwig Schroeder, Birgit Hoff, Andrea Molt, Klaus Ditrich, Michael Breuer, Holger Hartmann, Karsten Koerber
  • Patent number: 9828596
    Abstract: The present invention relates to an acyl-CoA synthetase homolog protein from microorganisms of the genus Mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-CoA synthetase homolog protein gene from, e.g., Mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: November 28, 2017
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventor: Misa Ochiai
  • Patent number: 9822354
    Abstract: The present invention relates to an acyl-CoA synthetase homolog protein from microorganisms of the genus Mortierella, a polynucleotide encoding the protein, and so on. The invention provides polynucleotides comprising an acyl-CoA synthetase homolog protein gene from, e.g., Mortierella alpina, expression vectors comprising these polynucleotides and transformants thereof, a method for producing lipids or fatty acids using the transformants, food products containing the lipids or fatty acids produced by the method, etc.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: November 21, 2017
    Assignee: SUNTORY HOLDINGS LIMITED
    Inventor: Misa Ochiai
  • Patent number: 9816122
    Abstract: The invention relates to a method for producing a glycoconjugate comprising an oligosaccharide part covalently linked to a non-sugar moiety selected from the group consisting of amino acids, peptides, proteins, lipids, longer alkyl groups, polyethylene glycols, ?,?-unsaturated amido group and polyvinyl alcohols, using a genetically modified cell.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: November 14, 2017
    Assignee: Glycom A/S
    Inventors: Pauline Peltier-Pain, Gyula Dekany, Christophe Pain, Pierre Chassagne, Nicolas Fierfort, Dóra Molnàr-Gàbor
  • Patent number: 9765319
    Abstract: The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 19, 2017
    Assignee: BP Corporation North America Inc.
    Inventors: Brian Steer, Walter Callen, Shaun Healey, Geoff Hazlewood, Di Wu, David Blum, Alireza Esteghlalian
  • Patent number: 9765322
    Abstract: The present invention discloses isolated polynucleotide encoding enzymes, derived from the fungus Macrophomina phaseolina (“M. phaseolina”), responsible for degrading pectin, and it comprises and/or consists of nucleotide sequences set forth in SEQ ID Nos. 2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32, 35, 38, 41, 44, 47, 50, 53, 56, 59, 62, 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58 and 61, or the complement of such sequences. The present invention also relates to isolated polypeptide encoded by the polynucleotide sequences set forth in SEQ ID Nos. 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60 and 63; a recombinant gene construct comprising the polynucleotide; a transformant and a transgenic fungus comprising the recombinant gene construct, with or having enhanced production of pectin degrading enzyme.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: September 19, 2017
    Assignee: Bangladesh Jute Research Institute
    Inventors: Maqsudul Alam, Mohammed S. Islam, Mohammed M. Hossen, Mohammed S. Haque, Mohammed M. Alam
  • Patent number: 9752161
    Abstract: The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen by culturing cells under conditions suitable for co-production of isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: September 5, 2017
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Gopal K. Chotani, Joseph C. McAuliffe, Caroline M. Peres, Karl J. Sanford, Derek H. Wells
  • Patent number: 9745556
    Abstract: The present invention provides methods of designing and generating glycerol dehydrogenase (GlyDH) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding GlyDH polypeptide variants having altered function as compared to the parent polypeptide. Host cells comprising polynucleotides encoding GlyDH variants and methods of producing lactic acids are also provided in various aspects of the invention.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: August 29, 2017
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Qingzhao Wang, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
  • Patent number: 9732331
    Abstract: The present invention relates to an isolated synthetic polynucleotide encoding the mature amylase AX856 from Bacillus akibai, using codon modified polynucleotide constructs for the expression of the amylase.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: August 15, 2017
    Assignee: Novozymes A/S
    Inventors: Jens Toenne Andersen, Niels Banke
  • Patent number: 9719122
    Abstract: A plurality of isolated polynucleotide sequences encoding enzymes of the astaxanthin pathway is disclosed. The polynucleotides include: (i) a polynucleotide which encodes Phytoene dehydrogenase (crtI) and a first transcriptional regulatory sequence; (ii) a polynucleotide which encodes Beta-lycopene cyclase (lcy-B) and a second transcriptional regulatory sequence; (iii) a polynucleotide which encodes Beta-carotene ketolase (crtW) and a third transcriptional regulatory sequence; and wherein the first, second and third regulatory sequence are selected such that the expression of the Icy-B and the crtW is greater than a level of expression of the crtI. Methods of generating astaxanthin using the plurality of polynucleotide are also disclosed as well as bacterial cells comprising high levels of astaxanthin.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: August 1, 2017
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ron Milo, Lior Zelcbuch, Niv Antonovsky
  • Patent number: 9719115
    Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: August 1, 2017
    Assignees: Kyoto University, Nitto Pharmaceutical Industries, Ltd.
    Inventors: Jun Ogawa, Shigenobu Kishino, Sakayu Shimizu, Yasunori Yonejima
  • Patent number: 9708376
    Abstract: A recombinant fusion protein comprising the moieties B and CT is provided. B is a non-spidroin moiety which provides the capacity of selective interaction with an organic target. CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein. The fusion protein is not comprising any moiety derived from the repetitive fragment of a spider silk protein.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: July 18, 2017
    Assignee: SPIBER TECHNOLOGIES AB
    Inventor: My Hedhammar
  • Patent number: 9707279
    Abstract: The invention provides an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, for use in a method for treating or preventing a disease or condition mediated by IgE antibodies.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: July 18, 2017
    Assignee: Hansa Medical AB
    Inventors: Mattias Collin, Rolf Lood, Karl Carlstrom, Maria Allhorn, Jonathan Sjogren, Falk Nimmerjahn
  • Patent number: 9701951
    Abstract: The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: July 11, 2017
    Assignee: Novozymes, Inc.
    Inventors: Sarah Teter, Connie Ward, Joel Cherry, Aubrey Jones, Paul Harris, Jung Yi
  • Patent number: 9695426
    Abstract: Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: July 4, 2017
    Assignee: The Regents of the University of California
    Inventors: James C. Liao, Shota Atsumi, Anthony F. Cann
  • Patent number: 9688725
    Abstract: Biosurfactants produced by a strain of Bacillus sp and to uses thereof. A composition comprising the biosurfactants, and a method for producing the biosurfactants. A method for obtaining a biosurfactant, and a device for implementing the method. The production of biopesticides or biosurfactants for the phytosanitary industry, and in the fields of the food, cosmetics, pharmaceutical and oil industries and the environment.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: June 27, 2017
    Assignee: Universite Lille 1—Sciences Et Technologies—USTL
    Inventors: Francois Coutte, Philippe Jacques, Didier Lecouturier, Jean-Sebastien Guez, Pascal Dhulster, Valerie Leclere, Max Bechet
  • Patent number: 9677052
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: June 13, 2017
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres