Patents Examined by Rebecca Pruty
  • Compositions and methods for PACE 4 and 4.1 gene and polypeptides in cells
    Patent number: 5863756
    Abstract: Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mammalian endopeptidases that are specific for dibasic amino acid sites. Therapeutic compositions and methods employing PACE 4 or 4.1 or their inhibitors are also provided.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: January 26, 1999
    Assignee: Chiron Corporation
    Inventors: Philip J. Barr, Michael C. Kiefer
  • The catalytic moiety of the glucose-6-phosphatase system: the gene and protein and related mutations
    Patent number: 5460942
    Abstract: This invention relates to nucleic acid sequences and methods useful for producing recombinant glucose-6-phosphate (G-6-Pase). In addition, the invention relates to specific mutations in the gene encoding human G-6-Pase and methods for detecting the mutations and thus diagnosing the genetic disease that causes glycogen storage disease type 1A.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: October 24, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Janice Y. Chou, Ke-Jian Lei, Leslie L. Shelly