Patents Examined by Regina M. DeBerry
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Patent number: 11608381Abstract: Provided herein are therapeutic methods of treatment using agonist leptin receptor (LEPR) antibodies, antigen-binding fragments thereof, or compositions comprising the LEPR antibodies or antigen-binding fragments thereof. Such therapeutic methods include treatment for conditions related to metabolic dysfunction, including for example, lipodystrophy, adiposity or obesity, reducing body weight, non-alcoholic fatty liver disease, hyperphagia, hyperglycemia, insulin resistance, dyslipidemia, hepatic steatosis, and infertility.Type: GrantFiled: April 5, 2019Date of Patent: March 21, 2023Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Jesper Gromada, Panayiotis Stevis, Judith Altarejos, Andrew J. Murphy
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Patent number: 11564973Abstract: The present invention provides methods and compositions for the use of IL-22 for treating conditions of intestinal injury and inflammatory conditions such as graft vs. host disease. Specifically, IL-22 can be used to increase Intestinal Stem Cell (ISC) recovery and for enhancing immune reconstitution following allogeneic hematopoietic transplantation. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22, including a dimeric form of IL-22, in therapeutic compositions for treating graft vs. host disease, including hepatic, thymic, gastrointestinal, or other graft vs. host disease in hematopoietic stem cell transplant patients and in patients with inflammatory intestinal conditions.Type: GrantFiled: December 23, 2019Date of Patent: January 31, 2023Assignees: MEMORIAL SLOAN-KETTERING CANCER CENTER, EVIVE BIOTECHNOLOGY (SHANGHAI) LTDInventors: Marcel Van Den Brink, Alan Hanash, Caroline Lindemans, Tom Tang
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Patent number: 11560416Abstract: A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.Type: GrantFiled: April 20, 2018Date of Patent: January 24, 2023Assignee: YUHAN CORPORATIONInventors: Byung Hyun Choi, In Hwan Lim, Jun Young Park, Jin Hyoung Lee, Ki Hong Kim, Hae Yong Jo, Jun Hwan Kim, Moo Young Song, Jong Gyun Kim
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Patent number: 11559565Abstract: The described invention provides methods for treating an inflammatory brain disease, disorder or condition and for treating a traumatic brain injury having an inflammatory component in a subject in need thereof using isolated erythropoietin (EPO)-derived oligopeptides.Type: GrantFiled: June 5, 2020Date of Patent: January 24, 2023Assignees: United States Government As Represented By The Department of Veterans Affairs, Rutgers, The State University of New JerseyInventors: Peter C. Dowling, Bo Wang, Rui Rong Yuan, Wei Lu
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Patent number: 11535673Abstract: Aspects of the invention provide methods for harnessing the potential of proteins that occur naturally (e.g., in humans) and that have serious but finite toxicity. Aspects of the invention relate to a quantitative systems-biological and structural approach to design a class Mof chimeric proteins that avoid the toxicity of protein drugs while retaining their desired activities. In particular, chimeric proteins containing a variant form of a natural protein fused to a targeting moiety may be administered to a subject to target a signal (e.g., induction of apoptosis) to particular cells without having a generalized toxic effect.Type: GrantFiled: April 5, 2008Date of Patent: December 27, 2022Assignee: President and Fellows of Harvard CoHegeInventors: Pamela A. Silver, Pablo Gabriel Cironi Lopez, David G. Miguez
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Patent number: 11530247Abstract: This invention provides for a fusion protein between a single chain TNFR2 Selective Agonist protein (scTNFR2 Selective Agonist) and a dimerization domain, such as an IgGFc protein. The single chain TNFR2 Selective Agonist moiety provides a therapeutic activity by selectively activating the TNFR2 form of the TNF-? receptor, thus selectively stimulating Tregs and/or increasing myelin deposition.Type: GrantFiled: June 5, 2018Date of Patent: December 20, 2022Assignee: RELINIA, INC.Inventors: David C Foster, Lutz B Giebel, Leonard G Presta
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Patent number: 11525005Abstract: Provided are an anti-CD40 antibody, an antigen binding fragment thereof, and a medical use thereof. Also provided are a chimeric antibody and a humanized antibody including a CDR region of the anti-CD40 antibody, a pharmaceutical composition including the human anti-CD40 antibody and the antigen binding fragment thereof, and an application thereof as an anti-cancer drug. In particular, provided are a humanized anti-CD40 antibody, and an application thereof in preparation of a drug to treat a CD40-mediated disease or disorder.Type: GrantFiled: May 31, 2018Date of Patent: December 13, 2022Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.Inventors: Shude Yan, Jiahua Jiang, Qiyue Hu, Lianshan Zhang, Guoqing Cao, Xueming Qian, Fei Teng
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Patent number: 11524054Abstract: The present invention relates to a method for treating anemia using a long-acting EPO formulation, and more specifically, a method for treating patients with anemia by confirmation of safe, long-acting, and optimal effective dosage and usage in administering a fusion polypeptide which comprises an EPO and an immunoglobulin hybrid Fc to patients with anemia. The method of administering the fusion polypeptide employs an appropriate dosage and usage which not only shows an excellent long-acting property compared to the existing EPO products but also minimizes cardiovascular side effects that may occur due to a rapid increase in hemoglobin level, which is an effect of anemia treatment.Type: GrantFiled: January 8, 2016Date of Patent: December 13, 2022Assignees: GENEXINE, INC., GREEN CROSS CORPORATIONInventors: Sang-In Yang, Jung-Won Woo, Se Hwan Yang, Young Chul Sung, Doo Hong Park, Min Woo Kim
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Patent number: 11518781Abstract: A process for providing a mono-PEGylated protein composition is provided. The process is particularly suitable for providing mono-PEGylated erythropoietin composition. The process comprises subjecting a mixture comprising non-PEGylated, mono-PEGylated and oligo-PEGylated to a hydrophobic interaction chromatography process.Type: GrantFiled: December 28, 2018Date of Patent: December 6, 2022Assignee: Hoffmann-La Roche Inc.Inventor: Wolfgang Koehnlein
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Patent number: 11471510Abstract: Provided herein are methods for the treatment in a subject of anemia, anemia requiring RBC transfusion, low or intermediate-1-risk myelodysplastic syndromes (MDS), and/or non-proliferative chronic myelomonocytic leukemia (CMML) in any mammals wherein the methods comprise administration of Activin-ActRII signaling inhibitors to a subject in need of the treatment.Type: GrantFiled: December 3, 2015Date of Patent: October 18, 2022Assignees: CELGENE CORPORATION, ACCELERON PHARMA INC.Inventors: Kenneth M. Attie, Christopher Rovaldi, Abderrahmane Laadem
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Patent number: 11452761Abstract: A method for inhibiting renal hypofunction in a non-human animal includes administering cat-derived erythropoietin to the non-human animal. The non-human animal may have renal hypofunction. The non-human animal may have chronic kidney disease and the renal hypofunction may be caused by the chronic kidney disease. The cat-derived erythropoietin may be administered repeatedly at a time interval of 7 to 30 days.Type: GrantFiled: January 4, 2019Date of Patent: September 27, 2022Assignee: KANEKA CORPORATIONInventors: Hirokazu Sakamoto, Hiroetsu Suzuki, Kentaro Katayama, Yuki Tochigi
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Patent number: 11453727Abstract: The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.Type: GrantFiled: July 28, 2020Date of Patent: September 27, 2022Assignee: SANOFIInventors: Ercole Rao, Vincent Mikol, Danxi Li, Jochen Kruip, Matthew Davison
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Patent number: 11434269Abstract: The present invention relates methods of treatment using BMP6 antagonists.Type: GrantFiled: June 13, 2017Date of Patent: September 6, 2022Assignee: Novartis AGInventors: Feng Cong, William Dietrich, Nathalie George, Dong Liu, Asher Schachter, Aditi Soni, Jing Zhou
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Patent number: 11433134Abstract: The present invention relates to stable aqueous protein formulations. In particular, disclosed herein are therapeutic protein formulations suitable for parenteral administration having one or more antioxidants.Type: GrantFiled: June 16, 2014Date of Patent: September 6, 2022Assignee: AMGEN INC.Inventors: Christopher James Sloey, Jason Ko, Tiansheng Li
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Patent number: 11414484Abstract: The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.Type: GrantFiled: October 1, 2020Date of Patent: August 16, 2022Assignee: Janssen Biotech, Inc.Inventors: Ken Boakye, Alfred Del Vecchio, John Kehoe, Eilyn Lacy, Lynne Murray, Mary Ryan, Sandra Santulli-Marotto, John Wheeler, Brian Whitaker, Alexey Teplyakov
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Patent number: 11390665Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.Type: GrantFiled: January 14, 2020Date of Patent: July 19, 2022Assignee: The Scripps Research InstituteInventors: Vaughn Smider, Omar A. Bazirgan, Hongyuan Helen Mao, Peter Schultz, Feng Wang, Yong Zhang
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Patent number: 11332534Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.Type: GrantFiled: July 31, 2019Date of Patent: May 17, 2022Assignee: Cephalon, Inc.Inventors: Doris Shim Siew Chen, Lynn Dorothy Poulton, Adam Clarke, David Jose Simon Laine, Matthew Pollard, Bridget Ann Cooksey, Anthony Doyle, Jason William Gill
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Patent number: 11332520Abstract: The present disclosure relates to antibodies and binding fragments to a Tenascin, in particular the FBG domain of a Tenascin, which are potentially less immunogenic than the parent antibody. The disclosure also relates to compositions comprising the antibody or binding fragment and use of any one of the same for diagnosis, prognosis and/or treatment of disorders such as those associated with chronic inflammation. The disclosure further provides methods of making the antibodies.Type: GrantFiled: February 10, 2017Date of Patent: May 17, 2022Assignee: STERLING IP LIMITEDInventors: Patrick Hextall, Kim Suzanne Midwood, Eric Culbert
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Patent number: 11318158Abstract: A method is provided of decreasing or increasing the activity of a Pappalysin polypeptide by decreasing or increasing the level of interacting Pappalysin and stanniocalcin polypeptides. A method is also provided of preventing, treating or ameliorating a clinical condition in a mammalian subject, such as a human being, said method comprising administering to said mammalian subject, such as human being an effective amount of a stanniocalcin polypeptide. Moreover, a method is provided of preventing, treating or ameliorating a clinical condition in a mammalian subject, such as a human being, said method comprising administering to said mammalian subject, such as human being an effective amount of an agent capable of antagonizing interaction of a stanniocalcin polypeptide with a Pappalysin polypeptide.Type: GrantFiled: October 11, 2019Date of Patent: May 3, 2022Assignee: Aarhus UniversitetInventors: Claus Oxvig, Jakob Hauge Mikkelsen, Malene Runge Jepsen
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Patent number: 11279766Abstract: The present invention provides new anti-SIRPa antibodies able to specifically antagonize the interaction between SIRPa and CD47, without affecting the interaction between SIRPg and CD47, and their uses.Type: GrantFiled: April 14, 2017Date of Patent: March 22, 2022Assignee: OSE IMMUNOTHERAPEUTICSInventors: Nicolas Poirier, Caroline Mary, Bernard Vanhove, Vanessa Gauttier, Virginie Thepenier, Sabrina Pengam