Abstract: Compounds of the formula: ##EQU1## in which R.sup.4 and R.sup. 5 are methyl or R.sup. 4 is hydrogen and R.sup.5 is alkyl of 1 to 5 carbon atoms or phenethyl, or a non-toxic acid addition salt thereof, are claudogenic-interceptive agents useful in preventing or terminating pregnancy in mammals.

Abstract: Novel peptide compounds of the formulaGlu-His-X.sup.3 -X.sup.4 -X.sup.5 -X.sup.6 -X.sup.7 -X.sup.8 -Pro-Ware provided together with their acid addition salts and their complexes with pharmaceutically acceptable metals. The compounds are LH-RH analogues and together with their salts and complexes exhibit LH-RH agonist activity. In the formulaX.sup.3 and X.sup.5 are the same or different and each is phenylalanyl optionally substituted in the benzene ring;X.sup.4 and X.sup.6 are the same or different and each is selected from glycyl, alanyl (D- or L-) and asparaginyl;X.sup.7 is a radical of a neutral hydrophobic nonsulphur containing non-heterocyclic amino acid;X.sup.8 is a radical of a basic amino acid or is glycyl or phenylalanyl optionally substituted in the benzene ring; andW is selected from glycine amide and a group --NR.sup.1 R.sup.2.All references are to the L-amino acids and their radicals except in the case of glycine and unless otherwise stated.

Abstract: Antimicrobial agent particularly effective as an antiviral agent but also exhibiting antifungal and antibacterial activity characterized as a triad containing peptide, fatty acid and carbohydrate moieties.

Abstract: Method of treating excessive fibrinolysis with a modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated by--(R)(R).sub.X W groups,wherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is --OH, --NH.sub.2, --NHC.sub.2 H.sub.5, --OCH.sub.3, or --OC.sub.2 H.sub.5.

Abstract: The growth hormone release inhibiting compound: ##EQU1## the corresponding linear heptadecapeptide, non-toxic acid addition salts and intermediates therefore are herein described, in which Trp is D-tryptophyl or L-tryptophyl and each of the other optically active amino acid moieties are of the L-configuration and A represents --OH, --NH.sub.2, dimethylamino, alkylamino of 1-5 carbon atoms or phenethylamino.

Abstract: Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.

Abstract: Compounds of the formula: ##EQU1## in which m and n are independently one of the integers from 1 to 5, inclusive, and pharmaceutically acceptable salts thereof, inhibit the release of growth hormone and are useful in the treatment of diabetes mellitus and acromegaly.

Abstract: The tetradecapeptide Ala-Gly-Tyr-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Tyr-OH is described as well as novel intermediates used in the synthesis of such tetradecapeptide. This tetradecapeptide inhibits the release of growth hormone.

Abstract: The method of utilizing .alpha.,.beta.-unsaturated amino acids, acyl, and N-acyl derivatives as linking agents in the solid phase synthesis of peptides with the corresponding production of carboxyl terminal amides. Preferred unsaturated amino acids are dehydroalanine and dehydrobutyrine which are constituents in naturally occurring amides such as nisin and subtilin. The synthesis follows conventional lines of R. B. Merrifield et al including blocking of the amino nitrogen, with the exception that the release agent contains an amount of water equimolar to the reactant .alpha.,.beta.-unsaturated amino acid.

Abstract: [6-TYR] Secretin is biologically active and can be radio-iodinated for use in the radioimmunoassay of secretin. The peptide can be produced by solid phase synthesis using benzhydrylamine resin as the support.

Abstract: A process for N-trifluoroacetylating an amino compound, such as an amino acid or a peptide, comprising reacting the amino compound with sym-trichlorotrifluoroacetone in a dimethyl sulfoxide solvent under substantially neutral conditions.

Abstract: A mixed acid anhydride consisting of higher fatty acid having 6 to 22 carbon atoms and sulfuric anhydride is reacted with amino acids, peptides or proteins in the presence of a base to form N-higher aliphatic acyl derivatives of amino acids, peptides or proteins respectively in good yield. The reaction mixture comprises N-acylated-amino acids, peptides or -proteins and sulfate salts and may be directly used as detergent.

Abstract: The present invention is concerned with the production of novel derivatives of thyroid hormones which are useful in the radioimmunoassay (RIA) of such hormones. The invention is particularly concerned with derivatives of thyroxine and triiodothyronine which contain an additional phenol group which is readily iodinatable so that the phenol conjugate can be readily tagged with a radioactive iodine isotope, such as .sup.125 I or .sup.131 I, without detrimentally interfering with the ability of the tagged conjugate so competitively bind with the naturally occurring thyroid hormone in the biological liquid to be analyzed by RIA technique. The invention is also concerned with the iodine-tagged derivatives or conjugates.

Abstract: Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity.

Abstract: The specification describes the total synthesis of L-norleucine-13-motilin ased on the replacement of the L-methionine radical located in the 13-position by an L-norleucine radical. In accordance with the present day development of peptide synthesis the central arginyl-methionyl-bond (amino acids 12 and 13 of motilin) can in practice hardly be synthesised, while on the other hand the norleucine-13-docosapeptide corresponding to motilin can be more readily produced synthetically, and this provides for a comparatively rapid determination of structure and can give important information as regards the biological effect specificity of methionine.

Abstract: Dipeptides of the formula: ##EQU1## wherein n is an integer from 0 to 5, R.sub.1 is an alkyl, alkylaryl or alicyclic radical, and R.sub.2 is a cycloalkenyl radical, and, in addition, may be phenyl when n is 0. The carbon marked with an asterisk is always of the L-configuration. These compounds have a sweet taste and are useful as sweetening agents.

Abstract: A new octapeptide having profound angiotensin antagonist properties has been found. The new compound resembles angiotensin II except for the two terminal amino acids, carrying unnatural amino acids at the N-terminus, and at the C-terminus.

Abstract: Octapeptide derivatives characterized by an oxygen or sulfur-containing moiety in the C-terminal position are potent inhibitors of the pharmacological effects of Angiotensin and possess the additional advantage of a favorable antagonist/agonist ratio.

Abstract: A process for producing new pepstatins having anti-pepsin activity by cultivating a pepstatin producing strain in a nutrient medium containing assimilable carbon sources and nitrogen sources, and extracting the new pepstatins from the cultivated broth or medium.

Abstract: The novel decapeptide amide derivatives of the formula(Pyr)Glu-His-Trp-Ser-R.sub.1 -R.sub.2 -R.sub.3 -Arg-Pro-Gly-NH.sub.2wherein R.sub.1 is Tyr or Phe; R.sub.2 is D-Nle, D-Nva, D-Abu, D-Phe, D-Ser, D-Thr or D-Met and R.sub.3 is Leu, Ile or Nle have a strong ovulation inducing activity.